The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.

scientific article

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TINS.2010.02.002
P932PMC publication ID2891948
P698PubMed publication ID20207024
P5875ResearchGate publication ID41807659

P50authorDavid M DietzQ52689188
Scott J. RussoQ56501528
P2093author name stringEric J Nestler
Robert C Malenka
John H Morrison
Dani Dumitriu
P2860cites workWAVE, a novel WASP-family protein involved in actin reorganization induced by RacQ22008483
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbensQ22248089
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPQ24318478
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesisQ24537628
Review. Transcriptional mechanisms of addiction: role of DeltaFosBQ24642005
Distinct patterns of DeltaFosB induction in brain by drugs of abuseQ24645131
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuinsQ24654085
Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.Q24681363
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.Q27863780
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirinQ28114923
The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spinesQ28115750
Changing subunit composition of heteromeric NMDA receptors during development of rat cortexQ28251123
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatumQ28267577
Cdk5 modulates cocaine reward, motivation, and striatal neuron excitabilityQ28508380
Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5Q28568627
Induction of spine growth and synapse formation by regulation of the spine actin cytoskeletonQ28570265
Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticityQ28593050
Vav2 is an activator of Cdc42, Rac1, and RhoAQ28610652
Structural basis of long-term potentiation in single dendritic spinesQ29547598
A translational profiling approach for the molecular characterization of CNS cell typesQ29615252
Transient and persistent dendritic spines in the neocortex in vivoQ29618402
Long-term potentiation--a decade of progress?Q29619421
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatumQ29620475
The many faces of CREBQ29622920
Molecular mechanisms of dendritic spine morphogenesisQ29903592
Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortexQ31911165
Essential role of the histone methyltransferase G9a in cocaine-induced plasticityQ33646214
Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinasesQ33796391
Development of long-term dendritic spine stability in diverse regions of cerebral cortexQ33986592
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoAQ34011759
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviorsQ34093012
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaineQ34100505
Signalling and crosstalk of Rho GTPases in mediating axon guidance.Q34168199
Regulation of gene expression and cocaine reward by CREB and ΔFosBQ34270890
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbensQ34480282
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates.Q34586869
Do thin spines learn to be mushroom spines that remember?Q34627910
Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens.Q34655832
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seekingQ34949935
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.Q34964519
Cocaine increases actin cycling: effects in the reinstatement model of drug seeking.Q46923595
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.Q47650443
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapseQ48112100
Opposing functions of CREB and MKK1 synergistically regulate the geometry of dendritic spines in visual cortexQ48141995
Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaineQ48228519
Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine.Q48617102
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphologyQ57987174
Generation of silent synapses by acute in vivo expression of CaMKIV and CREBQ81480572
Molecular mechanisms of drug addictionQ35229411
Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticityQ35700587
Structural plasticity associated with exposure to drugs of abuseQ35908693
Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding proteinQ35997966
Spine architecture and synaptic plasticityQ36088576
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complexQ36450248
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spinesQ36498526
The sequence of events that underlie quantal transmission at central glutamatergic synapsesQ36885427
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine cravingQ36953517
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse developmentQ37081722
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticityQ37163643
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbensQ37194651
Neurotrophic factors and structural plasticity in addictionQ37223964
Altered dendritic spine plasticity in cocaine-withdrawn ratsQ37233538
Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neuronsQ37316191
Molecular mechanisms of psychostimulant-induced structural plasticityQ37325137
Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons.Q37463741
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.Q41312875
In vivo cocaine experience generates silent synapses.Q41904475
Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behaviorQ42170934
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.Q42175909
Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studiesQ42767387
Two-color, two-photon uncaging of glutamate and GABAQ42796793
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.Q42825535
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.Q43553698
Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiationQ43699789
Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.Q43972763
Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult ratsQ44175285
Regulation of CRE-mediated transcription in mouse brain by amphetamineQ44296071
Morphine exposure and abstinence define specific stages of gene expression in the rat nucleus accumbensQ44807374
The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbensQ45049933
The expanding role of PSD-95: a new link to addictionQ45149180
Bidirectional activity-dependent morphological plasticity in hippocampal neuronsQ45168485
Cocaine regulates ezrin-radixin-moesin proteins and RhoA signaling in the nucleus accumbens.Q45938170
Plasticity of reward neurocircuitry and the 'dark side' of drug addictionQ46177203
Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental areaQ46210359
Cocaine-evoked synaptic plasticity: a key to addiction?Q46522113
BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawalQ46586263
Homer isoforms differentially regulate cocaine-induced neuroplasticity.Q46701582
Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoformsQ46718702
Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens.Q46738269
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seekingQ46751653
An essential role for DeltaFosB in the nucleus accumbens in morphine actionQ46896171
P433issue6
P921main subjectnucleus accumbensQ1476178
P304page(s)267-276
P577publication date2010-03-05
P1433published inTrends in NeurosciencesQ3538443
P1476titleThe addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
P478volume33

Reverse relations

cites work (P2860)
Q26770749A Framework for Understanding the Emerging Role of Corticolimbic-Ventral Striatal Networks in OCD-Associated Repetitive Behaviors
Q57461570A Model of Δ-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens
Q47278358A Novel Role for Oligodendrocyte Precursor Cells (OPCs) and Sox10 in Mediating Cellular and Behavioral Responses to Heroin
Q58601391A computational strategy for finding novel targets and therapeutic compounds for opioid dependence
Q45303860A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington's disease
Q37157966A multistep general theory of transition to addiction.
Q47846448A new automated 3D detection of synaptic contacts reveals the formation of cortico-striatal synapses upon cocaine treatment in vivo.
Q90084067A novel role for the actin-binding protein drebrin in regulating opiate addiction
Q35757839A pivotal role of GSK-3 in synaptic plasticity.
Q89455807A review of peripheral brain-derived neurotrophic factor levels in alcohol-dependent patients: Current understanding
Q45260924A systems medicine research approach for studying alcohol addiction
Q33683315AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
Q38705417ASIC1A in neurons is critical for fear-related behaviors.
Q33969340Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.
Q90595012Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control
Q30841140Activin A is increased in the nucleus accumbens following a cocaine binge
Q27312301Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity
Q35888261Acute Morphine, Chronic Morphine, and Morphine Withdrawal Differently Affect Pleiotrophin, Midkine, and Receptor Protein Tyrosine Phosphatase β/ζ Regulation in the Ventral Tegmental Area
Q92967463Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An In Vivo Electrophysiological Study
Q35801356Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats
Q50541038Addictive behaviour in experimental animals: prospects for translation.
Q57039661Adolescent exposure to Δ-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons
Q33678853Adult female rats' altered diurnal locomotor activity pattern following chronic methylphenidate treatment
Q26738370Advanced Fluorescence Protein-Based Synapse-Detectors
Q35968110Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum.
Q55428945Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons.
Q34676109Amphetamine-induced sensitization has little effect on multiple learning paradigms and fails to rescue mice with a striatal learning defect
Q38138785An integrated quantitative proteomics and systems biology approach to explore synaptic protein profile changes during morphine exposure
Q42126211Anabolic-androgenic steroids decrease dendritic spine density in the nucleus accumbens of male rats
Q30447847Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity
Q39066739Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction
Q38655315Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine
Q26768231Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?
Q34304358BDNF is a negative modulator of morphine action
Q40648892BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior
Q35208420Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments
Q34959505Behavioral and neuronal recording of the nucleus accumbens in adolescent rats following acute and repetitive exposure to methylphenidate
Q36856397Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell
Q33774757Beyond Neuronal Activity Markers: Select Immediate Early Genes in Striatal Neuron Subtypes Functionally Mediate Psychostimulant Addiction
Q34273065Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy
Q38267155Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.
Q33835356Biological substrates of addiction.
Q93380686Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core
Q41061073Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.
