The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons

scientific article published on 18 July 2011

The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/FNANA.2011.00041
P932PMC publication ID3140647
P698PubMed publication ID21811439
P5875ResearchGate publication ID51542415

P50authorEric J. NestlerQ5386788
Mary Kay LoboQ47171856
P2860cites workDARPP-32: regulator of the efficacy of dopaminergic neurotransmissionQ23909380
Allosteric control of an ionotropic glutamate receptor with an optical switch.Q24544302
DeltaFosB: a sustained molecular switch for addictionQ24555194
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine rewardQ24619737
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitryQ24630976
Review. Transcriptional mechanisms of addiction: role of DeltaFosBQ24642005
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviorsQ24645678
Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitizationQ24646964
A genetically encoded photoactivatable Rac controls the motility of living cellsQ24649098
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in miceQ28469322
Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitizationQ28508178
Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine.Q44066984
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaineQ44410508
DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinkingQ44913255
Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascadeQ45077687
Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing studyQ45078410
D2R striatopallidal neurons inhibit both locomotor and drug reward processesQ46095429
Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.Q46446129
Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized miceQ46493142
Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidolQ46570512
Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticityQ46890926
An essential role for DeltaFosB in the nucleus accumbens in morphine actionQ46896171
Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaineQ46975269
Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.Q47637745
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.Q47650443
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons.Q48096315
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapseQ48112100
Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor.Q48218197
Cell type-specific alterations in the nucleus accumbens by repeated exposures to cocaineQ48281473
c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes.Q48331506
Transgenic animals with inducible, targeted gene expression in brainQ48398754
Tonic inhibition of single nucleus accumbens neurons in the rat: a predominant but not exclusive firing pattern induced by cocaine self-administration sessionsQ48417965
Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genesQ48433708
Delta FosB regulates wheel running.Q48488430
The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systemsQ48614166
Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behaviorQ48714883
D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatumQ48828109
Coordinated expression of dopamine receptors in neostriatal medium spiny neuronsQ48890601
Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatumQ48892221
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.Q49116012
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.Q51423988
Retained cocaine conditioned place preference in D1 receptor deficient mice.Q51588458
Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.Q51607325
Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes.Q51780790
Induction of deltaFosB in reward-related brain structures after chronic stress.Q52085449
Striatal c-fos Induction by Cocaine or Apomorphine Occurs Preferentially in Output Neurons Projecting to the Substantia Nigra in the RatQ59574904
Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preferenceQ73616271
Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructsQ81250914
Hold me tightly LOVQ84628710
Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neuronsQ42447206
Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons.Q42448634
Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatumQ42453575
Distribution of adenosine A2 receptor mRNA in the human brainQ42469615
Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behaviorQ42474126
Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neuronsQ42482886
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.Q42913199
Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental contextQ43638169
Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administrationQ43722677
Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbensQ43804898
Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice.Q43990184
Lack of self-administration of cocaine in dopamine D1 receptor knock-out miceQ28511866
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonistsQ28586521
Absence of opiate rewarding effects in mice lacking dopamine D2 receptorsQ28588136
