Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol

scientific article published in May 2008

Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.1039-08.2008
P932PMC publication ID6670792
P698PubMed publication ID18509028

P50authorMiriam MatamalesQ47815491
Emmanuel ValjentQ60619638
Jesus Bertran-GonzalezQ83214648
Matthieu MaroteauxQ87625200
Denis HervéQ89045564
Jean-Antoine GiraultQ33122764
P2093author name stringClémentine Bosch
P2860cites workComputational models of the basal ganglia: from robots to membranesQ22337305
Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatumQ24557423
A neural substrate of prediction and rewardQ27860851
Addiction, dopamine, and the molecular mechanisms of memoryQ28142501
Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.Q46843660
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models.Q46896175
Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons.Q46973834
Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation.Q47587756
Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage.Q47590939
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.Q47650443
Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons.Q48096315
Repeated amphetamine treatment increases phosphorylation of extracellular signal-regulated kinase, protein kinase B, and cyclase response element-binding protein in the rat striatumQ48102523
Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesiaQ48124096
Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaineQ48339954
Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation.Q48367956
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.Q48691508
Coordinated expression of dopamine receptors in neostriatal medium spiny neuronsQ48890601
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.Q51423988
Differential induction of Fos protein and a Fos-related antigen following acute and repeated cocaine administration.Q51627980
Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system.Q52067929
D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAS in distinct neuronal populations of the dorsal and ventral striatumQ61762612
Dose-dependent alteration in zif/268 and preprodynorphin mRNA expression induced by amphetamine or methamphetamine in rat forebrainQ72241216
D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrainQ72244610
Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructsQ81250914
Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatumQ28512674
Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin geneQ28571661
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and CortexQ29391304
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatumQ29620475
Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.Q30594829
Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatumQ30945230
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaineQ33610933
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumQ33723743
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preferenceQ34479672
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbensQ34480282
The basal ganglia and motor controlQ35593766
Functional diversity and specificity of neostriatal interneurons.Q35974955
Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes.Q36012516
ERK2: a logical AND gate critical for drug-induced plasticity?Q36644968
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brainsQ38315630
Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatumQ38327748
Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.Q38342952
MSK1 activity is controlled by multiple phosphorylation sites.Q40487132
Striatal interneurones: chemical, physiological and morphological characterizationQ40991491
Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: light and electron microscopyQ42480393
Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine.Q42494695
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawalQ42521545
Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental contextQ43638169
D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase.Q44037073
Locomotor sensitization to cocaine is associated with increased Fos expression in the accumbens, but not in the caudateQ44214732
D1 and D2 dopamine receptors differentially regulate c-fos expression in striatonigral and striatopallidal neuronsQ44243782
Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context.Q44478481
Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatumQ44519012
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.Q44840053
Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptorsQ44854959
Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidolQ45014695
Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascadeQ45077687
Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memoryQ46269232
ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian miceQ46684571
Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A.Q46747418
Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway.Q46786033
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
striatumQ1319792
P304page(s)5671-5685
P577publication date2008-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleOpposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol
P478volume28

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cites work (P2860)
Q91884739A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell
Q35024117A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression
Q57296786A competitive model for striatal action selection
Q97424890A dopamine-induced gene expression signature regulates neuronal function and cocaine response
Q40774245A network model of basal ganglia for understanding the roles of dopamine and serotonin in reward-punishment-risk based decision making
Q24649092A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization
Q91260549A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine
Q47553528Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Q24655259Activation of calcium/calmodulin-dependent protein kinase IIalpha in the striatum by the heteromeric D1-D2 dopamine receptor complex
Q35545487Acute cocaine induces fast activation of D1 receptor and progressive deactivation of D2 receptor striatal neurons: in vivo optical microprobe [Ca2+]i imaging
Q36336421Addiction circuitry in the human brain
Q35060382Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Q35766214Adolescent brain maturation is necessary for adult-typical mesocorticolimbic responses to a rewarding social cue.
Q38215870Advances in the neurobiological bases for food 'liking' versus 'wanting'.
Q35968110Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum.
Q48224761Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation
Q36536725Amphetamine increases phosphorylation of MAPK/ERK at synaptic sites in the rat striatum and medial prefrontal cortex
Q35039492An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons
Q38921547An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning.
