Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection

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Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection is …
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P6179Dimensions Publication ID1029602734
P356DOI10.1186/S13024-015-0012-0
P932PMC publication ID4404240
P698PubMed publication ID25888232
P5875ResearchGate publication ID275101898

P50authorDong-Kug ChoiQ61120429
P2093author name stringSandeep Vasant More
P2860cites workIdentification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brainQ22001491
A review of Parkinson's diseaseQ22242927
Mechanisms for selection of basic motor programs – roles for the striatum and pallidumQ22337301
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Autophagy, mitochondria and oxidative stress: cross-talk and redox signallingQ24608960
Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilitiesQ24623282
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentQ24653442
Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growthQ24656080
Looking for the role of cannabinoid receptor heteromers in striatal functionQ24658338
The orphan receptor GPR55 is a novel cannabinoid receptorQ24670137
Anandamide and vanilloid TRPV1 receptorsQ24672354
Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptorQ24672600
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurinQ24676808
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cellsQ24678857
Novel cannabinoid receptorsQ24681482
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidantsQ24685540
Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's diseaseQ26849232
Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNSQ26853436
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brainsQ28189423
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
CB1 cannabinoid receptors and on-demand defense against excitotoxicityQ28207143
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathwayQ28215554
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategiesQ28241318
Identification of GPR55 as a lysophosphatidylinositol receptorQ28244299
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptorsQ28244889
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neuronsQ28245016
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanismQ28252850
Functional neuroanatomy of the endocannabinoid systemQ28254682
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysisQ28268078
Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical studyQ28273200
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampusQ28286042
Adenosine-cannabinoid receptor interactions. Implications for striatal functionQ28286488
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂Q28298445
Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brainQ46807435
Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndromeQ46859134
Strain differences in the expression of endocannabinoid genes and in cannabinoid receptor binding in the brain of Lewis and Fischer 344 rats.Q46922174
Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias.Q46943000
Immunolocalization of CB1 receptor in rat striatal neurons: a confocal microscopy study.Q47242856
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout miceQ47994629
Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway.Q48028956
Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptorsQ48087305
The endocannabinoid system in rat gliosomes and its role in the modulation of glutamate release.Q48089129
Anandamide activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamusQ48126877
The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesisQ48143381
Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidenceQ48148192
Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian ratsQ48192232
Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of NeurologyQ34417710
Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigraQ34421920
Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectivesQ34426072
Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.Q34440282
Cannabinoids in experimental stroke: a systematic review and meta-analysis.Q34452972
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned ratsQ34482483
Brain cannabinoid systems as targets for the therapy of neurological disordersQ34492167
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.Q34504178
Cannabinoids and neuroprotectionQ34520143
AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosisQ34539350
Cannabinoids: potential anticancer agentsQ34542671
Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferationQ34570786
Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cellsQ34571086
Circuits and circuit disorders of the basal gangliaQ34599488
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatumQ34605794
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's diseaseQ34627188
Oxidative metabolism of endocannabinoidsQ34673106
Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cellsQ34700334
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects.Q34786832
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cellsQ34929688
Acute neuronal injury, excitotoxicity, and the endocannabinoid systemQ34995079
Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease.Q35008120
Temporal changes of CB1 cannabinoid receptor in the basal ganglia as a possible structure-specific plasticity process in 6-OHDA lesioned rats.Q35014951
CB1 cannabinoid receptor signalling in Parkinson's diseaseQ35054346
Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNSQ35107820
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and humanQ35120095
Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's diseaseQ35193305
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress responseQ35229784
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disordersQ35586641
The basal ganglia and motor controlQ35593766
CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signalingQ35668816
The cannabinoid agonist WIN55212-2 decreases L-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated ratsQ35740152
Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptorsQ35807657
CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental RegulationQ35820005
Endocannabinoid-dopamine interactions in striatal synaptic plasticityQ35898412
Update on the role of cannabinoid receptors after ischemic strokeQ35915645
Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression.Q36132823
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cellsQ36176444
α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.Q36234694
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.Q36248857
Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expressionQ36358055
Effects on cell viability.Q36441223
Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area.Q36452302
Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.Q36612284
Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.Q36641684
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?Q36671508
Endocannabinoid system: potential novel targets for treatment of schizophreniaQ36675661
Drug discovery in Parkinson's disease-Update and developments in the use of cellular modelsQ36680414
Immune control by endocannabinoids - new mechanisms of neuroprotection?Q36695436
The emerging functions of endocannabinoid signaling during CNS development.Q36707633
The endocannabinoid system in targeting inflammatory neurodegenerative diseasesQ36756837
Dopamine-mediated regulation of corticostriatal synaptic plasticity.Q36762821
The endocannabinoid system and neurogenesis in health and disease.Q36778571
Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat.Q36861976
Endocannabinoids in basal ganglia circuits: implications for Parkinson diseaseQ36884599
Role of cannabinoids and endocannabinoids in cerebral ischemiaQ36967863
Cannabinoids and neuroprotection in basal ganglia disorders.Q36977766
Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats.Q36990238
Cannabinoids and neuroprotection in motor-related disordersQ37066184
Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion modelQ37087780
Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activityQ37140712
The cannabinoid system in Parkinson's disease: multiple targets to motor effectsQ37146722
Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell deathQ37192723
Neurotrophic factors and structural plasticity in addictionQ37223964
Endocannabinoid signaling in microglial cellsQ37250243
Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.Q37253331
The endocannabinoid system in Parkinson's diseaseQ37264881
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Q37371387
Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevanceQ37379456
NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian miceQ37393199
The endocannabinoid system as a target for the treatment of motor dysfunctionQ37394164
Cannabinoid system in neurodegeneration: new perspectives in Alzheimer's diseaseQ37489960
The cannabinoid CB₂ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesisQ37522883
Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNSQ37531460
Signal transduction of the CB1 cannabinoid receptorQ37557059
Cannabinoids and Parkinson's disease.Q37617450
Changes in CB(1) and CB(2) receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxiasQ37637769
Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunitiesQ37703507
The endocannabinoid system as a target for the treatment of neuronal damageQ37709370
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomasQ37752096
The Multiplicity of Action of Cannabinoids: Implications for Treating NeurodegenerationQ37793366
Homeostatic changes of the endocannabinoid system in Parkinson's diseaseQ37853933
Prospects for cannabinoid therapies in basal ganglia disordersQ37872326
Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's diseaseQ37893672
Phytocannabinoids as novel therapeutic agents in CNS disorders.Q37933589
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?Q38012845
The role of bioactive compounds on the promotion of neurite outgrowth.Q38016042
TRPV1: a stress response protein in the central nervous system.Q38022033
Adult neurogenesis in Parkinson's diseaseQ38024276
The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effectsQ38072364
The influence of cannabinoids on generic traits of neurodegenerationQ38156518
Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signallingQ38164390
Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventionsQ38207680
Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrierQ38220272
Direct and indirect pathways of basal ganglia: a critical reappraisalQ38234309
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progressionQ38268886
Rising stars: modulation of brain functions by astroglial type-1 cannabinoid receptorsQ38276026
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent mannerQ38289958
A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicityQ34011553
Levodopa motor complications in Parkinson's diseaseQ34070854
Quantification of brain endocannabinoid levels: methods, interpretations and pitfallsQ34098167
Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.Q34098292
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposureQ34118397
Endocannabinoid signaling in the brainQ34125520
Nonpsychotropic cannabinoid receptors regulate microglial cell migration.Q34179008
CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?Q34186015
Cannabinoid-1 receptor gene deletion has a compartment-specific affect on the dendritic and axonal availability of μ-opioid receptors and on dopamine axons in the mouse nucleus accumbensQ34197458
Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic culturesQ34273763
Autophagy of mitochondria: a promising therapeutic target for neurodegenerative diseaseQ34287719
Anandamide: some like it hot.Q34296080
Endocannabinoid signaling and synaptic functionQ34304094
Pathophysiology of levodopa-induced dyskinesia: potential for new therapiesQ34325365
Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptomsQ34349067
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover studyQ34358022
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neuronsQ34380089
Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational studyQ34409345
Evidence for novel cannabinoid receptorsQ34415409
Pharmacological treatment of Parkinson disease: a reviewQ34416640
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistryQ38331458
A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells.Q38927583
Cannabinoid receptors CB1 and CB2 form functional heteromers in brainQ39359086
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharideQ39467487
Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia.Q39801798
MK-801 inhibits L-DOPA-induced abnormal involuntary movements only at doses that worsen parkinsonismQ39906818
Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvementQ40313822
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's diseaseQ40358139
The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B).Q40513443
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.Q40799260
Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in ratsQ40877659
Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoidsQ41129946
Regulation of a neuronal form of focal adhesion kinase by anandamideQ41166826
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.Q41292913
Marijuana for parkinsonian tremorQ41369366
Dopamine activation of endogenous cannabinoid signaling in dorsal striatumQ41646203
Serum brain-derived neurotrophic factor levels in different neurological diseases.Q41811172
Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunctionQ41968489
Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonismQ42095959
The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamideQ42108464
Endocannabinoids in nervous system health and disease: the big picture in a nutshellQ42112685
Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patientsQ42167232
Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compactaQ42450917
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brainQ42451047
Cannabinoid (CB(1)), GABA(A) and GABA(B) receptor subunit changes in the globus pallidus in Huntington's disease.Q42454539
Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's diseaseQ42455405
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.Q42463589
Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularisQ42471782
Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.Q42477740
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brainQ42493166
Bidirectional plasticity in striatonigral synapses: a switch to balance direct and indirect basal ganglia pathwaysQ42497714
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.Q42500348
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
CB2 cannabinoid receptors promote mouse neural stem cell proliferation.Q42508956
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.Q42520647
Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neuronsQ42523185
The cannabinoid receptor agonist WIN 55,212-2 reduces D2, but not D1, dopamine receptor-mediated alleviation of akinesia in the reserpine-treated rat model of Parkinson's diseaseQ42546097
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat.Q42553964
Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in ratsQ42585836
Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.Q42624110
Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias.Q42747563
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned ratsQ42871461
Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.Q42872711
Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture.Q43012779
Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependenceQ43061541
Molecular profiling of a 6-hydroxydopamine model of Parkinson's diseaseQ43156838
Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapsesQ43191478
BDNF regulates neuronal sensitivity to endocannabinoidsQ43264175
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.Q43266820
Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 miceQ43280499
Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned ratsQ43425029
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociceptionQ43511723
Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum.Q43621342
Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal culturesQ48246173
A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression.Q48257417
Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis.Q48257647
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological functionQ48262881
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent propertiesQ48324018
Anandamide hydrolysis by human cells in culture and brainQ48346766
Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brainQ48360198
Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicityQ48398761
Cannabinoid CB1 receptors activation and coactivation with D2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetryQ48407695
Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's diseaseQ48427629
Cannabinoid effects in basal ganglia in a rat model of Parkinson's diseaseQ48435185
Activation of the CB2 receptor system reverses amyloid-induced memory deficiencyQ48440561
Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesisQ48475163
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in ratsQ48485540
Mitochondrial CB₁ receptors regulate neuronal energy metabolismQ48629492
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid toleranceQ48720514
Ultrastructural localization of neuronal brain CB2 cannabinoid receptors.Q48837860
CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicityQ48914137
Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson´s diseaseQ48923652
5-HT(1A) receptor stimulation and L-DOPA-induced dyskinesia in Parkinson's disease: bridging the gap between serotonergic and glutamatergic mechanismsQ48961091
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.Q43683165
Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicityQ43713675
Exogenous anandamide protects rat brain against acute neuronal injury in vivo.Q43792413
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot studyQ43820144
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumQ43971441
CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice.Q44094824
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.Q44102387
Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's diseaseQ44237885
Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidaseQ44256125
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharideQ44267931
Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus.Q44334367
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanismQ44346123
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesiaQ44383212
Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid ReceptorsQ44418969
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised ratsQ44519071
Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's diseaseQ44570011
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesiasQ44597458
Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivoQ44641132
D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptorQ44666474
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.Q44770106
Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicityQ44840035
Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by Δ9-THC in the ratQ44895997
Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseQ44931450
Effects on turning of microinjections into basal ganglia of D(1) and D(2) dopamine receptors agonists and the cannabinoid CB(1) antagonist SR141716A in a rat Parkinson's modelQ44933218
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
Defective adult neurogenesis in CB1 cannabinoid receptor knockout miceQ44987543
The cannabinoid CB1 receptor biphasically modulates motor activity and regulates dopamine and glutamate release region dependentlyQ45174910
Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro.Q45230637
The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum.Q45302088
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats.Q45310403
Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonismQ45310537
Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress.Q46013028
Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.Q46023513
The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease.Q46026291
Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamideQ46087128
Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy.Q46123071
Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmissionQ46146049
Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.Q46179690
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.Q46279749
