The therapeutic potential of cannabinoids for movement disorders

scientific article

The therapeutic potential of cannabinoids for movement disorders is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/MDS.26142
P932PMC publication ID4357541
P698PubMed publication ID25649017

P50authorJoseph JankovicQ6284337
Benzi M KlugerQ64856652
P2093author name stringWallace Jones
Piera Triolo
P2860cites workCannabinoid effects in basal ganglia in a rat model of Parkinson's diseaseQ48435185
The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesiaQ48890770
The clinical features of psychogenic movement disorders resembling tics.Q51183278
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamstersQ51620133
A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis.Q51853893
Effective treatment of Tourette's syndrome with marijuana.Q53986251
Cannabinoid, CB1 agonists in cervical dystonia: Failure in a phase IIa randomized controlled trialQ57083745
Marijuana and Tourette's syndromeQ68049272
Dopaminergic regulation of cannabinoid receptor mRNA levels in the rat caudate-putamen: an in situ hybridization studyQ72656516
Tetrahydrocannabinol potentiates reserpine-induced hypokinesiaQ72916142
Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinolQ74611800
A dramatic response to inhaled cannabis in a woman with central thalamic pain and dystoniaQ74619834
Cannabis-induced propriospinal myoclonusQ80201669
Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeysQ80609691
Cannabis sativa and dystonia secondary to Wilson's diseaseQ80609849
Cannabinoids improve driving ability in a Tourette's patientQ84336229
Synthetic cannabinoid overdose in a 20-year-old male US soldierQ85911058
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptorQ21093349
Cannabinoids for Tourette's SyndromeQ24240148
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blockerQ24601670
Human cannabinoid pharmacokineticsQ24652736
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disordersQ26823267
Adverse health effects of marijuana useQ26861513
Cannabinoids control spasticity and tremor in a multiple sclerosis modelQ28138564
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
The enigmatic pharmacology of GPR55Q28235873
Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis miceQ28250525
Identification and functional characterization of brainstem cannabinoid CB2 receptorsQ28276972
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors.Q33845285
Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trialQ33958602
Treatment of Tourette syndrome with delta-9-tetrahydrocannabinol (delta 9-THC): no influence on neuropsychological performanceQ33964368
Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.Q33965686
Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severityQ34002281
Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.Q34025116
Open label evaluation of cannabidiol in dystonic movement disordersQ34050762
Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.Q34098292
Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystoniaQ34113369
Therapeutic aspects of cannabis and cannabinoidsQ34130996
Psychogenic tremor: a video guide to its distinguishing featuresQ34169551
Cannabinoid modulation of the dopaminergic circuitry: implications for limbic and striatal outputQ34248777
Endocannabinoid signaling and synaptic functionQ34304094
The pharmacologic and clinical effects of medical cannabis.Q34326515
Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptomsQ34349067
Effects of CB1 cannabinoid receptor modulating compounds on the hyperkinesia induced by high-dose levodopa in the reserpine-treated rat model of Parkinson's diseaseQ44285779
Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonismQ44418544
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonateQ44511287
Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid functionQ44793025
Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseQ44931450
Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.Q45217300
Controlled clinical trial of cannabidiol in Huntington's diseaseQ45293556
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.Q45297533
Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivoQ45299326
Nabilone increases choreatic movements in Huntington's diseaseQ45299472
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's diseaseQ45300428
The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum.Q45302088
Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease.Q45303268
Nabilone could treat chorea and irritability in Huntington's diseaseQ45303424
Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's diseaseQ45305400
Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonismQ45310537
The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease.Q46026291
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients.Q46456086
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's diseaseQ46491157
The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's diseaseQ46552546
Therapeutic effects of Delta9-THC and modafinil in a marmoset Parkinson modelQ46789289
Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndromeQ46859134
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trialQ48065074
Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptorsQ48087305
Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case seriesQ48105623
Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brainQ48139478
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory actionQ48309971
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent propertiesQ48324018
Colorado tackles medical implications of marijuanaQ48367047
Endocannabinoid modulation of dopaminergic motor circuits.Q38018946
Treatment of Tourette syndrome with cannabinoidsQ38063066
The pathophysiology of symptomatic propriospinal myoclonusQ38224389
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's diseaseQ39365419
The effect of cannabis on tremor in patients with multiple sclerosisQ39381983
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's diseaseQ40358139
Prevalence and correlates of drug use and dependence in the United States. Results from the National Comorbidity SurveyQ40992443
Marijuana for parkinsonian tremorQ41369366
Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunctionQ41968489
Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonismQ42095959
The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned ratsQ42445636
Adjuncts to dopamine replacement: a pragmatic approach to reducing the problem of dyskinesia in Parkinson's diseaseQ42464432
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamenQ42487505
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.Q42500348
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.Q42517324
Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.Q42624110
Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1).Q42646021
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's diseaseQ42695373
Effects of cannabinoid CB1 receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeysQ42844506
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's diseaseQ42851005
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned ratsQ42871461
Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice.Q42988084
Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case reportQ43045883
A pilot study using nabilone for symptomatic treatment in Huntington's diseaseQ43257764
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.Q43266820
Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned ratsQ43425029
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's diseaseQ43669613
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.Q43683165
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot studyQ43820144
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.Q44102387
Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesiaQ44209138
Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's diseaseQ44237885
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover studyQ34358022
Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational studyQ34409345
Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of NeurologyQ34417710
Probability and predictors of the cannabis gateway effect: a national studyQ34435738
Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndromeQ34486318
Cannabinoid function in learning, memory and plasticityQ34510858
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trialQ34543217
Effect of cannabinoids on spasticity and ataxia in multiple sclerosisQ34676919
Tetrahydrocannabinol for tremor in multiple sclerosisQ34708416
The perceived effects of smoked cannabis on patients with multiple sclerosisQ34742477
Cannabidiol for the treatment of psychosis in Parkinson's diseaseQ34830827
Cannabis smoking and risk of lung cancer in men: a pooled analysis of three studies in MaghrebQ34895727
Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's diseaseQ35193305
The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated ratsQ35740152
Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.Q36056302
Cannabinoid-based drugs as anti-inflammatory therapeuticsQ36111923
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.Q36248857
Sensory aspects of movement disordersQ36595746
Endocannabinoids in basal ganglia circuits: implications for Parkinson diseaseQ36884599
Modulating the endocannabinoid system in human health and disease--successes and failuresQ36933683
Pharmacokinetic and pharmacodynamic profile of supratherapeutic oral doses of Δ(9) -THC in cannabis usersQ36951509
Cannabinoids and neuroprotection in basal ganglia disorders.Q36977766
Steppingstone and gateway ideas: a discussion of origins, research challenges, and promising lines of research for the futureQ36989649
The seek of neuroprotection: introducing cannabinoids.Q37067463
Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.Q37253331
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Q37371387
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depressionQ37414566
Designing clinical trials for dystoniaQ37506514
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitationQ37532968
Anandamide and the vanilloid receptor (TRPV1).Q37568663
Cannabinoids and neurodegenerative diseasesQ37617447
Prevalence and correlates of alcohol and cannabis use disorders in the United States: results from the national longitudinal study of adolescent healthQ37658318
The Multiplicity of Action of Cannabinoids: Implications for Treating NeurodegenerationQ37793366
Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicineQ37871980
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcannabinoidsQ422936
P304page(s)313-327
P577publication date2015-02-04
P1433published inMovement DisordersQ1486418
P1476titleThe therapeutic potential of cannabinoids for movement disorders
P478volume30

