Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease

scientific article published on 14 February 2012

Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3791/3234
P932PMC publication ID3376941
P698PubMed publication ID22370630

P2093author name stringJoanne E Nash
Ruth Warre
Sherri L Thiele
P2860cites workParkinson's disease: mechanisms and modelsQ29547424
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
Dichotomous dopaminergic control of striatal synaptic plasticityQ30493521
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in miceQ33215982
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's diseaseQ33596638
Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease.Q33817654
Behavioral phenotyping of the MPTP mouse model of Parkinson's diseaseQ34420632
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates.Q35969693
Novel approaches to the symptomatic treatment of parkinsonian syndromes: alternatives and adjuncts to dopamine-replacementQ41573347
Unilateral lesion of the nigrostriatal pathway decreases the firing rate and alters the firing pattern of globus pallidus neurons in the rat.Q42000019
A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal functionQ42463405
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Characterization of a rodent model in which to investigate the molecular and cellular mechanisms underlying the pathophysiology of L-dopa-induced dyskinesiaQ42539453
Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neuronsQ42682549
MPTP-induced models of Parkinson's disease in mice and non-human primatesQ42726539
Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundleQ43538536
Differential neuronal activity in segments of globus pallidus in Parkinson's disease patientsQ48087749
On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidusQ48194684
Non-specific supersensitivity of striatal dopamine receptors after 6-hydroxydopamine lesion of the nigrostriatal pathwayQ48405151
Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry studyQ48666967
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.Q48876521
Metabolism of tyramine-3H and octopamine-3H by rat brainQ49045775
Glutamate induces calcium waves in cultured astrocytes: long-range glial signalingQ49130167
Generation of a model of L-DOPA-induced dyskinesia in two different mouse strains.Q50526050
On the altered expression of tyrosine hydroxylase and calbindin-D 28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat.Q54047216
Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanismsQ69754343
[3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: delineation of striosomal compartments and pallidal and nigral subdivisionsQ69924137
Priming of a D1 dopamine receptor behavioural response is dissociated from striatal immediate-early gene activityQ71525171
CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injuryQ73503153
P433issue60
P921main subjectParkinson's diseaseQ11085
P577publication date2012-02-14
P1433published inJournal of Visualized ExperimentsQ954500
P1476titleDevelopment of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease

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cites work (P2860)
Q481964266-OHDA-Lesioned Adult Zebrafish as a Useful Parkinson's Disease Model for Dopaminergic Neuroregeneration
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