Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

scientific article

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1016032465
P356DOI10.1038/NATURE05506
P698PubMed publication ID17287809

P50authorRobert MalenkaQ16731868
P2093author name stringAnatol C Kreitzer
P2860cites workSynaptic organisation of the basal gangliaQ24544917
Short-term synaptic plasticityQ28217342
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brainQ28259933
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampusQ28268567
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout miceQ28343324
Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptorsQ28512698
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptorsQ28587334
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
The functional anatomy of basal ganglia disordersQ29617461
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
Practice parameter: thymectomy for autoimmune myasthenia gravis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of NeurologyQ33966346
The basal gangliaQ33970931
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.Q34521936
Animal models of Parkinson's disease.Q34596189
It could be habit forming: drugs of abuse and striatal synaptic plasticity.Q35104780
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brainsQ38315630
Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelaeQ41173089
Dopamine activation of endogenous cannabinoid signaling in dorsal striatumQ41646203
Long-term synaptic depression in the striatum: physiological and pharmacological characterizationQ42453585
Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats.Q42493069
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumQ43971441
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.Q44102387
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.Q46279749
P433issue7128
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
striatumQ1319792
endocannabinoidsQ10483908
P304page(s)643-647
P577publication date2007-02-01
P1433published inNatureQ180445
P1476titleEndocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
P478volume445

Reverse relations

cites work (P2860)
Q47229964A High-fat, High-sugar 'Western' Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice.
Q30485219A cAMP pathway underlying reward prediction in associative learning
Q36168175A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice
Q57296786A competitive model for striatal action selection
Q36940413A molecular switch for induction of long-term depression of corticostriatal transmission
Q34629593A neurocomputational account of catalepsy sensitization induced by D2 receptor blockade in rats: context dependency, extinction, and renewal
Q39502291A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.
Q48810494A simple method for characterizing passive and active neuronal properties: application to striatal neurons
Q27324171A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice
Q37581600Acute and chronic effects of ethanol on learning-related synaptic plasticity.
Q36978473Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons
Q28541409Adaptive gene regulation in the Striatum of RGS9-deficient mice
Q35056410Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function
Q35607243Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion.
Q28286488Adenosine-cannabinoid receptor interactions. Implications for striatal function
Q42668061Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning
Q38123275Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems
Q24657764Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease
Q37161459Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein
Q47555397Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model.
Q35055022Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease
Q60934814Altered Synaptic Vesicle Release and Ca Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington's Disease
Q35078309Altered hippocampal synaptic physiology in aged parkin-deficient mice
Q35039492An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons
Q28748890Anatomy of a songbird basal ganglia circuit essential for vocal learning and plasticity
Q36248857Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.
Q42520592Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats
Q64782437Are we listening to everything the PARK genes are telling us?
Q45185178Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
Q93123575Axonal degeneration in Parkinson's disease - Basal ganglia circuitry and D2 receptor availability
Q30423739Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome
Q92914169Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3
Q50055065Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD.
Q91959308Biological bases for a possible effect of cannabidiol in Parkinson's disease
Q92572721Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
Q36759329Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation
Q36797226CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
Q42493834Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons
Q91046020Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior
Q37734568Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders.
Q38522769Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia
Q40701861Cannabinoids for the Treatment of Movement Disorders.
Q42258332Cannabinoids in Parkinson's Disease
Q24633884Cannabinoids in health and disease
Q34699888Cannabis, the mind and society: the hash realities
Q30650489Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
Q34183765Cell type-specific synaptic encoding of ethanol exposure in the nucleus accumbens shell
Q90140618Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models
Q33711360Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons.
Q38212230Cerebellar influence on motor cortex plasticity: behavioral implications for Parkinson's disease
Q38809530Chronic Nicotine Alters Corticostriatal Plasticity in the Striatopallidal Pathway Mediated By NR2B-Containing Silent Synapses
Q36889608Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency
Q34358086Chronic THC intake modifies fundamental cerebellar functions
Q42481102Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.
Q38598509Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
Q40742869Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function.
Q47799371Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways
Q36927168Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).
Q48130770Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression.
Q30495714Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors
Q41169632Computing reward-prediction error: an integrated account of cortical timing and basal-ganglia pathways for appetitive and aversive learning
Q92886078Control of glutamate release by complexes of adenosine and cannabinoid receptors
Q42441040Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum
Q33756951Convergent evidence for abnormal striatal synaptic plasticity in dystonia
Q36445234Convergent mechanisms in etiologically-diverse dystonias
Q42479388Cortical and thalamic innervation of direct and indirect pathway medium-sized spiny neurons in mouse striatum.
Q24648260Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.
