scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Michal Sharon | Q21264412 |
P2093 | author name string | Gili Ben-Nissan | |
P2860 | cites work | Intrinsically unstructured proteins and their functions | Q22061731 |
Classification of intrinsically disordered regions and proteins | Q22061736 | ||
Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity | Q82066538 | ||
Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form | Q86045061 | ||
Ubiquitin-independent degradation of antiapoptotic MCL-1. | Q39715640 | ||
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activation | Q39760680 | ||
NADH binds and stabilizes the 26S proteasomes independent of ATP. | Q39997925 | ||
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein trafficking | Q40015705 | ||
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells | Q40100471 | ||
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome | Q40115986 | ||
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway | Q40115992 | ||
NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53. | Q40124637 | ||
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation | Q40323831 | ||
The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation | Q40484581 | ||
Association of immunoproteasomes with the endoplasmic reticulum | Q40839103 | ||
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. | Q40902473 | ||
Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state | Q40984011 | ||
Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90. | Q41027019 | ||
Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome | Q41197961 | ||
Cytolocation of prosome antigens on intermediate filament subnetworks of cytokeratin, vimentin and desmin type. | Q41485710 | ||
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon | Q41810892 | ||
T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes | Q41923180 | ||
Redox control of 20S proteasome gating | Q42124117 | ||
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane | Q42235376 | ||
Mechanism of direct degradation of IkappaBalpha by 20S proteasome | Q42482608 | ||
c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics | Q42576383 | ||
The nanny model for IDPs. | Q43258539 | ||
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome | Q43816254 | ||
Increased degradation of oxidized proteins in yeast defective in 26 S proteasome assembly | Q44082373 | ||
Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs. | Q44123714 | ||
Proteasomal degradation of tau protein | Q44163168 | ||
20 S proteasome from Saccharomyces cerevisiae is responsive to redox modifications and is S-glutathionylated | Q44200243 | ||
Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway | Q44251448 | ||
Approval summary for bortezomib for injection in the treatment of multiple myeloma | Q44951957 | ||
Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome | Q45023589 | ||
Heightened levels of circulating 20S proteasome in critically ill patients. | Q46539143 | ||
Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome | Q46627706 | ||
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress | Q24296668 | ||
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome | Q24302180 | ||
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer | Q24305235 | ||
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex | Q24312855 | ||
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b) | Q24317177 | ||
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome | Q24535198 | ||
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome | Q24681597 | ||
Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond | Q26859368 | ||
Immunoproteasomes: structure, function, and antigen presentation | Q27024527 | ||
Applied techniques for mining natural proteasome inhibitors | Q27026146 | ||
Structural basis for the activation of 20S proteasomes by 11S regulators | Q27628418 | ||
Quinone reductase acts as a redox switch of the 20S yeast proteasome | Q27929880 | ||
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle | Q27930959 | ||
Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination | Q27932737 | ||
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis | Q27933881 | ||
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle | Q27938094 | ||
Regulation of CD8+ T cell development by thymus-specific proteasomes | Q28116400 | ||
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis | Q28143710 | ||
Polo-like kinase interacts with proteasomes and regulates their activity | Q28201240 | ||
Interaction of Hsp90 with 20S proteasome: thermodynamic and kinetic characterization | Q28214346 | ||
The role of the proteasome activator PA28 in MHC class I antigen processing | Q28219263 | ||
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration | Q28236609 | ||
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1 | Q28238115 | ||
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia | Q28256645 | ||
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells | Q28279454 | ||
The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review | Q28283466 | ||
Ubiquitin-independent degradation of proteins by the proteasome | Q28284043 | ||
Ubiquitin-independent proteasomal degradation | Q28290917 | ||
Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice | Q28291312 | ||
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression | Q28293759 | ||
The testis-specific proteasome subunit Prosalpha6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis | Q47072730 | ||
Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity | Q48923815 | ||
Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines | Q49102090 | ||
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. | Q50479449 | ||
Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro. | Q52978719 | ||
