In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability

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In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.PROSTAGLANDINS.2009.05.004
P932PMC publication ID2844932
P698PubMed publication ID19523530
P5875ResearchGate publication ID26289332

P2093author name stringAndrea Giuffrida
Lance R McMahon
P2860cites workIdentification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brainQ22001491
Cannabis and psychiatric disorders: it is not only addictionQ22242611
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gammaQ24314755
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alphaQ24319974
The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptorsQ24534526
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolaseQ24555807
Cannabinoid receptor localization in brainQ24558751
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effectsQ24569799
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipaseQ24569817
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptorsQ24642509
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentQ24653442
The orphan receptor GPR55 is a novel cannabinoid receptorQ24670137
Anandamide and vanilloid TRPV1 receptorsQ24672354
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurinQ24676808
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoidsQ24680497
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effectsQ24681369
Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanismQ24681426
Novel cannabinoid receptorsQ24681482
Evidence against the presence of an anandamide transporterQ24683153
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Role of endogenous cannabinoids in synaptic signalingQ28185075
Molecular characterization of a phospholipase D generating anandamide and its congenersQ28186509
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoidQ28204739
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivityQ28241306
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stabilityQ28244400
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neuronsQ28245016
Endocannabinoids in appetite control and the treatment of obesityQ28247257
A second endogenous cannabinoid that modulates long-term potentiationQ28248073
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonistQ28262546
Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptorsQ28265832
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampusQ28268567
Identification and functional characterization of brainstem cannabinoid CB2 receptorsQ28276972
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic painQ28281433
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amidesQ28295481
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neuronsQ28363375
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideQ28370516
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)Q28376536
Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neuronsQ28573124
Molecular composition of the endocannabinoid system at glutamatergic synapses.Q35220762
Δ9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxicationQ35226616
Cannabinoid receptors and endocannabinoids: evidence for new players.Q35594830
The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits.Q35626716
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J miceQ36095300
Self-administration of cannabinoids by experimental animals and human marijuana smokersQ36149174
Enhancement of endocannabinoid signaling and the pharmacotherapy of depression.Q36184363
The endocannabinoid system: a drug discovery perspective.Q36207547
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.Q36248857
Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders.Q36251616
Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout miceQ36370445
Evaluation of fatty acid amides in the carrageenan-induced paw edema modelQ36384547
Combinatorial roles of nuclear receptors in inflammation and immunityQ36403404
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibitionQ36404693
Cannabinoids: a new group of agonists of PPARsQ36417528
Endocannabinoid mechanisms of pain modulationQ36711160
The endocannabinoid system in brain reward processesQ36741861
Biochemistry and pharmacology of endovanilloidsQ36756199
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activitiesQ36785696
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesicsQ36803312
PPARs in the brainQ36849598
Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decadeQ36902047
The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeysQ36926051
The endocannabinoid system: emotion, learning and addictionQ37142237
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in ratsQ37146387
The cannabinoid system in Parkinson's disease: multiple targets to motor effectsQ37146722
Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in ratsQ37224649
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primatesQ37239653
Endocannabinoid signaling in microglial cellsQ37250243
The role of the endocannabinoid system in Alzheimer's disease: facts and hypothesesQ37264865
Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesiaQ37345438
The endogenous cannabinoid system modulates nicotine reward and dependenceQ37353755
Targeting CB2 receptors and the endocannabinoid system for the treatment of painQ37371095
Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.Q44086465
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.Q44102387
Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neuronsQ44333682
Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.Q44376607
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesiaQ44383212
Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid ReceptorsQ44418969
Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeysQ44492000
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channelsQ44524443
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesiasQ44597458
Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.Q44702932
Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometryQ44733045
Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats.Q44885114
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesiaQ44902561
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivityQ44903331
Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in miceQ44923318
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionalityQ44926848
Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampusQ44927481
Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseQ44931450
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerolQ44991723
Discriminative stimulus effects of anandamide in ratsQ45084272
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in miceQ45087565
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activityQ45096581
The biodisposition and metabolism of anandamide in miceQ45105707
The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.Q45108422
Evaluation of cannabimimetic discriminative stimulus effects of anandamide and methylated fluoroanandamide in rhesus monkeysQ45108581
Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.Q45110083
Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A.Q45113533
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotineQ45122619
Delta9-THC reinstates beer- and sucrose-seeking behaviour in abstinent rats: comparison with midazolam, food deprivation and predator odour.Q45154640
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.Q45173372
Formation of B and T cell subsets require the cannabinoid receptor CB2.Q46059840
Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nucleiQ46368889
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
The contribution of cyclooxygenase-2 to endocannabinoid metabolism and actionQ34647348
Cannabinoid receptors and their ligandsQ34673022
Oxidative metabolism of endocannabinoidsQ34673106
Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activationQ34743557
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.Q34807695
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J miceQ34846838
Transient receptor potential channels: targeting pain at the sourceQ34912798
Distinct cannabinoid sensitive receptors regulate hippocampal excitation and inhibition.Q35035824
Cannabinoids and neuroinflammationQ35046205
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedureQ35103785
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and humanQ35120095
Principles of drug abuse liability assessment in laboratory animalsQ35132182
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptorsQ35202878
Cellular accumulation of anandamide: consensus and controversyQ35217244
A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disordersQ81422672
Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical studyQ81630893
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Q37371387
Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammationQ37382150
The endocannabinoid system as a target for the treatment of motor dysfunctionQ37394164
The therapeutic potential of novel cannabinoid receptorsQ37402927
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cellsQ37599138
Presynaptic specificity of endocannabinoid signaling in the hippocampusQ39750122
Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.Q39831177
mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis.Q39917016
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?Q39954666
Multiple pathways involved in the biosynthesis of anandamideQ40106992
Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloidsQ40146865
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cellsQ40158906
Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiationQ40403600
Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.Q40449973
A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide.Q40528853
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamidesQ40702429
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolismQ40817229
Role of cyclic AMP in the actions of cannabinoid receptorsQ41090638
Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2.Q41093128
Dopamine activation of endogenous cannabinoid signaling in dorsal striatumQ41646203
Cannabinoids decrease the K(+) M-current in hippocampal CA1 neurons.Q41713139
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathwayQ41791622
Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanismQ41940595
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines.Q41983546
A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonistQ42017075
The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneuronsQ42110966
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brainQ42451047
Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS.Q42454049
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamenQ42487505
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brainQ42493166
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatumQ42523780
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in ratsQ42633348
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's diseaseQ42695373
Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats.Q43334794
Interactions between the CB1 receptor agonist Delta 9-THC and the CB1 receptor antagonist SR-141716 in rats: open-field revisited.Q43355908
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptorQ43503403
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamideQ43608453
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.Q43683165
Unawareness of dyskinesias in Parkinson's and Huntington's diseasesQ43696853
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamideQ43703172
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus.Q43742950
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot studyQ43820144
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoidsQ43830097
Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids.Q43833741
Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain.Q43873792
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP ratsQ43893862
15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonistQ43961283
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumQ43971441
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivoQ44028862
The endogenous cannabinoid system controls extinction of aversive memoriesQ44085607
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1Q28581167
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellumQ28587112
Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinolQ28833498
Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitroQ29144178
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Animal models of neurological deficits: how relevant is the rat?Q31091605
Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brainQ31570267
Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.Q31711251
CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatumQ31817073
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?Q33211909
Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors.Q33845285
Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus.Q33895436
Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerolQ33902321
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptorsQ33940288
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapsesQ33940688
Biology of endocannabinoid synthesis systemQ34015534
Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neuronsQ34023746
Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively?Q34098970
The validity of the reinstatement model of craving and relapse to drug use.Q34190646
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisQ34234907
Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type miceQ34289368
The role of glial cells in Parkinson's diseaseQ34318207
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.Q34320147
TRP ion channels in the nervous system.Q34326647
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover studyQ34358022
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.Q34397288
Evidence for novel cannabinoid receptorsQ34415409
An endocannabinoid mechanism for stress-induced analgesia.Q34428429
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogsQ34520933
A second fatty acid amide hydrolase with variable distribution among placental mammalsQ34570802
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alphaQ34571255
Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolaseQ34573261
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in ratsQ46471752
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's diseaseQ46491157
Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.Q46610682
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.Q46619350
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implicationsQ46731448
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid typQ46801175
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in ratsQ46819535
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.Q46852210
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout miceQ46920805
Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanolQ46943485
PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neuronsQ46949449
Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidanceQ47893448
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout miceQ47994629
Cannabinoid receptors and immunityQ48029970
Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in cultureQ48088888
Cannabinoid penetration into mouse brain as determined by ex vivo bindingQ48151733
Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids.Q48162553
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.Q48217036
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient miceQ48298650
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transportQ48315882
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituentQ48332786
Effects of endocannabinoid neurotransmission modulators on brain stimulation rewardQ48428879
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in ratsQ48485540
Comparative behavioral effects of CNS cholinesterase inhibitorsQ48510079
Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor.Q48556515
Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum.Q48631827
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.Q48658239
Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids.Q48764465
Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-oneQ48795983
Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemiaQ48882619
Rat brain cannabinoid receptor modulates N-type Ca2+ channels in a neuronal expression systemQ49047040
Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signalQ49124925
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.Q51375099
Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study.Q51976878
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.Q52030475
Cannabinoid receptors and reward in the rat: a conditioned place preference study.Q52165794
The CB(1) cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain.Q52537508
Evolutionary origins of the endocannabinoid systemQ56899189
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated ratsQ60690596
Anandamide – the other side of the coinQ60690621
Peroxisome Proliferator-Activated Receptor α Protects against Obesity-Induced Hepatic InflammationQ63363422
Chronic L-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned ratsQ64814751
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brainQ71988975
Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonistQ72422733
Are cannabinoids endogenous ligands for the VR1 capsaicin receptor?Q73423096
Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitorQ73704501
SR 141716A, a CB1 cannabinoid receptor antagonist, potentiates the locomotor stimulant effects of amphetamine and apomorphineQ73711457
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonistQ77766471
Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeysQ80609691
P433issue3-4
P407language of work or nameEnglishQ1860
P921main subjectendocannabinoidsQ10483908
Parkinson's diseaseQ11085
P304page(s)90-103
P577publication date2009-06-10
P1433published inProstaglandins and Other Lipid MediatorsQ15754476
P1476titleIn vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability
P478volume91

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cites work (P2860)
Q90582684A case series of the dynamics of lipid mediators in patients with sepsis
Q34292608Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats
Q36393644Cannabinoids and value-based decision making: implications for neurodegenerative disorders.
Q37625769Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats
Q35499568Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection
Q64254283Structural Insights into CB1 Receptor Biased Signaling
Q35119940Tolerance and cross-tolerance to cannabinoids in mice: schedule-controlled responding and hypothermia.

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