Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice

scientific article

Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1025171718
P356DOI10.1186/S40478-014-0147-1
P932PMC publication ID4236452
P698PubMed publication ID25384568
P5875ResearchGate publication ID268228258

P50authorMara Dierssen SotosQ11935056
Maria Victoria Sanchez-VivesQ21264343
Thomas GenerQ57453383
P2093author name stringMairena Martín
Inmaculada Ballesteros-Yáñez
Susanna Molas
Jofre Güell
P2860cites workWhy do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive functionQ24309129
Nicotine addictionQ24626554
Mammalian nicotinic acetylcholine receptors: from structure to functionQ24647069
The genetics of substance dependenceQ27002251
Molecular mechanisms of dendrite stabilityQ27015653
From men to mice: CHRNA5/CHRNA3, smoking behavior and diseaseQ27021102
Nicotine, brain nicotinic receptors, and neuropsychiatric disordersQ28139928
Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient miceQ28506230
Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene familyQ28571860
Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout miceQ28594309
Dendritic spine pathology in neuropsychiatric disordersQ29615871
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disordersQ30435763
Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.Q30454907
Ultrastructural identification of entorhinal cortical synapses in CA1 stratum lacunosum-moleculare of the rat.Q30463951
Cognitive effects of nicotine: genetic moderatorsQ30474904
Nicotine and hippocampus-dependent learning: implications for addictionQ30488043
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learningQ30494493
Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in miceQ30495752
Working memory deficits predict short-term smoking resumption following brief abstinenceQ33625059
Nicotinic mechanisms influencing synaptic plasticity in the hippocampusQ33830478
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens.Q33940362
Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptorsQ33953018
Addiction: a disease of learning and memoryQ33989062
A genetically modulated, intrinsic cingulate circuit supports human nicotine addictionQ34068084
Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behaviorQ34304101
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptomsQ34385515
The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy.Q34419501
Synaptogenesis via dendritic filopodia in developing hippocampal area CA1.Q34476864
Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.Q34616154
Do thin spines learn to be mushroom spines that remember?Q34627910
Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibilityQ34660486
Habenular α5 nicotinic receptor subunit signalling controls nicotine intakeQ34816555
Plasticity of reward neurocircuitry and the 'dark side' of drug addictionQ46177203
Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer's aetiopathologyQ47704465
Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.Q47849557
Nicotinic receptor activation in perirhinal cortex and hippocampus enhances object memory in ratsQ48013480
Mapping the location of functional nicotinic and gamma-aminobutyric acidA receptors on hippocampal neurons.Q48850112
Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.Q52299798
Nicotine dependence and tolerance in man: pharmacokinetic and pharmacodynamic investigationsQ69389545
Cellular and synaptic mechanisms of nicotine addictionQ35000325
Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticityQ35100692
The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J miceQ35179522
Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunitsQ35619422
Extrinsic and local glutamatergic inputs of the rat hippocampal CA1 area differentially innervate pyramidal cells and interneurons.Q35757282
Structural plasticity associated with exposure to drugs of abuseQ35908693
Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of miceQ35946508
Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptorsQ36018428
Induction of dendritic spines by β2-containing nicotinic receptors.Q36070659
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictionsQ36137598
Nicotinic ACh receptors in the hippocampus: role in excitability and plasticityQ36349953
Effects of chronic network hyperexcitability on the growth of hippocampal dendritesQ36482369
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsQ36501908
Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divideQ36581474
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.Q36763267
Variants in nicotinic receptors and risk for nicotine dependenceQ36952598
Balancing structure and function at hippocampal dendritic spinesQ37088448
Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval.Q37171360
Medial habenula output circuit mediated by α5 nicotinic receptor-expressing GABAergic neurons in the interpeduncular nucleusQ37309505
Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthoodQ37419196
Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.Q37561567
Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systemsQ38122913
Short-term synaptic plasticityQ38613257
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.Q39545781
Acute and chronic nicotine exposure differentially facilitate the induction of LTP.Q41698390
Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region.Q41731213
CRMP3 is required for hippocampal CA1 dendritic organization and plasticity.Q41909986
Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from storesQ42172411
The occipitoparietal pathway of the macaque monkey: comparison of pyramidal cell morphology in layer III of functionally related cortical visual areas.Q42442917
Codistribution of nicotinic acetylcholine receptor subunit alpha3 and beta4 mRNAs during rat brain developmentQ42447442
Effects of gestational nicotine exposure on hippocampal morphologyQ42459536
Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acidQ42490274
Density and morphology of dendritic spines in mouse neocortex.Q42490404
Interlaminar differences in the pyramidal cell phenotype in cortical areas 7 m and STP (the superior temporal polysensory area) of the macaque monkeyQ42506177
Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performanceQ42872011
Nicotinic α5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neuronsQ42960464
Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortexQ43830124
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.Q44182704
Expression of alpha5 nicotinic acetylcholine receptor subunit mRNA during hippocampal and cortical developmentQ45159474
The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background.Q45355134
Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction.Q45934492
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P921main subjectoverexpressionQ61643320
P304page(s)147
P577publication date2014-11-11
P1433published inActa Neuropathologica CommunicationsQ27724912
P1476titleHippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
P478volume2

Reverse relations

cites work (P2860)
Q92321680Brain Ageing, Cognition and Diet: A Review of the Emerging Roles of Food-Based Nootropics in Mitigating Age-related Memory Decline
Q30362464nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.

Search more.