Q42551042Corticostriatal and thalamostriatal synapses have distinctive properties
Q34315364Corticostriatal projection neurons – dichotomous types and dichotomous functions
Q45306738Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load
Q48093702Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
Q33575226Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons
Q46095429D2R striatopallidal neurons inhibit both locomotor and drug reward processes
Q43073344Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia
Q64251973Delayed Spine Pruning of Direct Pathway Spiny Projection Neurons in a Mouse Model of Parkinson's Disease
Q42178082Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors
Q37129354Dendritic excitability and synaptic plasticity
Q41904397Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease
Q43287350Developmental alterations of DHPG-induced long-term depression of corticostriatal synaptic transmission: switch from NMDA receptor-dependent towards CB1 receptor-dependent plasticity
Q34007247Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
Q35607269Dichotomous anatomical properties of adult striatal medium spiny neurons
Q30493521Dichotomous dopaminergic control of striatal synaptic plasticity
Q33944484Different corticostriatal integration in spiny projection neurons from direct and indirect pathways
Q36122543Differential CaMKII regulation by voltage-gated calcium channels in the striatum
Q53446566Differential Synaptic Remodeling by Dopamine in Direct and Indirect Striatal Projection Neurons in Pitx3-/- Mice, a Genetic Model of Parkinson's Disease.
Q48340405Differential cortical activation of the striatal direct and indirect pathway cells: reconciling the anatomical and optogenetic results by using a computational method
Q35922870Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice.
Q34764514Differential electrophysiological changes in striatal output neurons in Huntington's disease.
Q44463501Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons
Q37185190Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine?
Q46782245Differential tonic GABA conductances in striatal medium spiny neurons
Q38234309Direct and indirect pathways of basal ganglia: a critical reappraisal
Q42734818Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum
Q41220847Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection
Q42852538Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.
Q33720464Distinct roles of GABAergic interneurons in the regulation of striatal output pathways
Q38593117Distribution of the Endocannabinoid System in the Central Nervous System
Q41899842Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia.
Q34780457Dopamine D2 receptor overexpression alters behavior and physiology in Drd2-EGFP mice
Q37629163Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
Q42579414Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons
Q24300992Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia
Q38121068Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility
Q42444141Dopamine-dependent long-term depression at subthalamo-nigral synapses is lost in experimental parkinsonism
Q48114419Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease.
Q57295457Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
Q34726418Dopamine-mediated learning and switching in cortico-striatal circuit explain behavioral changes in reinforcement learning
Q28972550Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide
Q30475711Dopaminergic dysfunction in schizophrenia: salience attribution revisited.
Q34001324Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex
Q92773981Dopaminergic modulation of striatal function and Parkinson's disease
Q38233462Dopaminergic modulation of striatal networks in health and Parkinson's disease
Q26862387Dopaminergic modulation of striatal neurons, circuits, and assemblies
Q35282100Dopaminergic modulation of synaptic transmission in cortex and striatum
Q36744457Dopaminergic signaling in dendritic spines
Q35044956Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning
Q42525723Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia.
Q34166000Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Q34509725Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light
Q58749186Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons
Q37415294Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill.
Q38722989Dysregulation of striatal projection neurons in Parkinson's disease
Q36916041Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum.
Q37398453Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum
Q41557765Electrophysiological Measurement of Cannabinoid-Mediated Synaptic Modulation in Acute Mouse Brain Slices
Q64097566Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and Female -tdTomato Line 6 BAC Transgenic Mice
Q89428319Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice
Q90369314Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Q38018946Endocannabinoid modulation of dopaminergic motor circuits.
Q35679432Endocannabinoid signaling and long-term synaptic plasticity.
Q37262759Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
Q39353443Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
Q39368845Endocannabinoid system in neurodegenerative disorders.
Q47570978Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model
Q35898412Endocannabinoid-dopamine interactions in striatal synaptic plasticity
Q37363621Endocannabinoid-mediated control of synaptic transmission
Q37870597Endocannabinoids and retrograde modulation of synaptic transmission
Q36686382Endocannabinoids in striatal plasticity
Q34084682Endocannabinoids in synaptic plasticity and neuroprotection
Q30762059Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling.
Q34797508Ethanol affects striatal interneurons directly and projection neurons through a reduction in cholinergic tone
Q34413842Excitability decreasing central motor plasticity is retained in multiple sclerosis patients.
Q37422261Excitatory and inhibitory synapses in neuropeptide Y-expressing striatal interneurons
Q34351068Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease.
Q34330022Extrastriatal dopaminergic circuits of the Basal Ganglia
Q28285103Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders
Q41479982From real-world events to psychosis: the emerging neuropharmacology of delusions
Q27015687Functional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's Disease
Q37112496Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity
Q60917742Functional and behavioral consequences of Parkinson's disease-associated G2019S mutation
Q28589264Functional disturbances in the striatum by region-specific ablation of NMDA receptors
Q22252880Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease
Q50200300Functional relevance of endocannabinoid-dependent synaptic plasticity in the CNS.
