The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.

scientific article

The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/FEBS.13780
P932PMC publication ID5140733
P698PubMed publication ID27286897

P50authorHao LiQ59749262
Paula Da FonsecaQ73783916
P2093author name stringMatthew Bogyo
P2860cites workSpread of artemisinin resistance in Plasmodium falciparum malariaQ21032481
Inhibitors selective for mycobacterial versus human proteasomesQ27657451
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistanceQ28546636
Proteasome inhibitors block development of Plasmodium spp.Q33700189
Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probesQ34061291
Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasomeQ34282526
2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopyQ34466607
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicityQ34473136
Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6Q35646003
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitorsQ36237082
Structure- and function-based design of Plasmodium-selective proteasome inhibitorsQ36584903
20S proteasome and its inhibitors: crystallographic knowledge for drug developmentQ36742369
Proteasome inhibitors: an expanding army attacking a unique targetQ37979388
Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug developmentQ38019864
Covalent and non-covalent reversible proteasome inhibitionQ38054702
Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targetingQ38088874
Interplay between the virus and the ubiquitin-proteasome system: molecular mechanism of viral pathogenesisQ38596791
Rational Design of Proteasome Inhibitors as Antimalarial DrugsQ41602192
Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.Q41604784
The Resolution RevolutionQ57806883
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
Plasmodium falciparumQ311383
cryogenic electron microscopyQ5190506
P304page(s)4238-4243
P577publication date2016-07-02
P1433published inFEBS JournalQ1388041
P1476titleThe cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria
P478volume283

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cites work (P2860)
Q92563101Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
Q40139788Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
Q36392578High-resolution cryo-EM proteasome structures in drug development.
Q39103077Targeting proteasomes in infectious organisms to combat disease
Q92231044The genomic architecture of antimalarial drug resistance
Q56380854The proteasome as a target to combat malaria: hits and misses
Q56346314Validation of Babesia proteasome as a drug target
Q91153166cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria

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