Q41848840COPI polices nicotine-mediated up-regulation of nicotinic receptors
Q33738802CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects
Q27323026CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy
Q48033935Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
Q36061698Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
Q36551838Caudate neuronal recording in freely behaving animals following acute and chronic dose response methylphenidate exposure
Q28570368Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway
Q59136350Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell
Q24615131Cellular basis of memory for addiction
Q27315333Chronic Alcohol Exposure is Associated with Decreased Neurogenesis, Aberrant Integration of Newborn Neurons, and Cognitive Dysfunction in Female Mice
Q89834405Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes
Q41286804Chronic alcohol exposure increases ganglia endogenous morphine levels.
Q28576662Chronic cocaine administration causes extensive white matter damage in brain: diffusion tensor imaging and immunohistochemistry studies
Q60912864Chronic treatment with N-acetylcysteine decreases extinction responding and reduces cue-induced nicotine-seeking
Q26770416Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Q39131116Circadian Rhythms and Substance Abuse: Chronobiological Considerations for the Treatment of Addiction
Q47366166Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking.
Q90955773Cocaine addicted to cytoskeletal change and a fibrosis high
Q34097327Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens.
Q47598515Cocaine increases dopaminergic connectivity in the nucleus accumbens
Q47768695Cocaine preexposure enhances sexual conditioning and increases resistance to extinction in male Japanese quail
Q36557046Cocaine produces conditioned place aversion in mice with a cocaine-insensitive dopamine transporter
Q38258716Cocaine triggers epigenetic alterations in the corticostriatal circuit
Q34544268Cocaine‐ and morphine‐induced synaptic plasticity in the nucleus accumbens
Q47999342Comparison of the MK-801-induced increase in non-rewarded appetitive responding with dopamine agonists and locomotor activity in rats
Q28389040Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration
Q36565674Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli
Q38805967Corticostriatal circuitry in regulating diseases characterized by intrusive thinking
Q48009353Cross-talk between the epigenome and neural circuits in drug addiction.
Q38025589Deep brain stimulation for psychiatric disease: contributions and validity of animal models
Q37935518Deep brain stimulation in addiction: a review of potential brain targets
Q30240579Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products
Q34769526DiOlistic labeling in fixed brain slices: phenotype, morphology, and dendritic spines
Q36105477Differential modulation of drug-induced structural and functional plasticity of dendritic spines
Q37185190Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine?
Q47925108Diolistic Labeling and Analysis of Dendritic Spines.
Q35098064Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems
Q34086476Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Q90654820Dopamine and addiction: what have we learned from 40 years of research
Q41837655Dopamine-glutamate interplay in the ventral striatum modulates spatial learning in a receptor subtype-dependent manner.
Q39747612Dopaminergic Balance between Reward Maximization and Policy Complexity
Q89433554Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons
Q34166000Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Q48555400Dynamic Alterations of Rat Nucleus Accumbens Dendritic Spines over 2 Months of Abstinence from Extended-Access Cocaine Self-Administration.
Q34989125Dynamic proteomics of nucleus accumbens in response to acute psychological stress in environmentally enriched and isolated rats
Q61473641E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking
Q58792105Early-life adversity selectively impairs α2-GABA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine
Q34237288Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment
Q34711395Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell.
Q36323513Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior.
Q89099639Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study
Q90369314Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Q102379198Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
Q26827394Epigenetic mechanisms in experience-driven memory formation and behavior
Q26829156Epigenetics and psychostimulant addiction
Q87770855Epigenetics, behavior and early nicotine
Q37220050Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action.
Q28590100Essential role of poly(ADP-ribosyl)ation in cocaine action
Q37573042Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5.
Q36398915Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.
Q96233948Exposure to maternal depressive symptoms and growth in adolescent substance use: The mediating role of delay discounting
Q47933084Fibroblast Growth Factor 2 in the Dorsomedial Striatum Is a Novel Positive Regulator of Alcohol Consumption.
Q63433050Food addiction: a valid concept?
Q24609658Food reward, hyperphagia, and obesity
Q33738812Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration
Q39301735From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms
Q35686543Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction
Q30454318Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses
Q64092426Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs
Q39052223Glutamate and Brain Glutaminases in Drug Addiction.
Q57473358Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
Q36772392Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration
Q36593944High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy
Q35605340Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.