Q33607061Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus
Q41654494Antagonism of Muscarinic Acetylcholine Receptors Alters Synaptic ERK Phosphorylation in the Rat Forebrain
Q33777656Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity
Q30593958Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation
Q30573241BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior
Q34613571BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.
Q35208420Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments
Q34473463Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.
Q30440366Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments
Q33774757Beyond Neuronal Activity Markers: Select Immediate Early Genes in Striatal Neuron Subtypes Functionally Mediate Psychostimulant Addiction
Q90746533Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia
Q34029497CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors
Q24656080Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
Q37678864Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum
Q58695416Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice
Q24619737Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Q59136350Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell
Q60907600Cell-Type-Specific Proteomics: A Neuroscience Perspective
Q92953273Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Q34090607Cell-type specific expression of p11 controls cocaine reward
Q30595759Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions.
Q36889608Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency
Q37208488Chronic cocaine dampens dopamine signaling during cocaine intoxication and unbalances D1 over D2 receptor signaling
Q28570413Chronic methamphetamine exposure suppresses the striatal expression of members of multiple families of immediate early genes (IEGs) in the rat: normalization by an acute methamphetamine injection
Q27322672Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice
Q90110389Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Q30538086Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
Q47967492Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area
Q37617361Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.
Q89032160Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens
Q36927168Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).
Q38180393Cocaine-induced changes in NMDA receptor signaling
Q36001660Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
Q35222697Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans
Q37253349Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice
Q42504124Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum.
Q47868145Contrasting forms of cocaine-evoked plasticity control components of relapse
Q38177261Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Q26825464Current status and future prospects for epigenetic psychopharmacology
Q41774208D1 and D2 dopamine receptors differentially mediate the activation of phosphoproteins in the striatum of amphetamine-sensitized rats
Q30451613D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms
Q34628184D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses
Q46095429D2R striatopallidal neurons inhibit both locomotor and drug reward processes
Q38775994D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells
Q35201971DARPP-32, Jack of All Trades… Master of Which?
Q35106605Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 Signaling
Q38183356Decoding spatial and temporal features of neuronal cAMP/PKA signaling with FRET biosensors
Q26765612Dendritic Spines in Depression: What We Learned from Animal Models
Q41683110Depression and addiction comorbidity: towards a common molecular target?
Q47985284Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons
Q40408097Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens
Q47837537Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways
Q36915480Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons
Q34764514Differential electrophysiological changes in striatal output neurons in Huntington's disease.
Q40885118Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions.
Q34276531Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine
Q37442803Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum
Q48597825Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption.
Q34472138Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
Q36619133Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens.
Q34020446Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking
Q38823507Dopamine D1 or D2 receptor-expressing neurons in the central nervous system
Q37772934Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration
Q24620977Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2
Q21134725Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2
Q21198880Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Q24312888Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268
Q92163741Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice
Q37346794Dopamine D2 receptors in striatal output neurons enable the psychomotor effects of cocaine
Q90654820Dopamine and addiction: what have we learned from 40 years of research
Q42579414Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons
Q37437948Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Q48531888Dopamine receptor agonist treatment for idiopathic dystonia: A reappraisal in humans and mice
Q37242424Dopamine receptor homooligomers and heterooligomers in schizophrenia
Q28256783Dopamine receptors - IUPHAR Review 13
Q48114419Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease.
Q36322691Dorsal and ventral streams: the distinct role of striatal subregions in the acquisition and performance of goal-directed actions.
Q95825787Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens
Q41810806Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome
Q38667290ERK/MAPK Signaling Is Required for Pathway-Specific Striatal Motor Functions.
Q42512829Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures.
Q34417283Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns
Q48404644Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons
Q45997940Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.
Q34630009Epigenetic mechanisms in cognition
Q22251252Epigenetic mechanisms of drug addiction
Q38207893Epigenetic regulation of memory by acetylation and methylation of chromatin: implications in neurological disorders, aging, and addiction
Q34254501Epigenetic signaling in psychiatric disorders.
Q37877119Epigenetic treatments for cognitive impairments
Q38040133Epigenetics of psychoactive drugs
Q42925606Erratum: Drug-primed reinstatement of cocaine seeking in mice: increased excitability of mediumsized spiny neurons in the nucleus accumbens
Q52311700Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.
