Regulating the 20S proteasome ubiquitin-independent degradation pathway

scientific article

Regulating the 20S proteasome ubiquitin-independent degradation pathway is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/BIOM4030862
P932PMC publication ID4192676
P698PubMed publication ID25250704
P5875ResearchGate publication ID266085909

P50authorMichal SharonQ21264412
P2093author name stringGili Ben-Nissan
P2860cites workIntrinsically unstructured proteins and their functionsQ22061731
Classification of intrinsically disordered regions and proteinsQ22061736
Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activityQ82066538
Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric formQ86045061
Ubiquitin-independent degradation of antiapoptotic MCL-1.Q39715640
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activationQ39760680
NADH binds and stabilizes the 26S proteasomes independent of ATP.Q39997925
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein traffickingQ40015705
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cellsQ40100471
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasomeQ40115986
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.Q40124637
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylationQ40323831
The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradationQ40484581
Association of immunoproteasomes with the endoplasmic reticulumQ40839103
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.Q40902473
Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation stateQ40984011
Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90.Q41027019
Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasomeQ41197961
Cytolocation of prosome antigens on intermediate filament subnetworks of cytokeratin, vimentin and desmin type.Q41485710
Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferonQ41810892
T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomesQ41923180
Redox control of 20S proteasome gatingQ42124117
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membraneQ42235376
Mechanism of direct degradation of IkappaBalpha by 20S proteasomeQ42482608
c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kineticsQ42576383
The nanny model for IDPs.Q43258539
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasomeQ43816254
Increased degradation of oxidized proteins in yeast defective in 26 S proteasome assemblyQ44082373
Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs.Q44123714
Proteasomal degradation of tau proteinQ44163168
20 S proteasome from Saccharomyces cerevisiae is responsive to redox modifications and is S-glutathionylatedQ44200243
Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathwayQ44251448
Approval summary for bortezomib for injection in the treatment of multiple myelomaQ44951957
Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasomeQ45023589
Heightened levels of circulating 20S proteasome in critically ill patients.Q46539143
Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasomeQ46627706
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stressQ24296668
The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasomeQ24302180
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancerQ24305235
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexQ24312855
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)Q24317177
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasomeQ24535198
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasomeQ24681597
Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyondQ26859368
Immunoproteasomes: structure, function, and antigen presentationQ27024527
Applied techniques for mining natural proteasome inhibitorsQ27026146
Structural basis for the activation of 20S proteasomes by 11S regulatorsQ27628418
Quinone reductase acts as a redox switch of the 20S yeast proteasomeQ27929880
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycleQ27930959
Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitinationQ27932737
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesisQ27933881
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
Regulation of CD8+ T cell development by thymus-specific proteasomesQ28116400
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysisQ28143710
Polo-like kinase interacts with proteasomes and regulates their activityQ28201240
Interaction of Hsp90 with 20S proteasome: thermodynamic and kinetic characterizationQ28214346
The role of the proteasome activator PA28 in MHC class I antigen processingQ28219263
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationQ28236609
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1Q28238115
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxiaQ28256645
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cellsQ28279454
The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive reviewQ28283466
Ubiquitin-independent degradation of proteins by the proteasomeQ28284043
Ubiquitin-independent proteasomal degradationQ28290917
Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in miceQ28291312
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expressionQ28293759
The testis-specific proteasome subunit Prosalpha6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesisQ47072730
Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activityQ48923815
Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methioninesQ49102090
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.Q50479449
Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro.Q52978719
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.Q53624251
Cell cycle-dependent caspase-like activity that cleaves p27KIP1 is the β1 subunit of the 20S proteasomeQ61043686
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)Q68127933
Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90Q71139075
Age-dependent association of isolated bovine lens multicatalytic proteinase complex (proteasome) with heat-shock protein 90, an endogenous inhibitorQ71557789
Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the proteinQ80086881
Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiationQ80379217
Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback LoopQ28295179
Proteome half-life dynamics in living human cellsQ28303198
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73Q28305429
Regulation of proteasome activity in health and diseaseQ28392708
Biological and chemical approaches to diseases of proteostasis deficiencyQ29616633
Protein degradation and protection against misfolded or damaged proteinsQ29618400
NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrestQ33627637
14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancerQ33705055
MDM2 promotes proteasomal degradation of p21Waf1 via a conformation changeQ33897779
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitinationQ33908311
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.Q33962101
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.Q34088438
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferaseQ34340947
Proteasome inhibitors: from research tools to drug candidatesQ34341985
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfoldedQ34426417
The axial channel of the 20S proteasome opens upon binding of the PA200 activatorQ34555139
Circulating proteasomes after burn injuryQ34665247
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 proteinQ34868376
Oxidative stress-mediated regulation of proteasome complexesQ34994401
Intracellular localization of proteasomesQ35097620
Regulation of the 26S proteasome complex during oxidative stressQ35120069
Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in miceQ35187068
Ubiquitin-independent proteasomal degradation during oncogenic viral infectionsQ35354212
Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogensQ35589124
The 26S proteasome complex: an attractive target for cancer therapyQ35624079
MDM2 and prognosis.Q35646484
Transformation of the proteasome with age-related macular degenerationQ35746946
Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stressQ35880062
The association of prosomes with some of the intermediate filament networks of the animal cellQ36219352
Dynamic association of proteasomal machinery with the centrosomeQ36342153
NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative diseaseQ36451851
Subcellular distribution and dynamics of active proteasome complexes unraveled by a workflow combining in vivo complex cross-linking and quantitative proteomics.Q36666357
Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neuronsQ36796902
Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosusQ36898023
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.Q36945044
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling PathwayQ37062266
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histonesQ37202186
Extracellular, circulating proteasomes and ubiquitin - incidence and relevanceQ37207791
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiologyQ37286190
NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative diseaseQ37348985
Impaired assembly and post-translational regulation of 26S proteasome in human end-stage heart failureQ37396042
Antigen presentation in the thymus for positive selection and central tolerance inductionQ37638193
The NF-kappaB family of transcription factors and its regulationQ37672294
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.Q37727657
Proteasome activatorsQ37826501
Emerging roles of immunoproteasomes beyond MHC class I antigen processingQ37989860
Degradation of damaged proteins: the main function of the 20S proteasomeQ38021167
Structural biology of the proteasomeQ38081952
The unique functions of tissue-specific proteasomesQ38167099
Regulation of the proteasome: evaluating the lung proteasome as a new therapeutic targetQ38179456
The proteasome and the degradation of oxidized proteins: part III-Redox regulation of the proteasomal systemQ38190556
MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.Q38345102
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress.Q38393668
Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers.Q39109956
The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.Q39155657
Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28Q39185542
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.Q39315034
Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins.Q39352530
Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancerQ39411444
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.Q39580598
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes.Q39648354
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectenzymeQ8047
proteasome endopeptidase complexQ13107625
ubiquitin-proteasome systemQ47175589
macromolecular substanceQ75174158
ubiquitinsQ76506155
P304page(s)862-884
P577publication date2014-09-23
P1433published inBiomoleculesQ23929963
P1476titleRegulating the 20S proteasome ubiquitin-independent degradation pathway
P478volume4