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant miceQ28590091
Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaineQ28591330
Lack of operant ethanol self-administration in dopamine D2 receptor knockout miceQ28592446
Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouseQ28592657
Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient miceQ28593871
Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preferenceQ28594582
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and CortexQ29391304
A translational profiling approach for the molecular characterization of CNS cell typesQ29615252
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
Dopamine, learning and motivationQ29616245
The functional anatomy of basal ganglia disordersQ29617461
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neuronsQ29619181
Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptorsQ30495714
Expression of Cre recombinase in dopaminoceptive neuronsQ33268100
Essential role of the histone methyltransferase G9a in cocaine-induced plasticityQ33646214
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascadeQ33703262
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaineQ33875193
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.Q33940362
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responsesQ33955033
The basal gangliaQ33970931
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviorsQ34093012
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.Q34097122
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaineQ34100505
Techniques for establishing schedules with wheel running as reinforcement in ratsQ34243366
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonistsQ34374970
Is there a common molecular pathway for addiction?Q34463226
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbensQ34480282
Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degenerationQ34583071
Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens.Q34655832
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitizationQ34679428
Cannabinoid receptors: where they are and what they do.Q34772274
FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neuronsQ34774833
Dopamine D2 receptor overexpression alters behavior and physiology in Drd2-EGFP miceQ34780457
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seekingQ34949935
Temporally precise in vivo control of intracellular signallingQ34964618
Insertional mutation of 'classical' and novel genes in transgenic miceQ35646893
Dopamine in drug abuse and addiction: results from imaging studies and treatment implicationsQ35751195
Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficitsQ35990118
The neostriatal mosaic: multiple levels of compartmental organization in the basal gangliaQ36064948
Repeated amphetamine administration outside the home cage enhances drug-induced Fos expression in rat nucleus accumbensQ36260578
Modulation of striatal projection systems by dopamineQ36367283
Expression of the Immediate Early Gene c-fos in Basal Ganglia: Induction by Dopaminergic DrugsQ36527086
Role of ERK in cocaine addiction.Q36644835
TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaineQ36911925
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine cravingQ36953517
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behaviorQ37041735
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in ratsQ37136290
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.Q37167740
Imaging dopamine's role in drug abuse and addictionQ37212526
Molecular mechanisms of psychostimulant-induced structural plasticityQ37325137
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugsQ37332784
Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats.Q37382022
Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptorsQ37400861
Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor geneQ37511116
The glutamate homeostasis hypothesis of addictionQ37538517
Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice.Q37600135
Dopamine receptor gene expression by enkephalin neurons in rat forebrain.Q37662769
Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaineQ37723337
Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuseQ37831649
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brainsQ38315630
Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatumQ38327748
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatumQ38352640
Running and responding reinforced by the opportunity to run: effect of reinforcer durationQ39721635
Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in ratsQ39972608
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine rewardQ42122779
Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behaviorQ42170934
The glucocorticoid receptor as a potential target to reduce cocaine abuse.Q42442957
P921main subjectstriatumQ1319792
substance dependenceQ3378593
P304page(s)41
P577publication date2011-07-18
P1433published inFrontiers in NeuroanatomyQ1893158
P1476titleThe striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
P478volume5