Q47222763Estrogen Receptor βin the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice
Q27320053Evidence against dopamine D1/D2 receptor heteromers
Q35328013Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse
Q28583223Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat
Q42510225Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats.
Q43882579FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning.
Q46908291Fluorescence-activated sorting of fixed nuclei: a general method for studying nuclei from specific cell populations that preserves post-translational modifications.
Q38327842Fluorescent knock-in mice to decipher the physiopathological role of G protein-coupled receptors
Q93195759Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum
Q41790827Functional neuroanatomy of the basal ganglia
Q40133897Functionally Distinct Dopamine Signals in Nucleus Accumbens Core and Shell in the Freely Moving Rat.
Q38834292G protein-coupled receptor kinases as regulators of dopamine receptor functions
Q37366908Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
Q64092426Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs
Q37578749Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine
Q33112258Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
Q35356825Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32
Q39735652Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain
Q37379456Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance
Q24652245Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
Q41814232Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.
Q28078491How compensation breaks down in Parkinson's disease: Insights from modeling of denervated striatum
Q42867430Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum
Q39066006Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells
Q42913199Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.
Q27303742Increased histone H3 phosphorylation in neurons in specific brain structures after induction of status epilepticus in mice
Q54981672Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors.
Q38968515Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain
Q27026279Investigating striatal function through cell-type-specific manipulations
Q92881663Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci
Q46136644L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
Q27021825Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry
Q89713018Learned avoidance requires VTA KOR-mediated reductions in dopamine
Q55122086Linking spatial gene expression patterns to sex-specific brain structural changes on a mouse model of 16p11.2 hemideletion.
Q33825588Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex
Q37325736Loss of DARPP-32 and calbindin in multiple system atrophy
Q37630530Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.
Q47241090Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders
Q44077065Mathematical model of dopamine autoreceptors and uptake inhibitors and their influence on tonic and phasic dopamine signaling
Q37157765Maturation of coordinated immediate early gene expression by cocaine during adolescence
Q46108447Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult
Q21131062Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons
Q41539028Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways
Q38771065Mechanisms of kappa opioid receptor potentiation of dopamine D2 receptor function in quinpirole-induced locomotor sensitization in rats.
Q37479889Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol.
Q28389962Mechanisms of psychostimulant-induced structural plasticity
Q22248089Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens
Q26851389Modeling intracellular signaling underlying striatal function in health and disease
Q26830654Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
Q37671995Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects.
Q27022879Molecular and neuronal plasticity mechanisms in the amygdala-prefrontal cortical circuit: implications for opiate addiction memory formation
Q37629974Molecular profiling of striatonigral and striatopallidal medium spiny neurons past, present, and future
Q27008450Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs
Q92535551Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens
Q38362579Morphological elucidation of basal ganglia circuits contributing reward prediction.
Q41691971NCS-Rapgef2, the Protein Product of the Neuronal Rapgef2 Gene, Is a Specific Activator of D1 Dopamine Receptor-Dependent ERK Phosphorylation in Mouse Brain
Q36985785NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference
Q37032858Neurochemical and behavioural indices of exercise reward are independent of exercise controllability
Q39405720Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation
Q24602643Neurogenetics and pharmacology of learning, motivation, and cognition
Q38172953Neuronal activity-regulated gene transcription: how are distant synaptic signals conveyed to the nucleus?
Q49529875Norepinephrine in the Medial Pre-frontal Cortex Supports Accumbens Shell Responses to a Novel Palatable Food in Food-Restricted Mice Only.
Q37970016Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop
Q53645958Nuclear Arc Puts a Brake on Cocaine-Induced Chromatin Remodeling and Behaviors.
Q52573379Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors.
Q42917768Nucleus accumbens core neurons encode value-independent associations necessary for sensory preconditioning
Q35216624Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear
Q37555175Olfactory maps, circuits and computations
Q96953338One Is Not Enough: Understanding and Modeling Polysubstance Use
Q50023605Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling
Q28742022Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons
Q29346962Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Q59349575Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence
Q98303124Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
Q48284853PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons
Q35207454Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia
Q37117611Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology
Q35161141Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice.