Q48698997Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network
Q42175447Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia
Q37170603Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice.
Q46446129Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.
Q28469322Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
Q24674131Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning
Q39890360GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation
Q24620534Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease
Q37036614Habenula: crossroad between the basal ganglia and the limbic system
Q37532356Habit Formation after Random Interval Training Is Associated with Increased Adenosine A2A Receptor and Dopamine D2 Receptor Heterodimers in the Striatum
Q48541253Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits
Q41883668Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum.
Q24652245Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
Q37395798High on habits
Q34763903High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
Q38753843Hippocampal metabotropic glutamate receptor long-term depression in health and disease: focus on mitogen-activated protein kinase pathways.
Q53273194Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors.
Q41814232Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.
Q33500170Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion
Q33999262Immunohistochemical localization of AMPA-type glutamate receptor subunits in the striatum of rhesus monkey
Q30578265Impaired fear memory specificity associated with deficient endocannabinoid-dependent long-term plasticity
Q37610892Implicit learning in aging: extant patterns and new directions
Q33751118In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability
Q91967111Indirect Medium Spiny Neurons in the Dorsomedial Striatum Regulate Ethanol-Containing Conditioned Reward Seeking
Q41852040Induction of cannabinoid- and N-methyl-D-aspartate receptor-mediated long-term depression in the nucleus accumbens and dorsolateral striatum is region and age dependent
Q28387521Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation
Q39801798Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia.
Q33996977Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels
Q46059093Inhibitory contribution to suprathreshold corticostriatal responses: an experimental and modeling study
Q42268862Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
Q42470816Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum.
Q24632803Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia
Q34029003Integrating synaptic plasticity and striatal circuit function in addiction
Q45218750Intratelencephalic corticostriatal neurons equally excite striatonigral and striatopallidal neurons and their discharge activity is selectively reduced in experimental parkinsonism
Q35932567Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements
Q27026279Investigating striatal function through cell-type-specific manipulations
Q52655473Kainate Receptors Inhibit Glutamate Release Via Mobilization of Endocannabinoids in Striatal Direct Pathway Spiny Projection Neurons.
Q54707901Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway.
Q42467623LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory
Q27002626Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?
Q58868609Long-Lasting NMDA Receptor-Mediated EPSCs in Mouse Striatal Medium Spiny Neurons
Q88513707Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease
Q44345217Long-term plasticity of corticostriatal synapses is modulated by pathway-specific co-release of opioids through κ-opioid receptors
Q24658338Looking for the role of cannabinoid receptor heteromers in striatal function
Q39735904Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease.
Q36861976Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat.
Q36892615M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia
Q37516434Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia
Q37512670Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy.
Q46108447Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult
Q34613020Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine
Q40313187Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats.
Q43100078Metaplasticity of hypothalamic synapses following in vivo challenge
Q34749047Milestones in research on the pathophysiology of Parkinson's disease
Q96228741Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease
Q36367283Modulation of striatal projection systems by dopamine
Q26830654Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
Q50069504Molecular insights into cortico-striatal miscommunications in Huntington's disease
Q37629974Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future
Q47569238Motor learning and metaplasticity in striatal neurons: relevance for Parkinson's disease
Q38739709Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex
Q36940345Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models
Q42481097NEUROSCIENCE. Astrocytes tell neurons when to listen up.
Q37132571Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2
Q37308026Neurocomputational models of basal ganglia function in learning, memory and choice
Q37778902Neurocomputational models of motor and cognitive deficits in Parkinson's disease
Q37844744Neuromodulatory control of striatal plasticity and behavior.
Q22241960Neuronal Reward and Decision Signals: From Theories to Data
Q47326858Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism.
Q37680104Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum
Q36074595New insights on endocannabinoid transmission in psychomotor disorders
Q38038559New synaptic and molecular targets for neuroprotection in Parkinson's disease
Q42789671Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease.
Q41809772Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats.
Q42785592Nitric Oxide-Soluble Guanylyl Cyclase-Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?
Q36914301Npas1+ Pallidal Neurons Target Striatal Projection Neurons
Q90196706Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling
Q46570512Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
Q41791746Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons
Q35575588Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling
Q91790352Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits
Q33955359Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function.
Q33714587Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications
Q55255522Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons.
Q41866674P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices
Q37705771Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
Q64911660Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood.
Q37930190Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.
Q44342408Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity
Q50092568Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors.
Q36512106Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors
Q94599920Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission
Q55111952Pharmacological Blockade of Adenosine A2A but Not A1 Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior.
Q35166968Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum
Q36031693Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene
Q43704187Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release.
Q27011417Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
Q30500199Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
Q42509576Predicting the response of striatal spiny neurons to sinusoidal input.