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. | Q53624251 | ||
Cell cycle-dependent caspase-like activity that cleaves p27KIP1 is the β1 subunit of the 20S proteasome | Q61043686 | ||
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain) | Q68127933 | ||
Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90 | Q71139075 | ||
Age-dependent association of isolated bovine lens multicatalytic proteinase complex (proteasome) with heat-shock protein 90, an endogenous inhibitor | Q71557789 | ||
Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein | Q80086881 | ||
Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiation | Q80379217 | ||
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop | Q28295179 | ||
Proteome half-life dynamics in living human cells | Q28303198 | ||
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73 | Q28305429 | ||
Regulation of proteasome activity in health and disease | Q28392708 | ||
Biological and chemical approaches to diseases of proteostasis deficiency | Q29616633 | ||
Protein degradation and protection against misfolded or damaged proteins | Q29618400 | ||
NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest | Q33627637 | ||
14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer | Q33705055 | ||
MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change | Q33897779 | ||
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination | Q33908311 | ||
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. | Q33962101 | ||
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. | Q34088438 | ||
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase | Q34340947 | ||
Proteasome inhibitors: from research tools to drug candidates | Q34341985 | ||
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded | Q34426417 | ||
The axial channel of the 20S proteasome opens upon binding of the PA200 activator | Q34555139 | ||
Circulating proteasomes after burn injury | Q34665247 | ||
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein | Q34868376 | ||
Oxidative stress-mediated regulation of proteasome complexes | Q34994401 | ||
Intracellular localization of proteasomes | Q35097620 | ||
Regulation of the 26S proteasome complex during oxidative stress | Q35120069 | ||
Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice | Q35187068 | ||
Ubiquitin-independent proteasomal degradation during oncogenic viral infections | Q35354212 | ||
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens | Q35589124 | ||
The 26S proteasome complex: an attractive target for cancer therapy | Q35624079 | ||
MDM2 and prognosis. | Q35646484 | ||
Transformation of the proteasome with age-related macular degeneration | Q35746946 | ||
Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress | Q35880062 | ||
The association of prosomes with some of the intermediate filament networks of the animal cell | Q36219352 | ||
Dynamic association of proteasomal machinery with the centrosome | Q36342153 | ||
NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease | Q36451851 | ||
Subcellular distribution and dynamics of active proteasome complexes unraveled by a workflow combining in vivo complex cross-linking and quantitative proteomics. | Q36666357 | ||
Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons | Q36796902 | ||
Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus | Q36898023 | ||
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. | Q36945044 | ||
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway | Q37062266 | ||
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones | Q37202186 | ||
Extracellular, circulating proteasomes and ubiquitin - incidence and relevance | Q37207791 | ||
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology | Q37286190 | ||
NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease | Q37348985 | ||
Impaired assembly and post-translational regulation of 26S proteasome in human end-stage heart failure | Q37396042 | ||
Antigen presentation in the thymus for positive selection and central tolerance induction | Q37638193 | ||
The NF-kappaB family of transcription factors and its regulation | Q37672294 | ||
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. | Q37727657 | ||
Proteasome activators | Q37826501 | ||
Emerging roles of immunoproteasomes beyond MHC class I antigen processing | Q37989860 | ||
Degradation of damaged proteins: the main function of the 20S proteasome | Q38021167 | ||
Structural biology of the proteasome | Q38081952 | ||
The unique functions of tissue-specific proteasomes | Q38167099 | ||
Regulation of the proteasome: evaluating the lung proteasome as a new therapeutic target | Q38179456 | ||
The proteasome and the degradation of oxidized proteins: part III-Redox regulation of the proteasomal system | Q38190556 | ||
MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. | Q38345102 | ||
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival | Q38359163 | ||
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. | Q38393668 | ||
Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers. | Q39109956 | ||
The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1. | Q39155657 | ||
Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28 | Q39185542 | ||
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. | Q39315034 | ||
Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. | Q39352530 | ||
Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer | Q39411444 | ||
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation. | Q39580598 | ||
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. | Q39648354 | ||
P275 | copyright license | Creative Commons Attribution | Q6905323 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 3 | |
P921 | main subject | enzyme | Q8047 |