Q37809494Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation
Q39067400Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
Q41850307Preadolescent drd1-EGFP mice exhibit cocaine-induced behavioral sensitization
Q35127508Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration
Q93349778Prefrontal-accumbens opioid plasticity: Implications for relapse and dependence
Q37642472Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses
Q60952522Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization
Q37498702Rapid dopamine dynamics in the accumbens core and shell: learning and action
Q39348706Ras-ERK Signaling in Behavior: Old Questions and New Perspectives
Q42175909Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.
Q34239363Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor
Q92319225Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress
Q28574293Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats
Q42290222Reduction of Cocaine-Induced Locomotor Effects by Enriched Environment Is Associated with Cell-Specific Accumulation of ΔFosB in Striatal and Cortical Subregions
Q35742267Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer
Q39243689Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases
Q35985571Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors
Q37576366Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum
Q35269480Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity
Q36821311Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism
Q42699608Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease.
Q48204993Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
Q36498162Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement
Q41312084Role of Dopamine D1 Receptors in the Activation of Nucleus Accumbens Extracellular Signal-Regulated Kinase (ERK) by Cocaine-Paired Contextual Cues
Q41649807Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors
Q34243787Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine
Q30946517Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice
Q41888219Role of the plasticity-associated transcription factor zif268 in the early phase of instrumental learning
Q28066246Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction
Q26746516Safety out of control: dopamine and defence
Q28395155Segregation and crosstalk of D1 receptor-mediated activation of ERK in striatal medium spiny neurons upon acute administration of psychostimulants
Q28390499Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3)
Q38803243Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice.
Q37679301Selective expression of a dominant-negative type Iα PKA regulatory subunit in striatal medium spiny neurons impairs gene expression and leads to reduced feeding and locomotor activity
Q47249694Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses.
Q37903674Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons
Q36361964Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction.
Q30527794Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitization
Q41960405Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum
Q46127916Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates
Q53481362Stay alert, don't get hurt.
Q42321220Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats
Q30435564Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer
Q35688907Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens
Q103804472Stress and the dopaminergic reward system
Q37023040Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
Q41684455Stress-Induced Reduction of Dorsal Striatal D2 Dopamine Receptors Prevents Retention of a Newly Acquired Adaptive Coping Strategy.
Q44128244Stress-induced brain histone H3 phosphorylation: contribution of the intensity of stressors and length of exposure
Q48022291Striatal Local Circuitry: A New Framework for Lateral Inhibition.
Q37609566Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
Q46145089Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia
Q37431197Striatal mechanisms underlying movement, reinforcement, and punishment
Q21143854Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice
Q28385866Striatal neurones have a specific ability to respond to phasic dopamine release
Q36388869Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1α in zebrafish
Q36713932Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
Q48272772TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia
Q30474602Targeting neuronal populations of the striatum
Q28543523Temporal and spatial transcriptional fingerprints by antipsychotic or propsychotic drugs in mouse brain
Q92641994The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice
Q92849587The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms
Q37317832The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons.
Q37062547The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
Q47667543The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Q33455500The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction
Q35696518The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization
Q24608243The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia
Q42749859The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury
Q21131063The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia
Q38189780The emerging role of dopamine-glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: Implications for treatment
Q28264155The ins and outs of the striatum: role in drug addiction
Q37910746The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
Q90950669The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
Q37393306The thalamostriatal pathway and cholinergic control of goal-directed action: interlacing new with existing learning in the striatum.
Q22251017Transcriptional and epigenetic mechanisms of addiction
Q43913445Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens
Q37918798Unraveling the differential functions and regulation of striatal neuron sub-populations in motor control, reward, and motivational processes
Q41595563Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.
Q36727004Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model
Q35593880Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction
Q100559899Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway
Q48262090Ventral pallidal projections to mediodorsal thalamus and ventral tegmental area play distinct roles in outcome-specific Pavlovian-instrumental transfer.
Q47811667Visualizing an emotional valence map in the limbic forebrain by TAI-FISH.
Q30371197Voluntary exercise during extinction of auditory fear conditioning reduces the relapse of fear associated with potentiated activity of striatal direct pathway neurons
Q88671319What does dopamine mean?
Q34201532What is the degree of segregation between striatonigral and striatopallidal projections?
Q35614046Whole genome methylation analyses of schizophrenia patients before and after treatment
Q40084436Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle
Q54225221[Physiopathology of cAMP/PKA signaling in neurons].
Q48398035drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus
Q37325357ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
Q37502495δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice.