Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).

scientific article published on 18 February 2013

Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CONB.2013.01.026
P932PMC publication ID3681928
P698PubMed publication ID23428656

P50authorMary Kay LoboQ47171856
Sade SpencerQ54963468
P2093author name stringPeter W Kalivas
Rachel J Smith
P2860cites workThe integrative function of the basal ganglia in instrumental conditioningQ22337367
Using glutamate homeostasis as a target for treating addictive disordersQ24619198
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine rewardQ24619737
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviorsQ24645678
Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in ratsQ42577543
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.Q42913199
Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbensQ43094396
Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in ratsQ44255256
Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum.Q44348883
D2R striatopallidal neurons inhibit both locomotor and drug reward processesQ46095429
Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidolQ46570512
Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals.Q48161635
Cocaine-induced dendritic remodeling occurs in both D1 and D2 dopamine receptor-expressing neurons in the nucleus accumbensQ48164926
Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviourQ48204993
Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbensQ48278620
Cell type-specific alterations in the nucleus accumbens by repeated exposures to cocaineQ48281473
Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbensQ48522950
Two transpallidal pathways originating in the rat nucleus accumbensQ48835505
Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrainQ71489318
Phenotypic characterization of neurotensin messenger RNA-expressing cells in the neuroleptic-treated rat striatum: a detailed cellular co-expression studyQ73306312
Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitizationQ24646964
Neurocircuitry of addictionQ24647156
Mechanisms of psychostimulant-induced structural plasticityQ28389962
Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitizationQ28508178
Specificity in the projection patterns of accumbal core and shell in the rat.Q30451154
Dichotomous dopaminergic control of striatal synaptic plasticityQ30493521
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbensQ30500199
Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitizationQ30527794
Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administrationQ33857187
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seekingQ33944580
Transition to addiction is associated with a persistent impairment in synaptic plasticityQ34122596
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbensQ34480282
The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in ratsQ34641435
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitizationQ34679428
Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistryQ34707716
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamenQ35141659
Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?Q36061698
Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbensQ36140637
A role for kalirin in the response of rat medium spiny neurons to cocaineQ36294402
Modulation of striatal projection systems by dopamineQ36367283
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neuronsQ36590613
Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished ratsQ36978463
N-Acetylcysteine reverses cocaine-induced metaplasticityQ37140681
Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addictionQ37308022
The glutamate homeostasis hypothesis of addictionQ37538517
Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuseQ37702356
Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbensQ37702707
Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyondQ37828239
The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neuronsQ37910746
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.Q39353443
The role of dopamine in modulating the structure and function of striatal circuits.Q40663529
A silent synapse-based mechanism for cocaine-induced locomotor sensitizationQ41518514
Distinct roles for direct and indirect pathway striatal neurons in reinforcement.Q41894840
In vivo cocaine experience generates silent synapses.Q41904475
Interconnected parallel circuits between rat nucleus accumbens and thalamus revealed by retrograde transynaptic transport of pseudorabies virus.Q42435044
Chemical organization of projection neurons in the rat accumbens nucleus and olfactory tubercleQ42445550
Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behaviorQ42474126
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
The mediodorsal nucleus of the thalamus in rats--I. forebrain gabaergic innervationQ42524709
P433issue4
P921main subjectdichotomyQ10361123
P304page(s)546-552
P577publication date2013-02-18
P1433published inCurrent Opinion in NeurobiologyQ15763572
P1476titleCocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).
P478volume23