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cites work (P2860)
Q42087548A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease
Q47101767A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders
Q38392800A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease.
Q36157657Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?
Q40701861Cannabinoids for the Treatment of Movement Disorders.
Q42258332Cannabinoids in Parkinson's Disease
Q27336419Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics
Q92583461Complementary Therapies for Parkinson's Disease: What's Promoted, Rationale, Potential Risks and Benefits
Q41761143Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?
Q38811387Drug-Induced Dyskinesia, Part 1: Treatment of Levodopa-Induced Dyskinesia
Q50043450Exacerbation of psychosis triggered by a synthetic cannabinoid in a 70-year-old woman with Parkinson disease
Q64299310Marijuana for Parkinson's Disease?
Q40458313Media hype: Patient and scientific perspectives on misleading medical news.
Q59477201Medical treatment of dystonia
Q92298782Nabilone for non-motor symptoms of Parkinson's disease: a randomized placebo-controlled, double-blind, parallel-group, enriched enrolment randomized withdrawal study (The NMS-Nab Study)
Q26766090Recent Advances in Understanding and Managing Tourette Syndrome
Q30373216Self-reported efficacy of cannabis and other complementary medicine modalities by Parkinson's disease patients in colorado.
Q42495608The bright side of psychoactive substances: cannabinoid-based drugs in motor diseases.
Q38423817The role of cannabinoids and leptin in neurological diseases
Q34491345Therapeutic Developments for Tics and Myoclonus
Q47977953Treatment options for chorea

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