Reverse relations

cites work (P2860)
Q3367759320S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death
Q57026129A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome
Q41757716A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function
Q39414304AAA-ATPases in Protein Degradation.
Q89446382Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome
Q38840313Activity-based profiling of the proteasome pathway during hepatitis C virus infection
Q90700693All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators
Q98154545Arabidopsis COPPER TRANSPORTER 1 undergoes degradation in a proteasome-dependent manner
Q58700644Biological consequences of structural and functional proteasome diversity
Q53698101Biomarkers associated with low, moderate, and high vastus lateralis muscle hypertrophy following 12 weeks of resistance training.
Q47103279Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome
Q90357681CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a
Q55401911Cationic porphyrins are tunable gatekeepers of the 20S proteasome.
Q26741911Cellular Recycling of Proteins in Seed Dormancy Alleviation and Germination
Q90228230Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes
Q46268472Comparative Analysis of AGE and RAGE Levels in Human Somatic and Embryonic Stem Cells under H2O2-Induced Noncytotoxic Oxidative Stress Conditions
Q93273338Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry
Q36002378Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome
Q42546531Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
Q36353641Control of Pim2 kinase stability and expression in transformed human haematopoietic cells
Q41107536Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study
Q90064937Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures
Q41323221Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination
Q92690890Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim
Q92377236Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells
Q47137426Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.
Q47390384Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.
Q47303553Functional regulation of proteins by 20S proteasome proteolytic processing
Q41539407Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch
Q42383178Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
Q37043216Identification of Key Proteins and Networks Related to Grain Development in Wheat (Triticum aestivum L.) by Comparative Transcription and Proteomic Analysis of Allelic Variants in TaGW2-6A
Q48227312Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70.
Q92209807Intracellular Trafficking and Translocation of Pertussis Toxin
Q47100880KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence
Q94948572Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes
Q47225050Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway
Q39094217Mass Spectrometry: A Technique of Many Faces
Q41788107Mcl-1 dynamics influence mitotic slippage and death in mitosis
Q41622596Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea.
Q38790062Methodological approaches and insights on protein aggregation in biological systems
Q93049085Methods to Discover and Evaluate Proteasome Small Molecule Stimulators
Q91554675Mild proteasomal stress improves photosynthetic performance in Arabidopsis chloroplasts
Q89982710NRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and Rb
Q92613173Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
Q61816601On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation
Q55559653Oncogenic addiction to high 26S proteasome level.
Q90132188PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
Q47835030Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.
Q88532421Posttranslational regulation of CYP2J2 by nitric oxide
Q28084015Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil
Q47583613Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy
Q92157489Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders
Q92454652Proteasome Activation to Combat Proteotoxicity
Q58567864Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used
Q51679220Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.
Q92923068Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer
Q41623176Proteasomes: Isolation and Activity Assays.
Q91663542Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity
Q36177598Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes
Q90044520Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Q60925253Regulation of Protein Degradation by Proteasomes in Cancer
Q58751591Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)
Q90673658Regulation of proteasome assembly and activity in health and disease
Q90628179Repurposing Protein Degradation for Optogenetic Modulation of Protein Activities
Q92453497Saga of Mcl-1: regulation from transcription to degradation
Q48105748Sem1 links proteasome stability and specificity to multicellular development.
Q47141859Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins
Q89087470Small Molecule Modulation of Proteasome Assembly
Q91736712Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress
Q93382475State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research
Q47354877Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
Q35998619Substituted quinolines as noncovalent proteasome inhibitors.
Q38799873The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System
Q40070954The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes
Q64997878The Contribution of the 20S Proteasome to Proteostasis.
Q38891820The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.
Q38996038The Proteasome Inhibition Model of Parkinson's Disease
Q37194528The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation
Q95650650The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
Q44571594The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress
Q34535073The ubiquitin-proteasome system and autophagy: Coordinated and independent activities
Q38559265Tuning the proteasome to brighten the end of the journey
Q36799938Uncommon functional properties of the first piscine 26S proteasome from the Antarctic notothenioid Trematomus bernacchii
Q64069427Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis
Q52651294Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.

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