Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.

scientific article

Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/SYN.10054
P698PubMed publication ID11842443

P50authorIsabel Lastres-BeckerQ73043002
P2093author name stringFernando Berrendero
Javier Fernández-Ruiz
Jorge Manzanares
Henrik H Hansen
José A Ramos
Alberto Pérez-Rosado
Rosario De Miguel
P2860cites workThe endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)Q28343961
Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulataQ28377147
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents.Q52060269
Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function.Q54001516
The anandamide transport inhibitor AM404 activates vanilloid receptors.Q31384563
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and developmentQ31522100
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Fetal tissue transplants in animal models of Huntington's disease: the effects on damaged neuronal circuitry and behavioral deficitsQ33869424
Functional role of high-affinity anandamide transport, as revealed by selective inhibitionQ34436019
Brain cannabinoid systems as targets for the therapy of neurological disordersQ34492167
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and humanQ35120095
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrainQ37413174
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistryQ38331458
Aging, energy, and oxidative stress in neurodegenerative diseases.Q40478731
The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake.Q42450193
Adjuncts to dopamine replacement: a pragmatic approach to reducing the problem of dyskinesia in Parkinson's diseaseQ42464432
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamenQ42487505
Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease miceQ42490465
The cannabinoid receptor agonist WIN 55,212-2 reduces D2, but not D1, dopamine receptor-mediated alleviation of akinesia in the reserpine-treated rat model of Parkinson's diseaseQ42546097
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's diseaseQ43669613
Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia.Q44330257
Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.Q45289172
Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.Q45290294
Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acidQ45294402
Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid modelQ45295346
Differential responses of extracellular GABA to intrastriatal perfusions of 3-nitropropionic acid and quinolinic acid in the rat.Q45295617
Advances in Huntington's disease: implications for experimental therapeuticsQ45296397
Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's diseaseQ45296895
Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutationQ45297581
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's diseaseQ45300428
Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studiesQ45300432
Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: Studies in postmortem tissues and in rats with kainic acid lesionsQ45304178
Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult ratsQ45307246
Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404.Q46163967
Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleusQ47963301
Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamideQ48136699
Neuron-specific enolase (NSE) and non-neuronal enolase (NNE) mRNAs are co-expressed in neurons of the rat cerebellum: in situ hybridization histochemistryQ48255621
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituentQ48332786
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.Q48365871
Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicingQ48384593
3-Nitropropionic acid's lethal triplet: cooperative pathways of neurodegeneration.Q48403701
Cannabinoid effects in basal ganglia in a rat model of Parkinson's diseaseQ48435185
Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonistQ48484213
Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male ratsQ48500490
Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus.Q48962147
Modulation of GABAergic transmission in the globus pallidus by the synthetic cannabinoid WIN 55,212-2.Q49018761
P433issue1
P921main subjectHuntington's diseaseQ190564
endocannabinoidsQ10483908
P304page(s)23-35
P577publication date2002-04-01
P1433published inSynapseQ7662025
P1476titleAlleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease
P478volume44

Reverse relations

cites work (P2860)
Q34011553A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity
Q40654914AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide
Q34320147Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.
Q24793780Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate
Q35166600Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases
Q34200288Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission
Q55387906Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
Q37734568Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders.
Q36155898Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
Q36157657Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?
Q36977766Cannabinoids and neuroprotection in basal ganglia disorders.
Q40701861Cannabinoids for the Treatment of Movement Disorders.
Q44443061Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors
Q36779439Drugs of abuse and the aging brain
Q46667879Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity.
Q48428879Effects of endocannabinoid neurotransmission modulators on brain stimulation reward
Q39368845Endocannabinoid system in neurodegenerative disorders.
Q30391852Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration
Q89170794Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease
Q73304376Loss of cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease
Q37512670Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy.
Q92535276Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
Q41969953Neuroprotective effect of WIN55,212-2 against 3-nitropropionic acid-induced toxicity in the rat brain: involvement of CB1 and NMDA receptors
Q45303268Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease.
Q24644993Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter
Q44186888Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease
Q37872326Prospects for cannabinoid therapies in basal ganglia disorders
Q34746354Regulation of neurite outgrowth by G(i/o) signaling pathways
Q30434994TRPV1: A Potential Drug Target for Treating Various Diseases
Q36508056Tardive dyskinesia and essential fatty acids
Q37394164The endocannabinoid system as a target for the treatment of motor dysfunction
Q34098196The endocannabinoid system as a target for the treatment of neurodegenerative disease
Q34786832The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects.
Q35171113The therapeutic potential of cannabinoids for movement disorders
Q34212503The therapeutic potential of cannabis
Q36341688The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
Q37402927The therapeutic potential of novel cannabinoid receptors
Q34974856The therapeutic potential of the cannabinoids in neuroprotection
Q42948746Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism