An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis

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An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis is …
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scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112E1763J
P356DOI10.1073/PNAS.1423319112
P932PMC publication ID4394314
P698PubMed publication ID25831519
P5875ResearchGate publication ID274400004

P50authorHuib OvaaQ28320514
Steven P. GygiQ88679013
K Heran DarwinQ95968250
Jordan B. JastrabQ110692065
P2093author name stringTong Wang
Lin Bai
Huilin Li
Champak Chatterjee
J Patrick Murphy
Jessica Huang
Kuan Hu
Remco Merkx
P2860cites workHigh-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolismQ21131409
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Mechanism of gate opening in the 20S proteasome by the proteasomal ATPasesQ24564109
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entryQ24674433
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Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactionsQ27646619
Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase MpaQ27657813
Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate OpeningQ27660222
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasomeQ27661499
Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradationQ27665108
An Archaeal Homolog of Proteasome Assembly Factor Functions as a Proteasome ActivatorQ27677216
Molecular architecture and assembly of the eukaryotic proteasomeQ27693890
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanismQ27931319
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particleQ27938094
Genes required for mycobacterial growth defined by high density mutagenesisQ27976512
Purification of an 11 S regulator of the multicatalytic proteaseQ28202111
In vivo half-life of a protein is a function of its amino-terminal residueQ28287702
Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.Q28363065
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificityQ28486412
Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosisQ28486486
Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymesQ28486639
A novel copper-responsive regulon in Mycobacterium tuberculosisQ28486641
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genesQ28486842
The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminusQ28486892
Identification of substrates of the Mycobacterium tuberculosis proteasomeQ28487088
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosisQ28487196
Bacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasomeQ28487276
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxideQ28487442
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologueQ28487523
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected]Q28487609
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in miceQ28909142
Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperonesQ28909145
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatisQ29614369
STRING v9.1: protein-protein interaction networks, with increased coverage and integrationQ29614691
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxideQ33658714
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.Q33987362
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.Q33991996
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The lon Gene and Degradation of β-Galactosidase Nonsense FragmentsQ34699404
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor bindingQ34928089
The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La.Q35460779
lon gene product of Escherichia coli is a heat-shock proteinQ36301710
Deg phenotype of Escherichia coli lon mutantsQ36418299
Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome).Q36444744
REGγ deficiency promotes premature aging via the casein kinase 1 pathwayQ36990873
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagyQ37269271
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Structural biology of the proteasomeQ38081952
Machines of destruction - AAA+ proteases and the adaptors that control them.Q38088218
The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulonQ38327829
A role for the proteasome regulator PA28alpha in antigen presentationQ38357921
Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
Intermediate steps in the degradation of a specific abnormal protein in Escherichia coliQ40829271
Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteriaQ41036842
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.Q41063926
The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitroQ41283840
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronateQ41626376
Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma bruceiQ41703202
DnaK dependence of the mycobacterial stress-responsive regulator HspR is mediated through its hydrophobic C-terminal tailQ42182867
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Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signalsQ44384522
Immune defects in 28-kDa proteasome activator gamma-deficient miceQ44788682
Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.Q47379441
26S proteasome structure revealed by three-dimensional electron microscopyQ48941878
Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infectionQ58231674
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)Q68127933
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activatorsQ73770368
P4510describes a project that usesImageQuantQ112270642
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectadenosine triphosphateQ80863
Mycobacterium tuberculosisQ130971
P304page(s)E1763-72
P577publication date2015-03-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAn adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis
P478volume112