Reverse relations

cites work (P2860)
Q36449674A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking
Q39113054A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action
Q36223595A mutation in CLOCK leads to altered dopamine receptor function
Q90084067A novel role for the actin-binding protein drebrin in regulating opiate addiction
Q96131693A virtual issue highlighting animal studies of eating disorders as valuable tools for examining neurobiological underpinnings and treatment of eating disorders
Q47633748Aberrant approach-avoidance conflict resolution following repeated cocaine pre-exposure.
Q47553528Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Q90457974Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats
Q22251251Addiction science: Uncovering neurobiological complexity
Q22251215Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants
Q42559617Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior
Q48222965Alterations of expression of inflammation/immune-related genes in the dorsal and ventral striatum of adult C57BL/6J mice following chronic oxycodone self-administration: a RNA sequencing study
Q30445194Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience
Q39182855Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.
Q27327277Aversive stimuli drive drug seeking in a state of low dopamine tone
Q50055065Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD.
Q33835356Biological substrates of addiction.
Q33738802CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects
Q34451442Cannabinoid modulation of drug reward and the implications of marijuana legalization
Q92953273Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Q47555197Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.
Q30595759Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions.
Q47297200Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue-induced reinstatement of drug-seeking in rats
Q42037874Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens
Q40742869Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function.
Q34097327Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens.
Q36927168Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).
Q38180393Cocaine-induced changes in NMDA receptor signaling
Q36162140Cocaine-induced synaptic structural modification is differentially regulated by dopamine D1 and D3 receptors-mediated signaling pathways
Q36001660Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
Q38177261Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Q36915480Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons
Q88600927Dissociable roles of the nucleus accumbens D1 and D2 receptors in regulating cue-elicited approach-avoidance conflict decision-making
Q48060287Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement.
Q92163741Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice
Q90654820Dopamine and addiction: what have we learned from 40 years of research
Q90683211Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks
Q21129462Dopamine signaling in reward-related behaviors
Q47264713Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence
Q89433554Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons
Q95825787Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
Q47550488Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics
Q40122849Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.
Q36537790Effects of sodium butyrate on methamphetamine-sensitized locomotor activity
Q89428319Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice
Q90369314Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Q39918479Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding
Q42925606Erratum: Drug-primed reinstatement of cocaine seeking in mice: increased excitability of mediumsized spiny neurons in the nucleus accumbens
Q36439170Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain
Q34602540Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: potential role for 5-HT1B receptor
Q36177070Fluoxetine potentiation of methylphenidate-induced neuropeptide expression in the striatum occurs selectively in direct pathway (striatonigral) neurons
Q48324637Food restriction induces synaptic incorporation of calcium-permeable AMPA receptors in nucleus accumbens
Q39829564Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.
Q89456486Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses
Q37986616Genetics of dopamine receptors and drug addiction
Q39890360GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation
Q27014840Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders
Q47150637Individual differences in the neuropsychopathology of addiction
Q92376205Inhibition of FGF Receptor-1 Suppresses Alcohol Consumption: Role of PI3 Kinase Signaling in Dorsomedial Striatum
Q34029003Integrating synaptic plasticity and striatal circuit function in addiction
Q47234918Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
Q36674162Label-Free Proteomic Analysis of Protein Changes in the Striatum during Chronic Ethanol Use and Early Withdrawal
Q37630530Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.
Q28389962Mechanisms of psychostimulant-induced structural plasticity
Q38371922Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking
Q90629460NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control
Q30585970Natural neural projection dynamics underlying social behavior
Q36451816Neuronal correlates of depression.
Q34383064New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
Q53645958Nuclear Arc Puts a Brake on Cocaine-Induced Chromatin Remodeling and Behaviors.
Q39268133Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress
Q37275079Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
Q37047694Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses.
Q35625766Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action
Q37128118Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking
Q29346962Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Q34330596Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization
Q38442124Oxytocin: parallel processing in the social brain?
Q48284853PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons
Q34122902Pharmacology of novel synthetic stimulants structurally related to the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV).
Q37127848Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward.
Q27000073Recent advances in quantitative neuroproteomics
Q52317816Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.
Q41816120Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons
Q41672595Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal
Q37409569Reverse pharmacogenetic modulation of the nucleus accumbens reduces ethanol consumption in a limited access paradigm
Q37051525Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function
Q90306884Reward, Relief and Habit Drinking: Initial Validation of a Brief Assessment Tool
Q35962060Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain
Q37047922Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
Q30423141Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis.
Q33881046Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Q42321220Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats
Q30539257Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.
Q35688907Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens
Q38271951Striatal direct and indirect pathways control decision-making behavior.
Q37431197Striatal mechanisms underlying movement, reinforcement, and punishment
Q42111195Striatal signaling: two decades of progress.
Q38993666Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.
Q47299273Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Q33559498Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Q38432182Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain
Q92257881The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (ANKK1 Taq1A) and Personality Traits in Addicted Subjects
Q36456708The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle
Q37062547The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
Q92957609The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens
Q40464344The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse.
Q47667543The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Q89532732The changing opioid crisis: development, challenges and opportunities
Q43075979The genetic epidemiology of substance use disorder: A review
Q28253308The habenulo-interpeduncular pathway in nicotine aversion and withdrawal
Q28264155The ins and outs of the striatum: role in drug addiction
Q38187259The vital role of constitutive GPCR activity in the mesolimbic dopamine system
Q30573943Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
Q91718489Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens
Q38975392Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity.
Q42321747WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine
Q90712994Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure
Q94954567cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use
Q37325357ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
Q28251285β-catenin mediates stress resilience through Dicer1/microRNA regulation

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