| scholarly article | Q13442814 |
| P356 | DOI | 10.1093/HMG/DDU543 |
| P698 | PubMed publication ID | 25343991 |
| P4011 | Semantic Scholar paper ID | d7c8de79306883f1be34a56ee3a734c21371dc12 |
| P50 | author | Dayne A Beccano-Kelly | Q48543606 |
| Mattia Volta | Q58567856 | ||
| Igor Tatarnikov | Q59108657 | ||
| Heather L. Melrose | Q60042463 | ||
| Sarah A Paschall | Q63856938 | ||
| L.N. Munsie | Q67468770 | ||
| K. Co | Q67468808 | ||
| P. Chou | Q67468822 | ||
| L.P. Cao | Q67468834 | ||
| S. Bergeron | Q67468848 | ||
| Emma Mitchell | Q67468867 | ||
| H. Han | Q67468884 | ||
| L. Tapia | Q67468913 | ||
| A.J. Milnerwood | Q67468941 | ||
| Matthew J. Farrer | Q37380292 | ||
| Lynn A Raymond | Q39804644 | ||
| P2860 | cites work | LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool | Q24292798 |
| Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice | Q24293070 | ||
| LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis | Q24299176 | ||
| LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth | Q24304347 | ||
| A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation | Q24310126 | ||
| Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models | Q42508054 | ||
| Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons | Q44463501 | ||
| A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission | Q44853701 | ||
| Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load | Q45306738 | ||
| Pharmacological and genetic evidence for pre- and postsynaptic D2 receptor involvement in motor responses to nociceptin/orphanin FQ receptor ligands | Q45797407 | ||
| Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum. | Q46279749 | ||
| Parallel processing of environmental recognition and locomotion in the mouse striatum. | Q46968121 | ||
| LRRK2 expression is enriched in the striosomal compartment of mouse striatum | Q48422418 | ||
| Role of dopamine in the primate caudate nucleus in reward modulation of saccades. | Q48535179 | ||
| Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning. | Q52002708 | ||
| LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction | Q24316894 | ||
| The familial Parkinsonism gene LRRK2 regulates neurite process morphology | Q24317613 | ||
| Interplay of LRRK2 with chaperone-mediated autophagy | Q24322747 | ||
| LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity | Q24323196 | ||
| LRRK2 phosphorylates novel tau epitopes and promotes tauopathy | Q24338188 | ||
| Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β | Q24338942 | ||
| Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S | Q28589899 | ||
| LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity | Q29615144 | ||
| Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors | Q30450310 | ||
| Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. | Q30489765 | ||
| LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors | Q30524899 | ||
| Concurrent activation of striatal direct and indirect pathways during action initiation. | Q30579307 | ||
| Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease | Q33754793 | ||
| Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades | Q33762162 | ||
| Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice | Q34098463 | ||
| The neurobiology of slow synaptic transmission | Q34100272 | ||
| Retrograde signaling by endocannabinoids | Q34131853 | ||
| Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling | Q34650334 | ||
| Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities | Q35172817 | ||
| A comparative study of Lrrk2 function in primary neuronal cultures | Q35176338 | ||
| Dopaminergic modulation of synaptic transmission in cortex and striatum | Q35282100 | ||
| DARPP-32: an integrator of neurotransmission | Q35639141 | ||
| The basal ganglia: learning new tricks and loving it. | Q36306845 | ||
| The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease | Q36325701 | ||
| Modulation of striatal projection systems by dopamine | Q36367283 | ||
| Integrating neurotransmission in striatal medium spiny neurons. | Q37986667 | ||
| The synaptic function of LRRK2. | Q38044429 | ||
| Dopamine modulates release from corticostriatal terminals. | Q42469821 | ||
| Reliable long-lasting depression interacts with variable short-term facilitation to determine corticostriatal paired-pulse plasticity in young rats | Q42507036 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | dopamine | Q170304 |
| striatum | Q1319792 | ||
| overexpression | Q61643320 | ||
| P304 | page(s) | 1336-1349 | |
| P577 | publication date | 2014-10-24 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory | |
| P478 | volume | 24 |
| Q99711175 | A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2 |
| Q37701053 | Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice |
| Q37080018 | Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation |
| Q64769126 | An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2 |
| Q64881160 | Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum. |
| Q30356916 | Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. |
| Q37580673 | Changes in functional organization and white matter integrity in the connectome in Parkinson's disease |
| Q50055669 | Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease |
| Q38837604 | Early synaptic dysfunction in Parkinson's disease: Insights from animal models. |
| Q37660899 | Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons |
| Q38873613 | Epigenetic mechanisms in neurogenesis |
| Q37096048 | G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. |
| Q38795375 | Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice |
| Q48314575 | Impaired intracortical transmission in G2019S leucine rich-repeat kinase Parkinson patients |
| Q42268862 | Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice |
| Q38588014 | Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease |
| Q36581417 | LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function |
| Q92173150 | LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same |
| Q28267434 | Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain |
| Q64286295 | Leucine‐rich repeat kinase 2 ( LRRK 2) inhibitors differentially modulate glutamate release and Serine935 LRRK 2 phosphorylation in striatal and cerebrocortical synaptosomes |
| Q90326227 | Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype |
| Q48239635 | Mechanisms of Mutant LRRK2 Neurodegeneration |
| Q47147993 | Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease |
| Q39206443 | Models of LRRK2-Associated Parkinson's Disease |
| Q90359231 | Neurodegenerative diseases: model organisms, pathology and autophagy |
| Q96219413 | Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out |
| Q91790352 | Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits |
| Q37707932 | Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology |
| Q47222316 | PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2. |
| Q47621902 | Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. |
| Q100418590 | Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations |
| Q27308060 | Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice |
| Q38650395 | Review: Parkinson's disease: from synaptic loss to connectome dysfunction. |
| Q49545058 | Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice |
| Q33764887 | Role of LRRK2 in the regulation of dopamine receptor trafficking |
| Q35999331 | Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. |
| Q42342648 | Synapses in neurodegenerative diseases |
| Q92742934 | Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging |
| Q89983587 | The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant |
| Q35941370 | The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus |
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