Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders.

scientific article published on 12 April 2010

Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/J.1755-5949.2010.00144.X
P932PMC publication ID6493786
P698PubMed publication ID20406253
P5875ResearchGate publication ID43226206

P50authorMari Luz HernándezQ68297042
P2093author name stringJavier Fernández-Ruiz
José A Ramos
P2860cites workThe cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressiveQ73180328
Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout miceQ73264277
Association between cannabinoid receptor gene (CNR1) and childhood attention deficit/hyperactivity disorder in Spanish male alcoholic patientsQ73531406
Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeysQ80609691
Cannabinoid CB1 receptors are early downregulated followed by a further upregulation in the basal ganglia of mice with deletion of specific park genesQ84093381
Dopamine and reward: The anhedonia hypothesis 30 years onQ22252806
Cannabinoids in health and diseaseQ24633884
Gene-environment interplay between cannabis and psychosisQ24643510
Endocannabinoids in the retina: from marijuana to neuroprotectionQ24656049
Looking for the role of cannabinoid receptor heteromers in striatal functionQ24658338
Marijuana and cannabinoid regulation of brain reward circuitsQ24671514
Endocannabinoid signalling in the blood of patients with schizophreniaQ24800061
Role of endogenous cannabinoids in synaptic signalingQ28185075
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophreniaQ28206825
Dopamine and the regulation of cognition and attentionQ28215209
Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1Q28216128
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptorsQ28244889
Antioxidant and neuroprotective properties of N-arachidonoyldopamineQ28260510
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysisQ28268078
Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neuronsQ28272251
Cannabis and schizophrenia: towards a cannabinoid hypothesis of schizophreniaQ28285577
Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addictionQ28363073
Cannabinoid CB(1) receptors colocalize with tyrosine hydroxylase in cultured fetal mesencephalic neurons and their activation increases the levels of this enzymeQ28372132
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyQ29615905
Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens.Q31813503
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuseQ31863511
Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbensQ31877443
Dopaminergic regulation of cannabinoid receptor mRNA levels in the rat caudate-putamen: an in situ hybridization studyQ72656516
Tetrahydrocannabinol potentiates reserpine-induced hypokinesiaQ72916142
Elevated endogenous cannabinoids in schizophreniaQ73029596
Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brainsQ37264478
The endocannabinoid system in Huntington's disease.Q37264872
Endocannabinoid-mediated control of synaptic transmissionQ37363621
The basal ganglia in Parkinson's disease: current concepts and unexplained observationsQ37363923
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Q37371387
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamineQ37376434
Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammationQ37382150
The endocannabinoid system as a target for the treatment of motor dysfunctionQ37394164
Endocannabinoids and reproductive endocrinology.Q37428969
Basic neuroanatomy and neuropharmacology of cannabinoidsQ37444802
Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disordersQ37444808
Cannabinoids and appetite: food craving and food pleasureQ37444818
Cannabinoids and Parkinson's disease.Q37617450
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistryQ38331458
The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neuronsQ40069031
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's diseaseQ40358139
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.Q40799260
Marijuana for parkinsonian tremorQ41369366
Cannabis and neuroleptic agents in schizophreniaQ41535630
Dopamine activation of endogenous cannabinoid signaling in dorsal striatumQ41646203
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological studyQ42492989
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.Q42517324
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.Q42520647
Chronic (-)-delta9-tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in ratsQ42536101
Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.Q42624110
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's diseaseQ42695373
Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned ratsQ43425029
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioidsQ43517979
Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use.Q43581230
Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum.Q43621342
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.Q43683165
Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulationQ43698135
Cannabis induced dopamine release: an in-vivo SPECT studyQ43744306
A cannabinoid mechanism in relapse to cocaine seeking.Q43759232
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot studyQ43820144
Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain.Q43873792
Chronic exposure to morphine, cocaine or ethanol in rats produced different effects in brain cannabinoid CB(1) receptor binding and mRNA levelsQ43890403
Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring ratsQ44014660
Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoidsQ44051647
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.Q44102387
Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis studyQ44182591
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.Q44182704
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaineQ44189376
SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in ratsQ44190296
Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbensQ44299680
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanismQ44346123
Differential cannabinoid-induced electrophysiological effects in rat ventral tegmentumQ44385248
Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in ratsQ44386037
Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats.Q44413284
Effects of SR141716A on ethanol and sucrose self-administrationQ32117915
Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain.Q33186390
The role of the endogenous cannabinoid system in drug addictionQ33344540
Motor actions of cannabinoids in the basal ganglia output nucleiQ33720160
The endogenous cannabinoid system and brain developmentQ33815201
Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophreniaQ33932087
Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trialQ33958602
Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.Q33965686
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drugQ33995048
A missense mutation in human fatty acid amide hydrolase associated with problem drug use.Q34032872
Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystoniaQ34113369
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism.Q34181090
Cannabis and the brainQ34199483
Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerolQ34254854
Cannabinoids reduce symptoms of Tourette’s syndromeQ34266671
Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptomsQ34349067
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover studyQ34358022
Modulation of transmitter release via presynaptic cannabinoid receptorsQ34430714
