Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.

scientific article published on November 2007

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1742-7843.2007.00130.X
P698PubMed publication ID17910610
P5875ResearchGate publication ID5933640

P50authorJarmo T LaitinenQ48131809
P2093author name stringSusanna M Saario
P2860cites workExpression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulationsQ24309438
N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivoQ24532188
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolaseQ24555807
2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptorQ24620096
Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitroQ24673383
Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranesQ24673517
Structural adaptations in a membrane enzyme that terminates endocannabinoid signalingQ27640068
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanismQ28138523
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptorsQ28185158
Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase geneQ28208449
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptorQ28218654
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
A second endogenous cannabinoid that modulates long-term potentiationQ28248073
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolaseQ46718450
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implicationsQ46731448
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid typQ46801175
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesiaQ46826807
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesiaQ46868894
Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat.Q48254078
Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolaseQ48634796
Isolation, Structure, and Partial Synthesis of an Active Constituent of HashishQ55871276
cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidasesQ28252158
A FAAH-regulated class of N-acyl taurines that activates TRP ion channelsQ28253967
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brainQ28259933
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampusQ28268567
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampusQ28286042
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compoundsQ28294909
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amidesQ28295481
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cellsQ28378272
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisQ34234907
Functional disassociation of the central and peripheral fatty acid amide signaling systemsQ34332678
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptorQ34358410
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidaseQ34385277
An endocannabinoid mechanism for stress-induced analgesia.Q34428429
A second fatty acid amide hydrolase with variable distribution among placental mammalsQ34570802
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerolQ35048362
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptorQ35048967
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain modelsQ35545219
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).Q36533477
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertensionQ37373710
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanismsQ38757749
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cellsQ40158906
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptorsQ40174517
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.Q40525710
Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophagesQ40935411
The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptorsQ41584525
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptorsQ41832173
The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamideQ42108464
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivoQ44028862
Possible endocannabinoid control of colorectal cancer growthQ44569526
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivityQ44903331
Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptorsQ44926114
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionalityQ44926848
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.Q45173372
Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levelsQ46553209
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medullaQ46675581
Fatty acid amide hydrolase controls mouse intestinal motility in vivoQ46687826
P433issue5
P921main subjectendocannabinoidsQ10483908
P304page(s)287-293
P577publication date2007-11-01
P1433published inBasic and Clinical Pharmacology and ToxicologyQ15724438
P1476titleTherapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors
P478volume101