proteasome endopeptidase complex | Q13107625 | ||
ubiquitin-proteasome system | Q47175589 | ||
macromolecular substance | Q75174158 | ||
ubiquitins | Q76506155 | ||
P304 | page(s) | 862-884 | |
P577 | publication date | 2014-09-23 | |
P1433 | published in | Biomolecules | Q23929963 |
P1476 | title | Regulating the 20S proteasome ubiquitin-independent degradation pathway | |
P478 | volume | 4 |
Q33677593 | 20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death |
Q57026129 | A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome |
Q41757716 | A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function |
Q39414304 | AAA-ATPases in Protein Degradation. |
Q89446382 | Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome |
Q38840313 | Activity-based profiling of the proteasome pathway during hepatitis C virus infection |
Q90700693 | All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators |
Q98154545 | Arabidopsis COPPER TRANSPORTER 1 undergoes degradation in a proteasome-dependent manner |
Q58700644 | Biological consequences of structural and functional proteasome diversity |
Q53698101 | Biomarkers associated with low, moderate, and high vastus lateralis muscle hypertrophy following 12 weeks of resistance training. |
Q47103279 | Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome |
Q90357681 | CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a |
Q55401911 | Cationic porphyrins are tunable gatekeepers of the 20S proteasome. |
Q26741911 | Cellular Recycling of Proteins in Seed Dormancy Alleviation and Germination |
Q90228230 | Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes |
Q46268472 | Comparative Analysis of AGE and RAGE Levels in Human Somatic and Embryonic Stem Cells under H2O2-Induced Noncytotoxic Oxidative Stress Conditions |
Q93273338 | Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry |
Q36002378 | Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome |
Q42546531 | Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands |
Q36353641 | Control of Pim2 kinase stability and expression in transformed human haematopoietic cells |
Q41107536 | Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study |
Q90064937 | Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures |
Q41323221 | Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination |
Q92690890 | Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim |
Q92377236 | Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells |
Q47137426 | Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding. |
Q47390384 | Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis. |
Q47303553 | Functional regulation of proteins by 20S proteasome proteolytic processing |
Q41539407 | Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch |
Q42383178 | Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR. |
Q37043216 | Identification of Key Proteins and Networks Related to Grain Development in Wheat (Triticum aestivum L.) by Comparative Transcription and Proteomic Analysis of Allelic Variants in TaGW2-6A |
Q48227312 | Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70. |
Q92209807 | Intracellular Trafficking and Translocation of Pertussis Toxin |
Q47100880 | KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence |
Q94948572 | Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes |
Q47225050 | Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway |
Q39094217 | Mass Spectrometry: A Technique of Many Faces |
Q41788107 | Mcl-1 dynamics influence mitotic slippage and death in mitosis |
Q41622596 | Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea. |
Q38790062 | Methodological approaches and insights on protein aggregation in biological systems |
Q93049085 | Methods to Discover and Evaluate Proteasome Small Molecule Stimulators |
Q91554675 | Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts |
Q89982710 | NRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and Rb |
Q92613173 | Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development |
Q61816601 | On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation |
Q55559653 | Oncogenic addiction to high 26S proteasome level. |
Q90132188 | PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response |
Q47835030 | Post-translational regulation of p53 function through 20S proteasome-mediated cleavage. |
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Q28084015 | Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil |
Q47583613 | Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy |
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Q51679220 | Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. |
Q92923068 | Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer |
Q41623176 | Proteasomes: Isolation and Activity Assays. |
Q91663542 | Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity |
Q36177598 | Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes |
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Q90628179 | Repurposing Protein Degradation for Optogenetic Modulation of Protein Activities |
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Q91736712 | Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress |
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Q47354877 | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties. |
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Q40070954 | The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes |
Q64997878 | The Contribution of the 20S Proteasome to Proteostasis. |
Q38891820 | The Parkinson's-associated protein DJ-1 regulates the 20S proteasome. |
Q38996038 | The Proteasome Inhibition Model of Parkinson's Disease |
Q37194528 | The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation |
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