Molecular insights into cortico-striatal miscommunications in Huntington's disease

scientific article published on 7 November 2017

Molecular insights into cortico-striatal miscommunications in Huntington's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CONB.2017.10.019
P932PMC publication ID5825262
P698PubMed publication ID29125980

P2093author name stringX William Yang
Matthew B Veldman
P2860cites workHuntingtin interacting proteins are genetic modifiers of neurodegenerationQ21145230
The choreography of neuroinflammation in Huntington's diseaseQ26828403
Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytesQ27305777
Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's diseaseQ29144918
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathwayQ29306901
A general framework for weighted gene co-expression network analysisQ29617580
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's diseaseQ29994841
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesisQ30418699
Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptomsQ30441124
The mouse cortico-striatal projectomeQ30489469
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptomsQ30492587
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's diseaseQ30581321
Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD miceQ30588621
Huntington disease: natural history, biomarkers and prospects for therapeuticsQ30774172
A restricted population of CB1 cannabinoid receptors with neuroprotective activityQ33730578
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model miceQ33781761
New insights on the role of microglia in synaptic pruning in health and diseaseQ33821505
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factorsQ33959395
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease miceQ34098463
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disordersQ34138025
Network organization of the huntingtin proteomic interactome in mammalian brainQ34287971
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 miceQ34338809
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.Q34700142
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degenerationQ34706597
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtinQ35013054
Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice.Q45294943
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.Q45296827
Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's diseaseQ45299632
Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington's diseaseQ45301104
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.Q46306829
Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.Q48669214
Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's diseaseQ35164101
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicityQ35561965
Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's diseaseQ35828444
Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's diseaseQ35999314
Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's diseaseQ36206024
Systems biology and gene networks in neurodevelopmental and neurodegenerative disordersQ36424672
Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.Q36431970
Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouseQ36713909
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model MiceQ36718633
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD miceQ37072467
Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesisQ37165188
Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease miceQ37255018
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's diseaseQ37281403
Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouseQ37294750
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's diseaseQ37345118
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease modelsQ37607024
Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatumQ37680104
Huntington's disease: can mice lead the way to treatment?Q37840353
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Q37930190
Corticostriatal synaptic adaptations in Huntington's diseaseQ38362877
Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated DatasetsQ38726920
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.Q38746156
The Biology of Huntingtin.Q38759081
New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cellsQ38913463
Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.Q39168396
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.Q39333674
Reactive Astrocytes: Production, Function, and Therapeutic PotentialQ39388343
Disruption of Rab11 activity in a knock-in mouse model of Huntington's diseaseQ39809646
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's diseaseQ42098044
Genetically-directed Sparse Neuronal Labeling in BAC Transgenic Mice through Mononucleotide Repeat FrameshiftQ42121380
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosageQ42512972
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's diseaseQ42790645
Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's diseaseQ42792348
Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleusQ43814253
Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate releaseQ44545687
In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD miceQ45290714
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.Q45293425
P921main subjectHuntington's diseaseQ190564
striatumQ1319792
P304page(s)79-89
P577publication date2017-11-07
P1433published inCurrent Opinion in NeurobiologyQ15763572
P1476titleMolecular insights into cortico-striatal miscommunications in Huntington's disease
P478volume48