D2R striatopallidal neurons inhibit both locomotor and drug reward processes

scientific article published on 8 March 2009

D2R striatopallidal neurons inhibit both locomotor and drug reward processes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NN.2286
P698PubMed publication ID19270687
P5875ResearchGate publication ID24186085

P50authorMichele ZoliQ42498009
Thorsten BuchQ49971248
Alban de Kerchove d'ExaerdeQ58661148
Serge N. SchiffmannQ41130800
Ari WaismanQ41560798
P2093author name stringStefania Guiducci
Bertrand Bearzatto
Pierre F Durieux
P2860cites workEndocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidolQ46570512
Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons.Q46973834
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and MemoryQ22241980
Neural systems of reinforcement for drug addiction: from actions to habits to compulsionQ29547251
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
The functional anatomy of basal ganglia disordersQ29617461
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
The basal gangliaQ33970931
Regulation of drug-taking and -seeking behaviors by neuroadaptations in the mesolimbic dopamine systemQ35908727
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brainsQ38315630
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.Q40418924
Regulation of glutamic acid decarboxylase gene expression in efferent neurons of the basal gangliaQ40714651
Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function.Q42451194
Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neuronsQ42482886
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)393-395
P577publication date2009-03-08
P1433published inNature NeuroscienceQ1535359
P1476titleD2R striatopallidal neurons inhibit both locomotor and drug reward processes
P478volume12

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cites work (P2860)
Q37692939A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging
Q57296786A competitive model for striatal action selection
Q51740117Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum.
Q67463444Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes.
Q35545487Acute cocaine induces fast activation of D1 receptor and progressive deactivation of D2 receptor striatal neurons: in vivo optical microprobe [Ca2+]i imaging
Q36336421Addiction circuitry in the human brain
Q40638644Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents
Q36754645Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum
Q48215845Age-dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole
Q38655039Alterations in Striatal Circuits Underlying Addiction-Like Behaviors
Q42237758Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens.
Q35156606Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.
Q26768231Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?
Q26269833Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors
Q30573241BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior
Q28508178Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization
Q41878026Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease
Q34473463Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.
Q47836469Bidirectional Control of Reversal in a Dual Action Task by Direct and Indirect Pathway Activation in the Dorsolateral Striatum in Mice.
Q24619737Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Q36214365Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior
Q30595759Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions.
Q48240361Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
Q42037874Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens
Q90110389Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Q40742869Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function.
Q27325489Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers
Q36927168Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).
Q30579307Concurrent activation of striatal direct and indirect pathways during action initiation.
Q26738379Corticostriatal Dysfunction in Huntington's Disease: The Basics
Q41774208D1 and D2 dopamine receptors differentially mediate the activation of phosphoproteins in the striatum of amphetamine-sensitized rats
Q35106605Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 Signaling
Q56873261Deletion of in mice abolishes locomotor and reinforcing effects of cocaine
Q39062836Delta Opioid Receptors: Learning and Motivation
Q47837537Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways
Q40885118Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions.
Q38234309Direct and indirect pathways of basal ganglia: a critical reappraisal
Q34093012Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors
Q36619133Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens.
Q28073389Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity?
Q37237574Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
Q30567117Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry.
Q34454637Dopamine systems adaptation during acquisition and consolidation of a skill
Q57295457Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
Q28276335Dopaminergic neurons inhibit striatal output through non-canonical release of GABA
Q30837855Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
Q38667290ERK/MAPK Signaling Is Required for Pathway-Specific Striatal Motor Functions.
Q34702359Effect of methamphetamine self-administration on neurotensin systems of the basal ganglia
Q48180557Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
Q39353443Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
Q30762059Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling.
Q42974942Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia
Q52311700Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.
Q36398915Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.
Q35328013Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse
Q47121220Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease
Q43882579FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning.
Q35012611Forebrain neurogenesis after focal Ischemic and traumatic brain injury
Q54341612Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice.
Q48139321GPR88 in A2A receptor-expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating.
Q37181488GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors
Q92184901GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior
Q92295837GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum
Q37986616Genetics of dopamine receptors and drug addiction
Q46554230Illuminating Neural Circuits: From Molecules to MRI.
Q36775271Impaired hippocampus-dependent and facilitated striatum-dependent behaviors in mice lacking the δ opioid receptor
Q27023237Individual differences in response to positive and negative stimuli: endocannabinoid-based insight on approach and avoidance behaviors
Q34029003Integrating synaptic plasticity and striatal circuit function in addiction
Q37307186Longitudinal magnetic resonance imaging reveals striatal hypertrophy in a rat model of long-term stimulant treatment
Q39735904Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease.
Q28505365Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist
Q35038095Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement
Q37629974Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future
Q38150698Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field
Q90629460NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control
Q34535855Neurobiology of addiction: a neurocircuitry analysis
Q37778902Neurocomputational models of motor and cognitive deficits in Parkinson's disease
Q37844744Neuromodulatory control of striatal plasticity and behavior.
Q34554358Neuroprotective Functions for the Histone Deacetylase SIRT6
Q36565622Optogenetic Activation of Adenosine A2A Receptor Signaling in the Dorsomedial Striatopallidal Neurons Suppresses Goal-Directed Behavior
Q37608267Optogenetic and chemogenetic insights into the food addiction hypothesis.
Q35952470Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression
Q30500199Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
Q37379987Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation
Q60952522Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization
Q100521473Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain
Q38230498Reassessing models of basal ganglia function and dysfunction
Q41816120Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons
Q48154452Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats
Q36931153Role of the basal ganglia in the control of sleep and wakefulness
Q36554599Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation
Q89393458SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
Q38803243Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice.
Q102075572Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production
Q37047922Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
Q34085579Significance of input correlations in striatal function
Q90044663Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development
Q42164050Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice.
Q41960405Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum
Q36786552Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers
Q36288401Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice
Q30539257Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.
Q52691798Striatal Direct and Indirect Pathway Output Structures are Differentially Altered in Mouse Models of Huntington's Disease.
Q48022291Striatal Local Circuitry: A New Framework for Lateral Inhibition.
Q92851797Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival
Q42637831Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus.
Q38271951Striatal direct and indirect pathways control decision-making behavior.
Q34018614Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity
Q37431197Striatal mechanisms underlying movement, reinforcement, and punishment
Q36203205Striatal microcircuitry and movement disorders
Q40936456Striatopallidal Neuron NMDA Receptors Control Synaptic Connectivity, Locomotor, and Goal-Directed Behaviors
Q37346328Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice
Q30474602Targeting neuronal populations of the striatum
Q42740940Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury
Q26798096The Brain on Drugs: From Reward to Addiction
Q64760299The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
Q41905585The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.
Q38124031The basal ganglia, the ideal machinery for the cost-benefit analysis of action plans
Q28264155The ins and outs of the striatum: role in drug addiction
Q92093313The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens
Q37910746The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
Q64859188Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Q48873079Toward a model of retrograde regulation of striatal synaptic depression.
Q37381132Trajectory of adolescent cannabis use on addiction vulnerability
Q34679428Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
Q37918798Unraveling the differential functions and regulation of striatal neuron sub-populations in motor control, reward, and motivational processes
Q41595563Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.
Q38975392Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity.
Q34201532What is the degree of segregation between striatonigral and striatopallidal projections?
Q33700240Working together: basal ganglia pathways in action selection
Q35707905mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission.