Molecular basis of alcoholism

scientific article

Molecular basis of alcoholism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/B978-0-444-62619-6.00006-9
P932PMC publication ID4280079
P698PubMed publication ID25307570
P5875ResearchGate publication ID266949782

P2093author name stringR Adron Harris
Laura Ferguson
Dana Most
P2860cites workGenesis of alcohol-induced craniofacial dysmorphismQ36163328
Alcohol teratogenesis: mechanisms of damage and strategies for interventionQ36163342
Major histocompatibility complex class I proteins in brain development and plasticity.Q36384439
Effect of repeated treatment with topiramate on voluntary alcohol intake and beta-endorphin plasma level in Warsaw alcohol high-preferring ratsQ36508299
Induction of innate immune genes in brain create the neurobiology of addictionQ36554730
Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.Q36582066
Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependenceQ36587882
Alcohol-related genes: contributions from studies with genetically engineered miceQ36589451
The Effects of Drugs on Membrane FluidityQ36598983
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatmentQ36638579
Alcoholism: A Systems Approach From Molecular Physiology to Addictive BehaviorQ22241964
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and MemoryQ22241980
Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdalaQ24289260
DeltaFosB: a sustained molecular switch for addictionQ24555194
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
From inflammation to sickness and depression: when the immune system subjugates the brainQ24633527
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153Q24633965
FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholicsQ24642323
Epigenetic mechanisms in drug addictionQ24645709
Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcoholQ24646484
Neurocircuitry of addictionQ24647156
Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidenceQ24677018
Aripiprazole, alcohol and substance abuse: a reviewQ26866003
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channelQ27677407
Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brainQ28190023
A central role of the BK potassium channel in behavioral responses to ethanol in C. elegansQ28191512
Genetic polymorphisms of alcohol metabolizing enzymesQ28213908
Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of actionQ28257222
Increased brain uptake and oxidation of acetate in heavy drinkersQ36733426
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusionQ36756418
New applications of old metal-binding drugs in the treatment of human cancerQ36822739
Overview: how is alcohol metabolized by the body?Q36918858
Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actionsQ36952480
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcoholQ36970958
Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortexQ37087906
Acamprosate for the treatment of alcohol dependence: a review of double-blind, placebo-controlled trials.Q37093531
GABA(A) receptors and alcoholQ37142602
Ethanol's molecular targetsQ37165668
Putative role of brain acetaldehyde in ethanol addictionQ37362242
Epigenetics-beyond the genome in alcoholismQ37386414
The regulation of neuronal gene expression by alcohol.Q37603518
BK Channels: mediators and models for alcohol toleranceQ37603559
Role of the GABA(B) receptor in alcohol-seeking and drinking behaviorQ37632745
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolutionQ37890000
The development of medications for alcohol-use disorders targeting the GABAB receptor systemQ38009050
Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?Q38032481
The role of the innate immune system in psychiatric disordersQ38051988
Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.Q38407349
Candidate genes and their regulatory elements: alcohol preference and tolerance.Q38518216
Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory ratsQ39284448
Effects of alcohol on gene expression in neural cellsQ40672286
Lipid vs protein theories of alcohol action in the nervous systemQ41048126
Alcohols potentiate ion current mediated by recombinant 5-HT3RA receptors expressed in a mammalian cell lineQ41422021
The perturbation of lipid bilayers by general anesthetics: a quantitative test of the disordered lipid hypothesis.Q41645790
Effects of ondansetron administration on opioid withdrawal syndrome observed in ratsQ42543676
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damageQ43016846
Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in miceQ43116480
Role of dopamine D1 receptors and extracellular signal regulated kinase in the motivational properties of acetaldehyde as assessed by place preference conditioningQ43183837
Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neuronsQ43261575
Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbensQ43915028
Rapid suppression of alcohol withdrawal syndrome by baclofen.Q43917172
Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled studyQ44129398
Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary studyQ44245935
Alcohol intake after serotonin transporter inactivation in miceQ44483197
Neurokinin 1 receptor antagonism as a possible therapy for alcoholismQ28268781
The neuroimmune system in Alzheimer's disease: the glass is half fullQ28270052
Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytesQ28280597
Acamprosate produces its anti-relapse effects via calciumQ28299533
Alcoholism and inflammation: neuroimmunology of behavioral and mood disordersQ28302013
Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel stateQ28379420
Drug-induced epigenetic changes produce drug toleranceQ28469326
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionQ28506296
alpha-Synuclein produces a long-lasting increase in neurotransmitter releaseQ28510893
High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependenceQ28568437
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuliQ28591800
Effects of Acamprosate on Neuronal Receptors and Ion Channels Expressed inXenopusOocytesQ29030837
Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescenceQ29393461
A brain-specific microRNA regulates dendritic spine developmentQ29614753
Understanding alternative splicing: towards a cellular codeQ29615085
Epigenetic regulation in psychiatric disordersQ29616296
Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neuronsQ30311413
MicroRNAs in addiction: adaptation's middlemen?Q30409196
Effect of topiramate treatment on ethanol consumption in ratsQ30411198
Wild-type microglia arrest pathology in a mouse model of Rett syndromeQ30424614
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinkingQ30432894
Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialQ30446318
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.Q30453022
Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.Q30500334
Effects of chronic alcohol ingestion on the mesostriatal dopamine system in the rat.Q32025221
Synaptic regulation of translation of dendritic mRNAs.Q33342893
Molecular diversity of K+ channelsQ33691506
Intron 4 containing novel GABAB1 isoforms impair GABAB receptor functionQ33761327
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.Q33873827
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.Q33940362
Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL/6 mice.Q33940849
Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physicianQ33983758
Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in DrosophilaQ33991453
Understanding the health impact of alcohol dependenceQ34002624
Novel pharmacotherapeutic treatments for cocaine addictionQ34065088
Acamprosate and alcohol: II. Effects on alcohol withdrawal in the ratQ71546490
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine systemQ71681032
Mouse cerebellar GABAB participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 systemQ71710971
Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside GM1Q71776902
Ethanol effects in pigeons trained to discriminate MK-801, PCP or CGS-19755Q73553318
Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trialQ74177953
5-HT(3) receptor function and potentiation by alcohols in frontal cortex neurons from transgenic mice overexpressing the receptorQ74272010
Neurodegeneration and the neuroimmune systemQ82769587
How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.Q34073903
Disulfiram: an old therapeutic with new applicationsQ34101986
Effectiveness and safety of baclofen in the treatment of alcohol dependent patientsQ34101993
The splice of life: alternative splicing and neurological diseaseQ34186276
Up-regulation of microRNAs in brain of human alcoholicsQ34190564
Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trialQ34246904
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humansQ34277701
Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit compositionQ34297914
Gene expression induced by drugs of abuseQ34386430
Neuronal plasticity and cellular immunity: shared molecular mechanisms.Q34398085
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.Q34440513
Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.Q34458650
Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholismQ34561484
Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivationQ34565766
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.Q34597548
Serotonin and alcohol intake, abuse, and dependence: findings of animal studiesQ34722712
The use of antabus in the therapy of alcoholic patientsQ34852700
Emerging roles of PPARs in inflammation and immunityQ34931884
microRNAs at the synapseQ35011182
Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studiesQ35053308
microRNA-Seq reveals cocaine-regulated expression of striatal microRNAsQ35157752
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.Q35332004
Comparison of alcoholism subtypes as moderators of the response to sertraline treatmentQ35605831
Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulationQ35606143
MHCI negatively regulates synapse density during the establishment of cortical connections.Q35652867
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaineQ35676822
NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration.Q35735669
Understanding Alcoholism Through microRNA Signatures in Brains of Human AlcoholicsQ35878186
The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.Q35888462
5-HT and alcohol abuseQ35992700
Epigenetic mechanisms in memory formation.Q36011654
Serotonin's role in alcohol's effects on the brain.Q36037118
The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studiesQ36121404
Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbensQ36157695
Alcohol promotes dopamine release in the human nucleus accumbensQ44492239
Genetic strategies to detect genes involved in alcoholism and alcohol-related traits.Q44521730
Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.Q44561648
Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) ratsQ44654088
Ethanol sensitivity of recombinant homomeric and heteromeric AMPA receptor subunits expressed in Xenopus oocytesQ44703417
