Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs

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Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs is …
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P6179Dimensions Publication ID1039846169
P356DOI10.1038/NPP.2012.120
P3181OpenCitations bibliographic resource ID1267223
P932PMC publication ID3521966
P698PubMed publication ID22968819
P5875ResearchGate publication ID230833280

P2093author name stringPaul J Kenny
Sietse Jonkman
P2860cites workHuman MicroRNA targetsQ21563637
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2Q22337290
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DARPP-32: regulator of the efficacy of dopaminergic neurotransmissionQ23909380
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporterQ24310836
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexQ24324026
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesisQ24537628
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MeCP2, a key contributor to neurological disease, activates and represses transcriptionQ24647533
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Homeostatic regulation of MeCP2 expression by a CREB-induced microRNAQ28256854
Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine actionQ28269125
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detectorQ28285140
Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbensQ28350945
Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant miceQ28372752
Striatal microRNA controls cocaine intake through CREB signallingQ28397558
DARPP-32 is a robust integrator of dopamine and glutamate signalsQ28469090
A phosphatase cascade by which rewarding stimuli control nucleosomal responseQ28508656
Requirement of TORC1 for late-phase long-term potentiation in the hippocampusQ28564368
Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brainQ28579363
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212.Q28909710
Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutationsQ28941188
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A brain-specific microRNA regulates dendritic spine developmentQ29614753
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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving ratsQ29619737
Central amygdala ERK signaling pathway is critical to incubation of cocaine cravingQ45229251
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Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidolQ46570512
Involvement of the dorsal striatum in cue-controlled cocaine seeking.Q46715134
Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio sizeQ47402091
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.Q47650443
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapseQ48112100
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Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking.Q48174532
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Anterograde transport of brain-derived neurotrophic factor and its role in the brainQ48539947
Bidirectional regulation of DARPP-32 phosphorylation by dopamine.Q48617260
Effects of dose and session duration on cocaine self-administration in ratsQ48631930
Prolonged and extrasynaptic excitatory action of dopamine mediated by D1 receptors in the rat striatum in vivoQ48654037
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expressionQ48667829
Cocaine medications, cocaine consumption and societal costsQ48849772
Cocaine self-administration "binges": transition from behavioral and autonomic regulation toward homeostatic dysregulation in rats.Q51368223
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.Q51423988
Withdrawal from i.v. cocaine "binges" in rats: ultrasonic distress calls and startle.Q51528848
Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice.Q51588772
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat.Q51594250
Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat.Q51824593
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CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
The Creb1 coactivator Crtc1 is required for energy balance and fertilityQ30439853
Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labelingQ33254262
Essential role of the histone methyltransferase G9a in cocaine-induced plasticityQ33646214
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbensQ33667218
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumQ33723743
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaineQ33875193
Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expressionQ34012291
Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in malesQ34021143
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addictionQ34096507
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodelingQ34166000
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaineQ34186133
A role for repressive histone methylation in cocaine-induced vulnerability to stressQ34210889
High dose cocaine use in São Paulo: a comparison of treatment and community samples.Q34233821
CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatumQ34245266
Regulation of gene expression and cocaine reward by CREB and ΔFosBQ34270890
Enhancement of cellular memory by reducing stochastic transitionsQ34418258
Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior.Q34456299
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbensQ34480282
Regulation of cocaine reward by CREB.Q34483870
Shift from goal-directed to habitual cocaine seeking after prolonged experience in ratsQ34777038
Pharmacotherapy of addictionsQ34810395
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preferenceQ34820236
Different lengths of times for progressions in adolescent substance involvementQ34928953
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.Q34964519
Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbensQ35148825
microRNA-Seq reveals cocaine-regulated expression of striatal microRNAsQ35157752
Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering ratsQ35588162
Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine.Q35622653
Satiating effects of cocaine are controlled by dopamine actions in the nucleus accumbens coreQ35689736
Imbalance between drug and non-drug reward availability: a major risk factor for addictionQ36303086
MicroRNAs in neuronal function and dysfunctionQ36589809
Brain reward systems and compulsive drug use.Q36727520
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugsQ37332784
MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB productionQ38295410
Cocaine dependenceQ38639788
Opioids: Similarity between evaluations of subjective effects and animal self-administration resultsQ39659438
Changing patterns of cocaine use: longitudinal observations, consequences, and treatmentQ40215379
A range of research-based pharmacotherapies for addictionQ41602489
Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administrationQ41785882
Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatumQ41922304
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine rewardQ42122779
TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons.Q42450038
Transition from moderate to excessive drug intake: change in hedonic set point.Q42539135
Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatumQ42867430
microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticityQ43286906
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.Q43553698
Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administrationQ43763132
Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1.Q43960577
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use.Q44021767
Drug use expectancies among nonabstinent community cocaine usersQ44069915
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving.Q44306921
Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaineQ44328326
Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learningQ44747862
A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.Q44770115
Differential control over cocaine-seeking behavior by nucleus accumbens core and shellQ44807770
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in ratsQ44892892
Evidence for addiction-like behavior in the rat.Q45018179
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
cocaine dependenceQ3743188
cocaineQ41576
P304page(s)198-211
P577publication date2013-01-01
P1433published inNeuropsychopharmacologyQ2261280
P1476titleMolecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs
P478volume38

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