Milestones in research on the pathophysiology of Parkinson's disease

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Milestones in research on the pathophysiology of Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/MDS.23695
P932PMC publication ID4272856
P698PubMed publication ID21626548

P50authorMahlon DeLongQ15374218
P2093author name stringThomas Wichmann
Jose A Obeso
Jorge Guridi
P2860cites workSlow oscillatory activity and levodopa-induced dyskinesias in Parkinson's diseaseQ48548811
Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primateQ48810107
Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysisQ48898151
Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q49138365
Evidence in favor of Braak staging of Parkinson's disease.Q53409292
Dorsal subthalamotomy for Parkinson's disease.Q53896853
Restoration of thalamocortical activity after posteroventral pallidotomy in Parkinson's diseaseQ57089269
Degeneration of the centré median-parafascicular complex in Parkinson's diseaseQ59544666
Changes in the local cerebral metabolic rate for glucose in the MPTP primate model of Parkinson's diseaseQ68815933
Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with ageQ69262673
Bilateral subthalamic nucleus stimulation for severe Parkinson's diseaseQ70875241
Organization of nonprimary motor cortical inputs on pyramidal and nonpyramidal tract neurons of primary motor cortex: An electrophysiological study in the macaque monkeyQ73365202
Basal ganglia and cerebellar loops: motor and cognitive circuitsQ73553166
Equilibrium potential of GABA(A) current and implications for rebound burst firing in rat subthalamic neurons in vitroQ73776433
Electrophysiological and morphological characteristics of three subtypes of rat globus pallidus neurone in vitroQ74257952
Kinematic evaluation of gestural and repetitive single joint movements of the arm after posteroventral pallidotomy, subthalamotomy or both procedures combined in two Parkinson's disease patients: two case studiesQ80915129
Critical evaluation of the Braak staging scheme for Parkinson's diseaseQ84147549
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitryQ24630976
Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleusQ28241545
Chronic parkinsonism secondary to intravenous injection of meperidine analoguesQ28323857
Leksell's posteroventral pallidotomy in the treatment of Parkinson's diseaseQ28324320
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and CortexQ29391304
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
The functional anatomy of basal ganglia disordersQ29617461
Primate models of movement disorders of basal ganglia originQ29618489
Functional architecture of basal ganglia circuits: neural substrates of parallel processingQ29618729
Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease.Q31826825
Evidence of a breakdown of corticostriatal connections in Parkinson's disease.Q33214147
Consequences of unilateral nigrostriatal denervation on the thalamostriatal pathway in rats.Q33240647
Differential excitability and modulation of striatal medium spiny neuron dendritesQ33382961
Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trialQ33623861
High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremorQ33920933
Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson diseaseQ34049606
Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeysQ34061020
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviorsQ34093012
Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson's disease.Q34144961
Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal systemQ34248307
The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesiaQ34251567
Extrastriatal dopaminergic circuits of the Basal GangliaQ34330022
Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot studyQ34396153
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.Q34521936
Circuits and circuit disorders of the basal gangliaQ34599488
Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathwayQ34688620
Pathophysiology of parkinsonismQ34777496
Enhanced synchrony among primary motor cortex neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease.Q42521926
Neuronal synchronization of tonically active neurons in the striatum of normal and parkinsonian primatesQ42526111
Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's diseaseQ42830127
What can man do without basal ganglia motor output? The effect of combined unilateral subthalamotomy and pallidotomy in a patient with Parkinson's disease.Q43278477
Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 monthsQ43704582
Movement-related changes in synchronization in the human basal gangliaQ44002200
Neural mechanisms mediating 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced parkinsonism in the monkey: relative contributions of the striatopallidal and striatonigral pathways as suggested by 2-deoxyglucose uptakeQ44196091
Excitotoxic acid lesions of the primate subthalamic nucleus result in transient dyskinesias of the contralateral limbsQ44758741
Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkeyQ44987956
Bilateral subthalamotomy in Parkinson's disease: initial and long-term response.Q45249855
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlationsQ45302799
A neostriatal habit learning system in humans.Q45979314
Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.Q46586668
Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortexQ46617667
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models.Q46896175
Electrophysiology of globus pallidus neurons in vitroQ47924524
Motor subcircuits mediating the control of movement velocity: a PET studyQ48376274
Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway.Q48391594
Changes in the local cerebral metabolic rate for glucose in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of Parkinson's diseaseQ48427735
Bilateral dorsolateral subthalamotomy for advanced Parkinson's diseaseQ48435808
Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway.Q48454428
Common neural mechanisms in experimental chorea and hemiballismus in the monkey. Evidence from 2-deoxyglucose autoradiographyQ48469047
Subcortical changes in the regional uptake of [3H]-2-deoxyglucose in the brain of the monkey during experimental choreiform dyskinesia elicited by injection of a gamma-aminobutyric acid antagonist into the subthalamic nucleusQ48482417
Seven problems on the basal gangliaQ34903682
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).Q35045422
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's diseaseQ35072636
Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's diseaseQ35097464
Macro-architecture of basal ganglia loops with the cerebral cortex: use of rabies virus to reveal multisynaptic circuitsQ35599353
Dichotomous anatomical properties of adult striatal medium spiny neuronsQ35607269
Oscillations in the basal ganglia under normal conditions and in movement disordersQ36531778
Disinhibition as a basic process in the expression of striatal functionsQ36586037
Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiologyQ36610366
Basal ganglia oscillations and pathophysiology of movement disordersQ36644641
GABAergic control of the subthalamic nucleusQ36820596
Pathological synchronization in Parkinson's disease: networks, models and treatmentsQ36833065
Paradoxes of functional neurosurgery: clues from basal ganglia recordingsQ36999845
Abnormal oscillatory synchronisation in the motor system leads to impaired movement.Q37067771
Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeysQ37186952
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ37343442
A hypothesis on the pathophysiological mechanisms that underlie levodopa- or dopamine agonist-induced dyskinesia in Parkinson's disease: implications for future strategies in treatmentQ37585084
A timeline for Parkinson's diseaseQ37619101
Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-upQ39216879
Striatal inhomogeneities and basal ganglia functionQ39290893
Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkeyQ39523670
Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's diseaseQ39732881
Biochemical and pharmacological aspects of ParkinsonismQ39898079
Drug Therapy of ParkinsonismQ39915162
The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's diseaseQ40630408
Basal ganglia intrinsic circuits and their role in behaviorQ40722775
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.Q40817289
Excitotoxic acid lesions of the primate subthalamic nucleus result in reduced pallidal neuronal activity during active holdingQ41105661
Reversal of experimental parkinsonism by lesions of the subthalamic nucleusQ41241320
Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex. The site of drug action and a hypothesis for the neural mechanisms of choreaQ41400116
Basal ganglia pathophysiology. A critical review.Q41624512
Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primatesQ41701358
A critical evaluation of the Braak staging scheme for Parkinson's disease.Q42260364
Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonismQ42464540
Multiple Output Channels in the Basal GangliaQ42482773
Ratio of inhibited-to-activated pallidal neurons decreases dramatically during passive limb movement in the MPTP-treated monkeyQ42484815
Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonismQ42488325
Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkeyQ42490761
The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonismQ42493851
The primate subthalamic nucleus. III. Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonismQ42493857
Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism.Q42495652
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Late emergence of synchronized oscillatory activity in the pallidum during progressive Parkinsonism.Q42519040
Where does parkinson disease pathology begin in the brain?Q42521711
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
Parkinson's diseaseQ11085
P304page(s)1032-1041
P577publication date2011-05-01
P1433published inMovement DisordersQ1486418
P1476titleMilestones in research on the pathophysiology of Parkinson's disease
P478volume26

Reverse relations

cites work (P2860)
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