Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility

scientific article published on 04 July 2013

Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility is …
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scholarly articleQ13442814

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P356DOI10.3389/FNINS.2013.00114
P8608Fatcat IDrelease_sxauwdes5rdk7iv25oslm2ir2i
P932PMC publication ID3701870
P698PubMed publication ID23847463
P5875ResearchGate publication ID248706363

P2093author name stringCarlos Cepeda
Elizabeth A Wang
Michael S Levine
Jane Y Chen
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Dopamine transporter knock-out mice are hypersensitive to 3-nitropropionic acid-induced striatal damage.Q42523227
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Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease miceQ42528338
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Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxiaQ43073344
Response inhibition subprocesses and dopaminergic pathways: basal ganglia disease effectsQ43271068
Release of dopamine evoked by electrical stimulation of the motor and visual areas of the cerebral cortex in both caudate nuclei and in the substantia nigra in the catQ43479489
Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitroQ43517989
D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neuronsQ43582794
Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markersQ43700723
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Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's diseaseQ43925468
Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's diseaseQ43992558
Regulation of neurotransmitter release by synapsin III.Q44012215
The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's diseaseQ44029787
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Striatal neurochemical changes in transgenic models of Huntington's diseaseQ44059847
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Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neuronsQ44463501
Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activityQ44478915
Ziprasidone in Huntington's disease: the first case reportsQ44761187
Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's diseaseQ44806645
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminalsQ44905912
Repetitive behaviors in monkeys are linked to specific striatal activation patterns.Q45030470
By carrot or by stick: cognitive reinforcement learning in parkinsonismQ45140702
Selective striatal neuronal loss in a YAC128 mouse model of Huntington diseaseQ45289366
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Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington's diseaseQ45292669
Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease geneQ37432151
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The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's diseaseQ37646362
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Dysregulation of intracellular dopamine stores revealed in the R6/2 mouse striatumQ37723743
Genetic mouse models of Huntington's disease: focus on electrophysiological mechanismsQ37731940
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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Q37930190
Pharmacologic approaches to the treatment of Huntington's diseaseQ37945478
An evidence-based approach in the treatment of Huntington's disease.Q37969340
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neuronsQ38323909
Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in ratsQ38593346
A zinc finger protein Zfp521 directs neural differentiation and beyondQ39448048
Treatment of Huntington's chorea with bromocriptineQ39820310
Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.Q39933436
Chemical pathology of Huntington's diseaseQ40217253
The psychology of perserverative and stereotyped behaviourQ40576856
Oxidative stress, glutamate, and neurodegenerative disordersQ40618533
Regionally selective roles of the rat's striatum in modality-specific discrimination learning and forelimb reachingQ41230091
Modulation of dopamine neuronal activity by glutamate receptor subtypesQ41509305
Executive and mnemonic functions in early Huntington's diseaseQ45293389
Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's disease mutationQ45293460
Heterogeneous dopamine receptor changes in early and late Huntington's diseaseQ45293500
PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's diseaseQ45294163
Orexin loss in Huntington's disease.Q45295272
Elevated serotonin and reduced dopamine in subregionally divided Huntington's disease striatumQ45295278
Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumesQ45295568
Executive dysfunction in early stages of Huntington's disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study.Q45298559
Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophreniaQ45299102
Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneuronsQ45299250
Quetiapine in the treatment of behavioral disturbances in patients with Huntington's diseaseQ45299623
Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trialQ45300094
Dopamine release is severely compromised in the R6/2 mouse model of Huntington's diseaseQ45300523
Predictive test for Huntington's choreaQ45300600
Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease.Q45302139
Risky decision making in Huntington's diseaseQ45302543
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlationsQ45302799
Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtinQ45302968
Hypersexual features in Huntington's disease.Q45303521
Effects of DA agonist in Huntington disease hyperkinesiaQ45304087
Acute treatment of Huntington's chorea with lisurideQ45304681
Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's diseaseQ45305026
SPECT study of the nigrostriatal dopaminergic system in Huntington's diseaseQ45305746
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 miceQ45306356
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivoQ45306581
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.Q45307012
Mechanisms for synapse specificity during striatal long-term depression.Q45937925
Neuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slicesQ46133563
Pivotal role of early B-cell factor 1 in development of striatonigral medium spiny neurons in the matrix compartmentQ46161329
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.Q46279749
Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatumQ46717751
Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.Q47831483
Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeysQ48088886
The cortico-nigral projection in the rat: an anterograde tracing study with biotinylated dextran amineQ48173382
Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP.Q48226289
Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: relation to thigmotaxisQ48231377
Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivoQ48249875
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memoryQ48285410
Haloperidol interacts with the strychnine-insensitive glycine site at the NMDA receptor in cultured mouse hippocampal neuronesQ48301290
Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigraQ48331606
The human striatum is necessary for responding to changes in stimulus relevanceQ48357068
Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitorQ48461797
Huntington diseaseQ48465200
The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the ratQ48601307
The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systemsQ48614166
Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.Q48616333
Dissociable roles of the ventral, medial and lateral striatum on the acquisition and performance of a complex visual stimulus-response habitQ48622491
D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance.Q48723732
Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidolQ34411138
Under the curve: critical issues for elucidating D1 receptor function in working memoryQ34470592
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.Q34521936
The thalamostriatal system: a highly specific network of the basal ganglia circuitryQ34550491
Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistryQ34707716
Differential electrophysiological changes in striatal output neurons in Huntington's disease.Q34764514
Selective prefrontal cortex inputs to dopamine cells: implications for schizophreniaQ35044635
Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's DiseaseQ35055022
In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's DiseaseQ35116551
Neuropsychiatry of Huntington's diseaseQ35236937
The neostriatal mosaic: multiple levels of compartmental organizationQ35318347
Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learningQ35506425
Dichotomous anatomical properties of adult striatal medium spiny neuronsQ35607269
Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease miceQ35804816
Dopaminergic signaling and striatal neurodegeneration in Huntington's diseaseQ35839434
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcementQ35844174
Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfectQ35913010
Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model miceQ35982759
Levodopa responsive parkinsonism in an adult with Huntington's diseaseQ36318912
Knock-in mouse models of Huntington's diseaseQ36358874
Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it?Q36380359
Biological sources of inflexibility in brain and behavior with aging and neurodegenerative diseasesQ36434965
Striatal dopamine influences the default mode network to affect shifting between object featuresQ36435515
Excitotoxic injury of the neostriatum: a model for Huntington's diseaseQ36586040
Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activatedQ36599964
Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy.Q36602125
Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouseQ36713909
A systematic review of the treatment studies in Huntington's disease since 1990.Q36719669
Obsessive and compulsive symptoms in prediagnosed Huntington's diseaseQ36856810
Motor function and dopamine release measurements in transgenic Huntington's disease model ratsQ36916504
Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognitionQ36989252
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD miceQ37072467
Risperidone and the treatment of psychiatric, motor, and cognitive symptoms in Huntington's disease.Q37093708
Genes, cognition and brain through a COMT lensQ37384503
P921main subjectdopamineQ170304
Huntington's diseaseQ190564
P304page(s)114
P577publication date2013-07-04
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleDopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility
P478volume7