The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysisQ44743703
Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol seld-administrationQ44832756
Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons.Q44903537
Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cellsQ45219211
DNA hypermethylation of the alpha synuclein promoter in patients with alcoholismQ45239060
Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairmentQ46050079
Ethanol enhances GABAB-mediated inhibitory postsynaptic transmission on rat midbrain dopaminergic neurons by facilitating GIRK currentsQ46077299
Potential role of cAMP response element-binding protein in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene transcription in fetal mouse cortical cellsQ46387499
Alpha-synuclein protein levels are increased in alcoholic patients and are linked to cravingQ46493884
Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent mannerQ46644002
Brain chromatin remodeling: a novel mechanism of alcoholism.Q46667140
Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administrationQ46688805
Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individualsQ46808090
Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neuronsQ46824374
Alcohol regulates gene expression in neurons via activation of heat shock factor 1.Q46886452
DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction.Q46979963
Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanolQ47957533
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo LocusQ48215777
The effect of doxycycline on alcohol consumption and sensitivity: consideration for inducible transgenic mouse modelsQ48220938
Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats.Q48281442
Chronic ethanol consumption: from neuroadaptation to neurodegenerationQ48375308
The role of GABA(A) receptors in the acute and chronic effects of ethanolQ48378043
Efficacy and safety of aripiprazole in alcohol dependence.Q48393909
The epigenotype. 1942.Q48429495
Suppressing addiction using high-dose baclofen, rather than perpetuating it using substitution therapyQ48460443
Acute and Chronic Ethanol Exposure Alters the Function of Hippocampal Kainate Receptors Expressed in Xenopus OocytesQ48504594
Effects of acute and chronic ethanol treatment on pre- and postsynaptic responses to baclofen in rat hippocampusQ48653244
Expression of the alpha 1, alpha 2 and alpha 3 isoforms of the GABAA receptor in human alcoholic brainQ48765565
Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptorsQ48937190
Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus.Q48974772
Alteration of alcohol drinking in the rat by peripherally self-administered acetaldehydeQ49018091
Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: role of calcium and protein kinase C.Q49060395
Gene expression in human alcoholism: microarray analysis of frontal cortexQ49113773
Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of ratsQ49120676
Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics.Q51098151
Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockade: a preliminary study in healthy male volunteers.Q51146628
Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.Q51890058
Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence.Q52024450
Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat.Q52201096
GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats.Q52206021
Specific decreases in ethanol- but not water-reinforced responding produced by the 5-HT3 antagonist ICS 205-930.Q52225192
Epigenetic mechanisms: targets for treatment of alcohol dependence and drug addiction.Q52300636
Ethanol inhibits NMDA-activated ion current in hippocampal neuronsQ56226684
Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the ratQ59544956
Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neuronsQ67697982
MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring ratsQ67954967
P921main subjectalcoholismQ15326
P304page(s)89-111
P577publication date2014-01-01
P1433published inHandbook of clinical neurology / edited by P.J. Vinken and G.W. BruynQ26842295
P1476titleMolecular basis of alcoholism
P478volume125

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cites work (P2860)
Q50421147Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol
Q38438680Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice.
Q35805933Colour Vision Impairment in Young Alcohol Consumers
Q91133856Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster
Q58088316Educational and sport factors as predictors of harmful alcohol drinking in adolescence: a prospective study in Bosnia and Herzegovina
Q42375724Effects of acute alcohol ingestion on eye movements and cognition: A double-blind, placebo-controlled study
Q52316006From gene networks to drugs: systems pharmacology approaches for AUD.
Q52316042Innate Immune Signaling and Alcohol Use Disorders.
Q36674162Label-Free Proteomic Analysis of Protein Changes in the Striatum during Chronic Ethanol Use and Early Withdrawal
Q47875060Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain
Q60956688Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats
Q64886419Prehabilitation in Alcohol Dependence as a Treatment Model for Sustainable Outcomes. A Narrative Review of Literature on the Risks Associated With Detoxification, From Animal Models to Human Translational Research.
Q47560351When the brain changes its mind: Oscillatory dynamics of conflict processing and response switching in a flanker task during alcohol challenge

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