Q34390849Prenatal ethanol exposure alters synaptic plasticity in the dorsolateral striatum of rat offspring via changing the reactivity of dopamine receptor
Q26853387Preservation of function in Parkinson's disease: what's learning got to do with it?
Q35762827Presynaptic LTP and LTD of excitatory and inhibitory synapses
Q35039222Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Q38557880Probing striatal microcircuitry to understand the functional role of cholinergic interneurons
Q35499568Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection
Q60949363Proteomic Profile of Carbonylated Proteins Screen Regulation of Apoptosis via CaMK Signaling in Response to Regular Aerobic Exercise
Q92885571RETRACTED ARTICLE: Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism
Q30504550RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits
Q38366676Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine.
Q39732881Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease
Q34961512Regulation of dendritic calcium release in striatal spiny projection neurons
Q24630976Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Q36754113Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits
Q41518121Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
Q33362024Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle
Q30497841Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.
Q28394979Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition
Q49834838Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior
Q39190510Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events
Q48720514SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
Q36008922Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity
Q35075199Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning.
Q36535361Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine.
Q35040674Serotonin induces long-term depression at corticostriatal synapses
Q34560043Short latency cerebellar modulation of the basal ganglia
Q34554544Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function
Q28707279Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: a combined PET, fMRI and DTI study
Q64086843Spiny Projection Neuron Dynamics in Toxin and Transgenic Models of Parkinson's Disease
Q36288401Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice
Q42099006Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.
Q37925513Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation.
Q39414543Striatal cholinergic interneurons and Parkinson's disease.
Q38271951Striatal direct and indirect pathways control decision-making behavior.
Q21143854Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice
Q37336143Striatal plasticity and basal ganglia circuit function
Q36763909Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
Q48138673Striatal synapses, circuits, and Parkinson's disease
Q40936456Striatopallidal Neuron NMDA Receptors Control Synaptic Connectivity, Locomotor, and Goal-Directed Behaviors
Q30008746Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism
Q64866431Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases
Q37346328Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice
Q39381131Synaptic functions of endocannabinoid signaling in health and disease
Q22337221Synaptic plasticity and addiction
Q37702356Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse
Q28242702Synaptic plasticity: multiple forms, functions, and mechanisms
Q37578353Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum
Q37098652Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
Q37031746Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites
Q30474602Targeting neuronal populations of the striatum
Q90053610Targeting the cholinergic system in Parkinson's disease
Q37150745Targeting the endocannabinoid system: to enhance or reduce?
Q60715991The Distinct Role of Medium Spiny Neurons and Cholinergic Interneurons in the D2/A2A Receptor Interaction in the Striatum: Implications for Parkinson's Disease
Q30498111The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction
Q36943239The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms
Q92957609The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens
Q61804251The Role of Lipids in Parkinson's Disease
Q55427881The adjustment of γ-aminobutyric acidA tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum.
Q53076152The antipsychotic landscape: dopamine and beyond.
Q42495608The bright side of psychoactive substances: cannabinoid-based drugs in motor diseases.
Q35740152The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats
Q34267133The decrease of dopamine D₂/D₃ receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB₁ cannabinoid receptors in Parkinson's disease: a preliminary autoradiographic study with the selective dopamine D₂/D₃ an
Q36630516The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing
Q37394164The endocannabinoid system as a target for the treatment of motor dysfunction
Q34098196The endocannabinoid system as a target for the treatment of neurodegenerative disease
Q28264155The ins and outs of the striatum: role in drug addiction
Q34660573The major central endocannabinoid directly acts at GABA(A) receptors
Q88150069The missing, the short, and the long: Levodopa responses and dopamine actions
Q45923772The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway.
Q40663529The role of dopamine in modulating the structure and function of striatal circuits.
Q33687660The role of dopamine in risk taking: a specific look at Parkinson's disease and gambling
Q38099197The role of neuroplasticity in dopaminergic therapy for Parkinson disease.
Q30499665The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum
Q37910746The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
Q35171113The therapeutic potential of cannabinoids for movement disorders
Q37402927The therapeutic potential of novel cannabinoid receptors
Q36957968Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.
Q58090420Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders
Q47838280Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons.
Q49169649Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
Q48873079Toward a model of retrograde regulation of striatal synaptic depression.
Q48355383URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors
Q41431345Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model
Q37400352Updating dopamine reward signals
Q37687946Utility of genetically modified mice for understanding the neurobiology of substance use disorders
Q37371387WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Q38153344What can we learn about schizophrenia from studying the human model, drug-induced psychosis?
Q34201532What is the degree of segregation between striatonigral and striatopallidal projections?
Q35574934Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia
Q33771857mGluR-mediated and endocannabinoid-dependent long-term depression in the hilar region of the rat dentate gyrus