Q34537418Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
Q37832749Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction
Q26995678Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction
Q36433035How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction
Q36453517Importance of cholesterol in dopamine transporter function
Q100465301Improving translation of animal models of addiction and relapse by reverse translation
Q40973001In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens.
Q34511728In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward
Q37712514Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.
Q92376205Inhibition of FGF Receptor-1 Suppresses Alcohol Consumption: Role of PI3 Kinase Signaling in Dorsomedial Striatum
Q42006918Inhibition of PKC disrupts addiction-related memory.
Q30440345Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats
Q36407360Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains
Q37968615Insights to drug addiction derived from ultrastructural views of the mesocorticolimbic system
Q35779290Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence
Q34029003Integrating synaptic plasticity and striatal circuit function in addiction
Q50103837Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine
Q49939866Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain
Q35558426IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
Q37032461Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
Q39885945Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal.
Q48113066Levodopa treatment and dendritic spine pathology
Q27002626Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?
Q47299450Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats.
Q47409991Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity
Q47969369Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex.
Q63979963Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking
Q30556607Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving
Q28389962Mechanisms of psychostimulant-induced structural plasticity
Q27003300Mechanisms of transgenerational inheritance of addictive-like behaviors
Q36912467Mediating the effects of drug abuse: the role of Narp in synaptic plasticity
Q47303917Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors.
Q34982877Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus
Q45340134Methods for treating neurological conditions (WO2011159945).
Q34538386Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference
Q36723555MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1.
Q30409196MicroRNAs in addiction: adaptation's middlemen?
Q90718508Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems
Q92329784Molecular Plasticity of the Nucleus Accumbens Revisited-Astrocytic Waves Shall Rise
Q38259368Molecular basis of alcoholism
Q89326887Molecular windows into the human brain for psychiatric disorders
Q92535551Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens
Q41143885Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis
Q92625031Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward
Q41654835Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons
Q48462251Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity
Q35046489Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.
Q35911131Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes
Q38435406NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.
Q48289374NMDA receptors in the midbrain play a critical role in dopamine-mediated hippocampal synaptic potentiation caused by morphine
Q22251254Natural rewards, neuroplasticity, and non-drug addictions
Q38220754Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction
Q100526330Neural mechanisms of aggression across species
Q39270688Neurobiology: a molecular knife to dice depression
Q97884787Neuronal Signaling: an introduction
Q36451816Neuronal correlates of depression.
Q21183972New insights into the roles of microRNAs in drug addiction and neuroplasticity
Q35333393New medications for drug addiction hiding in glutamatergic neuroplasticity
Q27007069New technologies for examining the role of neuronal ensembles in drug addiction and fear
Q36672602NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity
Q34363829Nuclear calcium signalling in the regulation of brain function
Q33974906Nucleus accumbens neuronal activity correlates to the animal's behavioral response to acute and chronic methylphenidate
Q96953338One Is Not Enough: Understanding and Modeling Polysubstance Use
Q37039781Opiate versus psychostimulant addiction: the differences do matter
Q38023866Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons
Q50023605Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling
Q35625766Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action
Q29346962Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Q35558068Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior
Q38233865Orquestic regulation of neurotransmitters on reward-seeking behavior.
Q55434407Oxycodone Self-Administration Induces Alterations in Expression of Integrin, Semaphorin and Ephrin Genes in the Mouse Striatum.
Q26853506Oxytocin and dendrite remodeling in the hypothalamus
Q90316009Parcellation of the striatal complex into dorsal and ventral districts
Q33923667Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function
Q89905655Pharmacotherapeutic management of co-morbid alcohol and opioid use
Q48206967Pre-synaptic dopamine D(3) receptor mediates cocaine-induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways
Q37642431Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking
Q36717666Prolonged Consumption of Sucrose in a Binge-Like Manner, Alters the Morphology of Medium Spiny Neurons in the Nucleus Accumbens Shell
Q55514796Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict.
Q41904036Prolonged withdrawal following cocaine self-administration increases resistance to punishment in a cocaine binge
Q42777637Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
Q64114752Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1
Q28478907Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats
Q36590613Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Q26999059Rapid, transient synaptic plasticity in addiction
Q50711696Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration.
