Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons

scientific article published on March 2012

Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4129-11.2012
P932PMC publication ID6621208
P698PubMed publication ID22442066

P50authorLynn A RaymondQ39804644
P2093author name stringAnn Marie Craig
Liang Wang
Austen J Milnerwood
Marja D Sepers
Max Cynader
Kevin She
Hwan Lee
Alexandra M Kaufman
Ainsley Coquinco
P2860cites workDopaminergic Terminals in the Nucleus Accumbens But Not the Dorsal Striatum Corelease GlutamateQ22255504
Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapsesQ24619395
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
The glutamate receptor ion channelsQ28137916
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DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in strokeQ28505607
Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapsesQ28567505
Culturing hippocampal neuronsQ29615174
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disordersQ29617936
Function and regulation of CREB family transcription factors in the nervous systemQ29619559
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathwaysQ29619779
The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neuronesQ33256442
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic miceQ33597194
Organization of NMDA receptors at extrasynaptic locationsQ33733292
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease miceQ34098463
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disordersQ34138025
Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantineQ34389871
Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and functionQ34629359
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatumQ34841740
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtinQ35013054
The Yin and Yang of NMDA receptor signallingQ35048924
NMDA receptor surface mobility depends on NR2A-2B subunitsQ35214776
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington diseaseQ35595444
NMDA receptor function: subunit composition versus spatial distributionQ36544668
Synaptic NMDA receptor activity boosts intrinsic antioxidant defensesQ36916561
Glutamate transporters: confining runaway excitation by shaping synaptic transmissionQ36995107
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and functionQ37279404
Do astrocytes really exocytose neurotransmitters?Q37714299
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Suppression of the intrinsic apoptosis pathway by synaptic activity.Q39499029
Synaptically driven state transitions in distal dendrites of striatal spiny neuronsQ39733559
The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitroQ40955590
Ionic dependence of glutamate neurotoxicityQ41343328
Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.Q41712761
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptorsQ42738430
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.Q42792570
N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95.Q42910860
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal deathQ43187988
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligandQ43227890
Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signalingQ43235347
Subunit-specific NMDA receptor trafficking to synapsesQ44088078
Differential regulation of synaptic and extra-synaptic NMDA receptorsQ44114037
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactionsQ44193907
Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activityQ44489175
Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitroQ44746224
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticityQ44895962
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampusQ44897972
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.Q45050775
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington diseaseQ45298474
Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease.Q45300648
Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's diseaseQ45302405
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.Q45307199
Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activationQ46064244
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.Q46305019
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.Q46423618
Modulation of triheteromeric NMDA receptors by N-terminal domain ligandsQ46453271
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.Q46461035
Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor traffickingQ46517786
NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.Q46738255
Microfluidic culture platform for neuroscience researchQ46771334
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neuronsQ46828776
The role of the PDZ protein GIPC in regulating NMDA receptor traffickingQ46932821
Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.Q46935383
Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neuronsQ46973022
Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiationQ47715726
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptorsQ48135580
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivoQ48241774
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depressionQ48451127
Postnatal development of axosomatic synapses in the rat visual cortex: morphogenesis and quantitative evaluationQ48507804
The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons.Q49048418
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptorsQ49132765
Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices.Q53564093
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neuronsQ72216851
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectstriatumQ1319792
P304page(s)3992-4003
P577publication date2012-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleOpposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons
P478volume32

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