Novel physiologic functions of endocannabinoids as revealed through the use of mutant miceQ34431882
Involvement of the endocannabinoid system in drug addictionQ34495242
Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological studyQ34524477
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.Q34605939
Endocannabinoids and immune regulationQ34607419
Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depressionQ34609936
The endocannabinoid system and painQ34612917
Levodopa-induced dyskinesiasQ34618170
Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview.Q34673177
The role of endocannabinoids in the hypothalamic regulation of visceral functionQ34673192
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
Mesolimbic dopaminergic decline after cannabinoid withdrawalQ34750833
What is the mechanism whereby cannabis use increases risk of psychosis?Q34900815
Can recreational doses of THC produce significant dopamine release in the human striatum?Q34987781
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actionsQ35045001
CB1 cannabinoid receptor signalling in Parkinson's diseaseQ35054346
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and humanQ35120095
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptorsQ35202878
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disordersQ35586641
Endocannabinoid signaling and long-term synaptic plasticity.Q35679432
Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence.Q35938826
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction.Q36119168
Cannabinoid tolerance and dependence: a review of studies in laboratory animalsQ36140875
CB1 receptor antagonists for the treatment of nicotine addictionQ36151299
Endocannabinoid signaling system and brain reward: emphasis on dopamineQ36152336
Dopaminergic neurones: much more than dopamine?Q36198137
The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?Q36228755
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.Q36248857
Expanding treatment of tobacco dependenceQ36282260
Endocannabinoids and the haematological systemQ36358723
Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disordersQ36425951
Cannabinoids and prefrontal cortical function: insights from preclinical studiesQ36436004
Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice.Q36441179
Cannabinoid control of motor function at the basal ganglia.Q36441208
The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addictionQ36478275
Endocannabinoids and the control of energy balanceQ36671574
Cannabis use and the risk of developing a psychotic disorderQ36713971
The endocannabinoid system in brain reward processesQ36741861
Biochemistry and pharmacology of endovanilloidsQ36756199
Cannabinoids and psychosisQ36756388
Cannabis use and psychiatric and cogitive disorders: the chicken or the egg?Q36784126
The endocannabinoid system and gut-brain signalling.Q36955435
The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidenceQ36977773
Presynaptic modulation by endocannabinoidsQ37026723
Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout miceQ37060812
Neurobiological mechanisms of cannabinoid addiction.Q37121224
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signalingQ37130639
Targeting the endocannabinoid system: to enhance or reduce?Q37150745
Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyondQ37164807
Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonismQ44418544
Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid ReceptorsQ44418969
Cannabinoid mechanism in reinstatement of heroin-seeking after a long period of abstinence in ratsQ44444449
Neuromorphological background of cannabis addictionQ44494962
Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent ratsQ44506503
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesiasQ44597458
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors.Q44723162
Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophreniaQ44748286
Effects of anandamide and morphine combinations on memory consolidation in cd1 mice: involvement of dopaminergic mechanisms.Q44780307
Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorderQ44915184
Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseQ44931450
Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuseQ45004332
Delta9-tetrahydrocannabinol improves motor control in a patient with musician's dystoniaQ45010982
Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptomsQ45049153
Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonismQ45310537
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.Q45932602
Effects of cannabinoids infused into the dorsal hippocampus upon memory formation in 3-days apomorphine-treated rats.Q46007120
Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens.Q46018366
Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.Q46023513
The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease.Q46026291
CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptorsQ46179251
Cannabinoid agonists stimulate [3H]GABA release in the globus pallidus of the rat when G(i) protein-receptor coupling is restricted: role of dopamine D2 receptorsQ46184685
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.Q46187005
Cannabinoid receptors in the bed nucleus of the stria terminalis control cortical excitation of midbrain dopamine cells in vivoQ46314846
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.Q46384445
Delta 9-tetrahydrocannabinol induces dopamine release in the human striatumQ46406572
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients.Q46456086
Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trialQ46595361
CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in ratsQ46677665
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implicationsQ46731448
The cannabinoid antagonist AM251 attenuates nicotine self-administration and nicotine-seeking behaviour in ratsQ46870466
Immunolocalization of CB1 receptor in rat striatal neurons: a confocal microscopy study.Q47242856
Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitroQ48127886
Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinolQ48141521
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.Q48217036
Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat.Q48254078
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological functionQ48262881
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.Q48273440
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent propertiesQ48324018
Repeated exposure to delta 9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat.Q48364989
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoidsQ48383234
Feasibility of central cannabinoid CB1 receptor imaging with [124I]AM281 PET demonstrated in a schizophrenic patientQ48443035
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.Q48445359
Increased cannabinoid receptor density in the posterior cingulate cortex in schizophreniaQ48532654
Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine releaseQ48656612
(AAT)n repeat in the cannabinoid receptor gene, CNR1: association with schizophrenia in a Spanish population.Q51915805
Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor antagonistsQ71293074
P433issue3
P921main subjectdopamineQ170304
cannabinoidsQ422936
pathophysiologyQ1135939
P304page(s)e72-91
P577publication date2010-04-12
P1433published inCNS Neuroscience & TherapeuticsQ5013184
P1476titleCannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders
P478volume16