Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses

scientific article published on 25 June 2018

Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41386-018-0131-8
P932PMC publication ID6180117
P698PubMed publication ID29982266

P50authorBrad A. GrueterQ42822736
P2093author name stringEric Delpire
Brandon D Turner
Max E Joffe
P2860cites workCocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyondQ37828239
The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neuronsQ37910746
GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulationQ39890360
Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function.Q40742869
A silent synapse-based mechanism for cocaine-induced locomotor sensitizationQ41518514
Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens.Q41853424
In vivo cocaine experience generates silent synapses.Q41904475
Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projectionsQ41908316
Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens ProjectionQ42054802
Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia.Q42525723
Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens.Q46738269
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from ExperienceQ47299273
Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior.Q47325157
Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.Q47343579
Infralimbic GluN2A-Containing NMDA Receptors Modulate Reconsolidation of Cocaine Self-Administration MemoryQ47347121
Contrasting forms of cocaine-evoked plasticity control components of relapseQ47868145
A critical role for GluN2B-containing NMDA receptors in cortical development and functionQ48205956
mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell.Q53411111
Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructsQ81250914
Neuroadaptation. Incubation of cocaine craving after withdrawalQ28343773
Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposureQ28577937
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learningQ30494493
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.Q30539257
GluN2B in corticostriatal circuits governs choice learning and choice shifting.Q30541844
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine cravingQ30556607
Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.Q30575221
Synaptic mechanisms underlying persistent cocaine cravingQ33784838
Biological substrates of addiction.Q33835356
Integrating synaptic plasticity and striatal circuit function in addictionQ34029003
Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens.Q34097327
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaineQ34100505
Nucleus accumbens long-term depression and the expression of behavioral sensitization.Q34470662
Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal.Q34578730
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and diseaseQ34651972
Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens.Q34655832
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamineQ34729421
Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine.Q35170246
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.Q35247785
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.Q35749789
D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in RatsQ35960341
Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projectionsQ36001660
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbensQ36713932
Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).Q36927168
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine cravingQ36953517
Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses.Q37047694
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.Q37610891
P433issue12
P1104number of pages7
P304page(s)2383-2389
P577publication date2018-06-25
P1433published inNeuropsychopharmacologyQ2261280
P1476titleGenetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses
P478volume43

Search more.