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.Q46384445
Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometryQ46407462
Lowered cAMP and cGMP signalling in the brain during levodopa-induced dyskinesias in hemiparkinsonian rats: new aspects in the pathogenetic mechanisms.Q46418668
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's diseaseQ46491157
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.Q46518412
Endocannabinoids mediate neuron-astrocyte communicationQ46682045
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout miceQ28343324
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)Q28343961
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cellsQ28369985
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideQ28370516
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cellsQ28378272
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvementQ28394506
Functional CB2 type cannabinoid receptors at CNS synapsesQ28575031
Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesisQ28575346
Pruning and loss of excitatory synapses by the parkin ubiquitin ligaseQ28576054
Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampusQ28579094
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathwayQ29306901
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyQ29615905
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neuronsQ29619181
Parkinson's disease. First of two partsQ29620416
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbensQ30499463
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbensQ30500199
RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficitsQ30504550
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice.Q30506148
Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity.Q30573949
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic miceQ30620210
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?Q33211909
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cordQ33235278
The role of excitotoxicity in neurodegenerative disease: implications for therapyQ33639170
Parkinson's disease: from molecular pathways in disease to therapeutic approachesQ33644302
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implicationsQ33714587
A restricted population of CB1 cannabinoid receptors with neuroprotective activityQ33730578
In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liabilityQ33751118
Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor.Q33765631
Cannabis in movement disordersQ33812356
Pharmacological characterization of GPR55, a putative cannabinoid receptorQ33869340
Clinical pharmacology of levodopa-induced dyskinesia.Q33890292
Functional changes of the basal ganglia circuitry in Parkinson's disease.Q33924857
Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortexQ34001324
Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study.Q51976878
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents.Q52060269
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.Q52578470
Blockade of 45Ca2+ influx through the N-methyl-D-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211.Q55066045
Parkinson's diseaseQ56877819
Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamineQ58866555
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated ratsQ60690596
Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ9-Tetrahydrocannabinol-Tolerant RatsQ60690625
A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brainQ64212085
The cannabinoid agonists WIN 55,212-2 and CP 55,940 attenuate rotational behavior induced by a dopamine D1 but not a D2 agonist in rats with unilateral lesions of the nigrostriatal pathwayQ70973782
Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonistQ71583483
45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211Q71798445
The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neuronsQ72302141
Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrainQ73101567
Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligandQ74219879
Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeysQ80609691
Endocannabinoids and traumatic brain injuryQ81478373
Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical studyQ81630893
Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activationQ82486794
Long-term antidyskinetic efficacy of amantadine in Parkinson's diseaseQ83112596
Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moietyQ83486811
Maternal exposure to the CB1 cannabinoid agonist WIN 55212-2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspringQ85244258
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P921main subjectcannabinoidsQ422936
basal gangliaQ464210
nervous systemQ9404
hydrocarbonQ43648
Parkinson's diseaseQ11085
neuroprotective agentQ50377190
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)17
P577publication date2015-04-08
P1433published inMolecular NeurodegenerationQ15817329
P1476titlePromising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection
P478volume10

Reverse relations

cites work (P2860)
Q525878602-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Q42087548A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease
Q51539430An Information Theoretical Study of the Epistasis Between the CNR1 1359 G/A Polymorphism and the Taq1A and Taq1B DRD2 Polymorphisms: Assessing the Susceptibility to Cannabis Addiction in a Turkish Population.
Q64073287Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Q61449210Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages
Q90699673Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive Frailty
Q64811535Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease
Q52148259Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity.
Q47192906Do psychoactive drugs have a therapeutic role in compulsivity? Studies on schedule-induced polydipsia.
Q90191256Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder
Q28073686Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Q26778885Emerging drugs of abuse: current perspectives on synthetic cannabinoids
Q37512670Marijuana Compounds: A Nonconventional Approach to Parkinson's Disease Therapy.
Q92028537Metal Chelation Therapy and Parkinson's Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs
Q38832042Neuroprotective Effect Is Driven Through the Upregulation of CB1 Receptor in Experimental Autoimmune Encephalomyelitis
Q39421016Polyunsaturated fatty acids and endocannabinoids in health and disease.
Q41829602Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA).
Q38725907Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells.
Q64254283Structural Insights into CB1 Receptor Biased Signaling
Q99615888The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model
Q89771533The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention
Q55397242Therapeutic potential of medicinal marijuana: an educational primer for health care professionals.

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