Q38420812Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum
Q37576366Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum
Q58700126Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA
Q39190673Reward Circuitry in Addiction
Q33611438Reward Network Immediate Early Gene Expression in Mood Disorders
Q59292055Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Q30462673Reward processing in autism: a thematic series
Q39832885Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour.
Q47380696Role of Wnt/β-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity: a possible novel target for addiction treatment.
Q27011348Roles of the ubiquitin proteasome system in the effects of drugs of abuse
Q59899903Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum
Q34485446Sex differences in drug addiction and response to exercise intervention: From human to animal studies
Q47602986Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats
Q64911753Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress.
Q35195400Signalling pathways underlying structural plasticity of dendritic spines
Q26269816Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms
Q39295360Small molecule screening identifies regulators of the transcription factor ΔFosB
Q36379483Social influences on neuroplasticity: stress and interventions to promote well-being
Q35688907Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens
Q26768226Striatal Circuits as a Common Node for Autism Pathophysiology
Q90400892Structural Plasticity on the SpiNNaker Many-Core Neuromorphic System
Q33682148Structural alterations in the prefrontal cortex mediate the relationship between Internet gaming disorder and depressed mood
Q38937200Structural and functional plasticity of dendritic spines - root or result of behavior?
Q26866209Structural and synaptic plasticity in stress-related disorders
Q92899657Structural brain characteristics of anabolic-androgenic steroid dependence in men
Q38287920Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine.
Q37702707Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens
Q28266784Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens
Q30561321Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research
Q50026534Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.
Q92049925Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration
Q47299273Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Q38192648Synaptic changes induced by melanocortin signalling.
Q27005718Synaptic circuit remodelling by matrix metalloproteinases in health and disease
Q34559999Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.
Q37040227Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system.
Q58694142Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio
Q35514280Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
Q38261007The "addicted" spine
Q26864858The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond
Q34109551The Bermuda Triangle of cocaine-induced neuroadaptations
Q26798096The Brain on Drugs: From Reward to Addiction
Q36578522The HIV-1 transgenic rat model of neuroHIV.
Q37062547The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
Q47667543The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Q35235813The dark side of emotion: the addiction perspective
Q52093332The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling.
Q39431132The dopamine hypothesis of drug addiction and its potential therapeutic value
Q49108941The effects of an Echinacea preparation on synaptic transmission and the firing properties of CA1 pyramidal cells in the hippocampus
Q36068957The evolving role of dendritic spines and memory: Interaction(s) with estradiol
Q37195850The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine.
Q38879815The good and bad news about glutamate in drug addiction.
Q28088471The influence of stress and gonadal hormones on neuronal structure and function
Q48722025The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization
Q38222677The neural rejuvenation hypothesis of cocaine addiction
Q36744230The neurobiology of food intake in an obesogenic environment
Q36444223The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors
Q37910746The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
Q36610043The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior
Q36108828The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction
Q33771996The α1 Antagonist Doxazosin Alters the Behavioral Effects of Cocaine in Rats
Q50331928Tipping the Scales Toward Addiction.
Q51250494Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons.
Q22251017Transcriptional and epigenetic mechanisms of addiction
Q95592005Transcriptional mechanisms of drug addiction
Q22241120Transcriptional mechanisms of drug addiction
Q55399084Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen.
Q28538088Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization
Q101409823Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances
Q90426529Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity
Q35745420Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity
Q36456883Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking
Q34190564Up-regulation of microRNAs in brain of human alcoholics
Q36403790Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward
Q35593880Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction
Q26864720Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders
Q47811667Visualizing an emotional valence map in the limbic forebrain by TAI-FISH.
Q42321747WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine
Q34368812Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines
Q35574934Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia
Q59791835mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward
Q38199194mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse
Q90629625microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens
Q37490147ΔJunD overexpression in the nucleus accumbens prevents sexual reward in female Syrian hamsters
Q36583091∆FosB differentially modulates nucleus accumbens direct and indirect pathway function.

Search more.