Reverse relations

cites work (P2860)
Q35536265A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference
Q40290304Acquisition of morphine conditioned place preference increases the dendritic complexity of nucleus accumbens core neurons
Q26996339Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis
Q26768231Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?
Q35626928Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
Q33774757Beyond Neuronal Activity Markers: Select Immediate Early Genes in Striatal Neuron Subtypes Functionally Mediate Psychostimulant Addiction
Q50646906Bi-directional cannabinoid signalling in the basolateral amygdala controls rewarding and aversive emotional processing via functional regulation of the nucleus accumbens.
Q33835356Biological substrates of addiction.
Q48282474Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway
Q52601642Cascades of Homeostatic Dysregulation Promote Incubation of Cocaine Craving.
Q92953273Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Q38954589Changes in Appetitive Associative Strength Modulates Nucleus Accumbens, But Not Orbitofrontal Cortex Neuronal Ensemble Excitability.
Q47297200Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue-induced reinstatement of drug-seeking in rats
Q101403146Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats
Q36042479Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions
Q47670655Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse.
Q36001660Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
Q41169632Computing reward-prediction error: an integrated account of cortical timing and basal-ganglia pathways for appetitive and aversive learning
Q35927537Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction.
Q47868145Contrasting forms of cocaine-evoked plasticity control components of relapse
Q38177261Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Q97536653Decreased Neuronal Excitability in Medial Prefrontal Cortex during Morphine Withdrawal is associated with enhanced SK channel activity and upregulation of small GTPase Rac1
Q26765612Dendritic Spines in Depression: What We Learned from Animal Models
Q40408097Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens
Q52148353Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization.
Q37185190Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine?
Q88600927Dissociable roles of the nucleus accumbens D1 and D2 receptors in regulating cue-elicited approach-avoidance conflict decision-making
Q83231121Distinct roles of striatal direct and indirect pathways in value-based decision making
Q37237574Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
Q38932695Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism
Q50113149Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors
Q47264713Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence
Q95825787Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
Q40122849Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.
Q89428319Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice
Q39015823Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Q30762059Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling.
Q42925606Erratum: Drug-primed reinstatement of cocaine seeking in mice: increased excitability of mediumsized spiny neurons in the nucleus accumbens
Q42278763Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens
Q47236341Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.
Q89456486Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses
Q35809298Gestational stress induces persistent depressive-like behavior and structural modifications within the postpartum nucleus accumbens
Q90108809High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens
Q38950401How contexts promote and prevent relapse to drug seeking.
Q52316112Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.
Q37630530Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.
Q47303917Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors.
Q50083472Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction
Q26830654Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
Q47700053Molecular basis of dendritic atrophy and activity in stress susceptibility
Q92535551Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens
Q49385296N-Methyl-D-Aspartate Receptors: "C"ing the Culprits Behind Cocaine-Induced Metaplasticity
Q39693530Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core
Q30580823Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.
Q36352410Neural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications
Q36451816Neuronal correlates of depression.
Q34383064New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
Q52573379Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors.
Q47549894Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster
Q42248130Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage
Q40737963Nucleus accumbens dopaminergic neurotransmission switches its modulatory action in chronification of inflammatory hyperalgesia
Q39268133Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress
Q40777843Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine
Q50023605Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling
Q37047694Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses.
Q35625766Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action
Q42452997Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory
Q37128118Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking
Q35558068Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior
Q34330596Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization
Q34122902Pharmacology of novel synthetic stimulants structurally related to the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV).
Q36031693Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene
Q39067400Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
Q93349778Prefrontal-accumbens opioid plasticity: Implications for relapse and dependence
Q48104528Regional Differences in Striatal Neuronal Ensemble Excitability Following Cocaine and Extinction Memory Retrieval in Fos-GFP Mice
Q52317816Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.
Q36498162Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement
Q39190673Reward Circuitry in Addiction
Q36056699Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning
Q26746516Safety out of control: dopamine and defence
Q38803243Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice.
Q38684551Silent Synapse-Based Circuitry Remodeling in Drug Addiction.
Q38993666Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.
Q47299273Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Q39381131Synaptic functions of endocannabinoid signaling in health and disease
Q33784838Synaptic mechanisms underlying persistent cocaine craving
Q26798096The Brain on Drugs: From Reward to Addiction
Q36588705The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice
Q36480233The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons
Q37062547The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
Q50248388The Winding Road to Relapse: Forging a New Understanding of Cue-Induced Reinstatement Models and Their Associated Neural Mechanisms
Q41173240The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging
Q28264155The ins and outs of the striatum: role in drug addiction
Q92987643The molecular and cellular mechanisms of depression: a focus on reward circuitry
Q50331928Tipping the Scales Toward Addiction.
Q37479497Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.
Q48126745Trait and state binge eating predispose towards cocaine craving.
Q48058857Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence.
Q91718489Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens
Q48262090Ventral pallidal projections to mediodorsal thalamus and ventral tegmental area play distinct roles in outcome-specific Pavlovian-instrumental transfer.
Q53411111mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell.
Q37325357ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
Q37502495δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice.

Search more.