Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

scientific article published on 27 August 2019

Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41380-019-0498-X
P698PubMed publication ID31455858

P50authorZhen YanQ88033022
P2093author name stringWei Wang
Ping Zhong
Xue Wang
Jun Qu
Kaijie Ma
Luye Qin
Maximiliano Rapanelli
Tao Tan
Zi-Jun Wang
Luciana Frick
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Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movementQ24318748
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Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disordersQ26853035
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Synaptic, transcriptional and chromatin genes disrupted in autismQ28250800
Association between microdeletion and microduplication at 16p11.2 and autismQ28264205
Constitutive turnover of cyclin E by Cul3 maintains quiescenceQ28506695
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptorQ28975781
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutationsQ29030218
Meeting of minds: the medial frontal cortex and social cognitionQ29614739
The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPaseQ30438135
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Patches of disorganization in the neocortex of children with autismQ34040334
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Recurrent 16p11.2 microdeletions in autismQ34729775
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Q37163747
A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell GrowthQ37183416
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?Q37444933
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autismQ37716254
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Striatal circuits, habits, and implications for obsessive-compulsive disorder.Q38252883
Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder.Q41173126
Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin RegulatorsQ42018247
Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseasesQ42164701
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biasesQ42175057
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.Q42524386
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligasesQ42694183
Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neuronsQ44463501
Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis.Q45902314
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior.Q46407810
Sensorimotor gating deficits in adults with autismQ46422161
Kctd13 deletion reduces synaptic transmission via increased RhoA.Q47035966
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.Q47284253
A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation.Q48265883
Changes in the development of striatum are involved in repetitive behavior in autismQ48959458
Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse.Q52201737
Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibitionQ60357933
Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome.Q64948646
Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and RhoQ73010224
P577publication date2019-08-27
P1433published inMolecular PsychiatryQ6895973
P1476titleBehavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3

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cites work (P2860)
Q99207743A standardized social preference protocol for measuring social deficits in mouse models of autism
Q100311434Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics
Q89882718Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

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