Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

scientific article published on 5 June 2015

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction is …
instance of (P31):
scholarly articleQ13442814

External links are
P8978DBLP publication IDjournals/bmcsb/Reyes-GibbyYWYS15
P356DOI10.1186/S12918-015-0167-X
P932PMC publication ID4456775
P698PubMed publication ID26044620
P5875ResearchGate publication ID277801597

P2093author name stringJian Wang
Sai-Ching J Yeung
Sanjay Shete
Cielito C Reyes-Gibby
Christine Yuan
P2860cites workThe association between smoking and subsequent repeated use of prescribed opioids among adolescents and young adults--a population-based cohort studyQ83015207
A genetic variant in the microRNA-146a gene is associated with susceptibility to alcohol use disordersQ87445612
Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adultsQ21283784
NCK2 is significantly associated with opiates addiction in African-origin menQ21284775
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom countsQ24605983
Associations among GABRG1, level of response to alcohol, and drinking behaviorsQ24622050
Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderly JapaneseQ28264804
Genes and (common) pathways underlying drug addictionQ28471939
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addictionQ28473095
Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data.Q30384423
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populationsQ30405502
New insights into the genetics of addictionQ30435949
A haplotype of the DRD1 gene is associated with alcohol dependence.Q46701438
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Q46881158
Rapid-onset opioids for the treatment of breakthrough cancer pain: two cases of drug abuse.Q47851937
Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smokingQ48329466
Association of neurexin 3 polymorphisms with smoking behaviorQ48466433
Metabolomic and network analysis of pharmacotherapies for sensorineural hearing lossQ50356159
Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers.Q50523231
Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine.Q51907944
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.Q51920093
Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study.Q52296857
Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations.Q52299302
A DRD2 and ANKK1 haplotype is associated with nicotine dependence.Q52300431
Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).Q52300996
DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy.Q52301002
Immunosuppressive agent modulates the severity of opiate withdrawalQ67951005
A118G mu opioid receptor polymorphism among drug addicts in MalaysiaQ44334798
BDNF variability in opioid addicts and response to methadone treatment: preliminary findings.Q44337437
Addictive behaviors related to opioid use for chronic pain: a population-based studyQ44340515
Dopamine receptor D4 gene -521C/T polymorphism is associated with opioid dependence through cold-pain responsesQ44340593
An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese populationQ44341978
Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addictionQ44342438
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.Q44840053
Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.Q45930766
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitutionQ46047802
Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A.Q46233600
Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, CanadaQ46325000
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.Q46477695
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyQ46594088
Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers.Q46694313
Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15Q30437542
Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.Q30445824
Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescentsQ33323373
The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addictionQ33579769
Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence familiesQ33595631
GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependenceQ33691260
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol DependenceQ33750970
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin womenQ33813262
Association of the HTR2A gene with alcohol and heroin abuseQ33859487
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.Q33940362
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependenceQ33942306
A polymorphism of the CREB binding protein (CREBBP) gene is a risk factor for addictionQ34027653
Opioid activation of toll-like receptor 4 contributes to drug reinforcementQ34294203
Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trialQ34336573
Development of allosteric modulators of GPCRs for treatment of CNS disordersQ34373958
Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependenceQ34414342
GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulatorsQ34426765
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependenceQ34556213
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestryQ34632811
The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobaccoQ34720978
Altering physiological networks using drugs: steps towards personalized physiologyQ34790013
Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian populationQ34873948
Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addictionQ34970338
Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control studyQ35005588
Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotypeQ35047668
Exploring drug-target interaction networks of illicit drugsQ35051482
Undocumented alcoholism and its correlation with tobacco and illegal drug use in advanced cancer patientsQ35082479
Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer riskQ35202104
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependenceQ35237992
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traitsQ35972927
Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction.Q35990231
CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies resultsQ36188181
Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patientsQ36625873
Case-control association study of WLS variants in opioid and cocaine addicted populations.Q36881320
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependenceQ36950936
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smokingQ36971373
CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addictionQ37075089
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53Q37118110
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine DependenceQ37121556
Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescentsQ37172778
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in NorwayQ37235138
Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypesQ37236484
Cannabinoid receptor 1 gene association with nicotine dependenceQ37322610
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependenceQ37369050
Why is neuroimmunopharmacology crucial for the future of addiction research?Q37381509
Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse.Q37381783
The brain reward circuitry in mood disordersQ37401710
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependenceQ37463998
Effect of the TaqIA polymorphism on ethanol response in the brainQ37484409
Symptom clusters of pain, depressed mood, and fatigue in lung cancer: assessing the role of cytokine genesQ37582383
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European AmericansQ37699515
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathwaysQ37711041
The CHRNA5-A3-B4 gene cluster in nicotine addictionQ37942053
Therapeutic potential of GABA(B) receptor ligands in drug addiction, anxiety, depression and other CNS disorders.Q38122963
Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.Q38177261
Extracellular signal-regulated protein kinases 1 and 2 activation by addictive drugs: a signal toward pathological adaptationQ38213139
Synaptic NF-kappa B pathway in neuronal plasticity and memoryQ38214046
Opioid management of pain: the impact of the prescription opioid abuse epidemicQ38227303
Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic TargetingQ38227885
Emerging role of CaMKII in neuropsychiatric disease.Q38236391
Genetic analysis of drug addiction: the role of cAMP response element binding proteinQ40866875
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine releaseQ41902714
Translational Bioinformatics Approaches to Drug DevelopmentQ42922307
Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severityQ42931523
Nicotine dependence predicts repeated use of prescribed opioids. Prospective population-based cohort studyQ42971443
Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramineQ43136215
Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: family and case control studyQ43144849
Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addictionQ43247971
Risk stratification of opioid misuse among patients with cancer pain using the SOAPP-SF.Q43868366
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addictionQ43880373
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behaviorQ44022700
Opioid abuse in cancer pain: report of two cases and presentation of an algorithm of multidisciplinary care.Q44329828
Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian populationQ44331868
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)25
P577publication date2015-06-05
P1433published inBMC Systems BiologyQ4835949
P1476titleGene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction
P478volume9

Reverse relations

cites work (P2860)
Q47555162A prospective, longitudinal study to evaluate the clinical utility of a predictive algorithm that detects risk of opioid use disorder
Q95642693Bi-directional Acceleration of Alcohol Use and Opioid Use Disorder
Q27317721Dietary intake alters gene expression in colon tissue: possible underlying mechanism for the influence of diet on disease
Q37472712Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content
Q92966149Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence
Q33874148Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis
Q38761790Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype
Q46465597Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer
Q35922750MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients
Q92104827Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis
Q91844097Underage drinking, alcohol dependence, and young people starting to use prescription pain relievers extra-medically: A zero-inflated Poisson regression model
Q41544475Validation Study of a Predictive Algorithm to Evaluate Opioid Use Disorder in a Primary Care Setting

Search more.