Cannabinoid CB1 receptors activation and coactivation with D2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetry

scientific article published on 23 December 2014

Cannabinoid CB1 receptors activation and coactivation with D2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetry is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/SYN.21796
P698PubMed publication ID25522178

P2093author name stringI Daniel Limón
Benjamín Florán
Francisco Paz-Bermúdez
Brenda González-Hernández
Ana Báez-Cordero
Guadalupe Muñoz-Arenas
René Caballero-Florán
P2860cites workD2 receptor-mediated inhibition of GABA release by endogenous dopamine in the rat globus pallidusQ48581395
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Long-term changes of striatal dopamine D2 receptors in patients with Parkinson's disease: a study with positron emission tomography and [11C]racloprideQ48822647
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Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson´s diseaseQ48923652
Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus.Q48962147
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysisQ28268078
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Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the ratQ28580400
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Concurrent activation of striatal direct and indirect pathways during action initiation.Q30579307
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?Q33211909
The fetal hypothalamus has the potential to generate cells with a gonadotropin releasing hormone (GnRH) phenotypeQ33406270
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's diseaseQ33951094
Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathwayQ34133059
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Pathophysiology of parkinsonismQ34777496
Temporal changes of CB1 cannabinoid receptor in the basal ganglia as a possible structure-specific plasticity process in 6-OHDA lesioned rats.Q35014951
Role of Striatum in the Pause and Burst Generation in the Globus Pallidus of 6-OHDA-Treated RatsQ35039660
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors.Q36248857
Modulation of striatal projection systems by dopamineQ36367283
Past, present, and future of the pathophysiological model of the Basal GangliaQ37909948
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's diseaseQ40358139
Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo.Q41006239
The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake.Q42450193
Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamenQ42487505
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.Q42520647
Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methodsQ42524102
Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices.Q43170612
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's diseaseQ44237885
Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal gangliaQ44451116
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa‐induced dyskinesiasQ44597458
D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptorQ44666474
Effects on turning of microinjections into basal ganglia of D(1) and D(2) dopamine receptors agonists and the cannabinoid CB(1) antagonist SR141716A in a rat Parkinson's modelQ44933218
Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonismQ45310537
The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease.Q46026291
Cannabinoid agonists stimulate [3H]GABA release in the globus pallidus of the rat when G(i) protein-receptor coupling is restricted: role of dopamine D2 receptorsQ46184685
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.Q46384445
GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transportersQ46437070
6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.Q46511780
The CB1 cannabinoid receptor in the brain.Q48285234
Cannabinoid effects in basal ganglia in a rat model of Parkinson's diseaseQ48435185
P433issue3
P921main subjectCNR2Q17907844
cannabinoid receptorQ421237
cannabinoidsQ422936
P304page(s)103-114
P577publication date2014-12-23
P1433published inSynapseQ7662025
P1476titleCannabinoid CB1 receptors activation and coactivation with D2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetry
P478volume69

Reverse relations

cites work (P2860)
Q92295837GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum
Q35499568Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection
Q50422457The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra

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