Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

scientific article published on 05 September 2008

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1038/NM.F.1869
P698PubMed publication ID18776886
P5875ResearchGate publication ID23242821

P2093author name stringTamás F Freund
István Katona
P2860cites workCloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Cannabinoid receptor localization in brainQ24558751
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alphaQ24564778
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerolQ24649418
Cannabinoids control spasticity and tremor in a multiple sclerosis modelQ28138564
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Role of endogenous cannabinoids in synaptic signalingQ28185075
CB1 cannabinoid receptors and on-demand defense against excitotoxicityQ28207143
Leptin-regulated endocannabinoids are involved in maintaining food intakeQ28211969
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
A second endogenous cannabinoid that modulates long-term potentiationQ28248073
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampusQ28268567
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampusQ28286042
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Homer: a protein that selectively binds metabotropic glutamate receptorsQ28305877
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout miceQ28343324
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in miceQ28469322
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellumQ28587112
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptorsQ28587334
Phospholipase C isozymes selectively couple to specific neurotransmitter receptorsQ28593039
The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammationQ28594581
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
The molecular logic of endocannabinoid signallingQ29615356
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formationQ30478061
Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) programQ31144410
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortexQ33293523
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptorsQ44553567
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsyQ44572950
A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity.Q44898084
Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampusQ44927481
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens.Q45007590
Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.Q45138733
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.Q45163158
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.Q46624652
Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.Q46691853
Depolarization-induced suppression of excitation in murine autaptic hippocampal neuronesQ46716625
Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons.Q46767737
Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling.Q46793967
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout miceQ47994629
Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid releaseQ48094449
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticusQ48103150
Role of the cyclic-AMP/PKA cascade and of P/Q-type Ca++ channels in endocannabinoid-mediated long-term depression in the nucleus accumbens.Q48118951
Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamusQ48173430
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.Q48217036
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiographyQ48297848
Metabotropic suppression of excitation in murine autaptic hippocampal neuronsQ48367782
Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor.Q48556515
Coevolution between cannabinoid receptors and endocannabinoid ligands.Q51913519
CB1-cannabinoid receptors are involved in the modulation of non-synaptic [3H]serotonin release from the rat hippocampus.Q54579193
CB1 cannabinoid receptors are enriched in the perisynaptic annulus and on preterminal segments of hippocampal GABAergic axonsQ60155175
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cellsQ61479730
Activation of the endocannabinoid system by organophosphorus nerve agentsQ34011342
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbensQ34032832
An endogenous cannabinoid (2-AG) is neuroprotective after brain injuryQ34093755
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisQ34234907
An endocannabinoid mechanism for stress-induced analgesia.Q34428429
Involvement of the endocannabinoid system in drug addictionQ34495242
Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligandQ34522513
Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels.Q34548706
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotectionQ34597537
Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signalingQ34650334
Molecular composition of the endocannabinoid system at glutamatergic synapses.Q35220762
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain modelsQ35545219
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectorsQ35749646
On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizuresQ35903023
Pharmacological actions of cannabinoids.Q36441175
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptorsQ36447081
Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area.Q36452302
Endocannabinoid-mediated synaptic plasticity in the CNS.Q36507561
Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurinQ36786835
P2X7 receptors control 2-arachidonoylglycerol production by microglial cellsQ36854779
A neuroscientist's guide to lipidomics.Q36946556
Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic painQ36997712
Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapsesQ37288785
Presynaptic specificity of endocannabinoid signaling in the hippocampusQ39750122
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampusQ39757955
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.Q40116679
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.Q40525710
Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortexQ41905626
The endocannabinoid system controls key epileptogenic circuits in the hippocampusQ42065383
CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of actionQ42498502
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatumQ42523780
Integration of endocannabinoid and leptin signaling in an appetite-related neural circuitQ43095188
Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.Q43570628
Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminalsQ43574291
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptorsQ43715218
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumQ43971441
Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severityQ44164051
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitabilityQ44437517
Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism.Q44495434
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectendocannabinoidsQ10483908
P304page(s)923-930
P577publication date2008-09-05
P1433published inNature MedicineQ1633234
P1476titleEndocannabinoid signaling as a synaptic circuit breaker in neurological disease
P478volume14

Reverse relations

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Q47742909Synergistic interaction of the cannabinoid and death receptor systems - a potential target for future cancer therapies?
Q39876164Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol
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Q50226059The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction.
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Q37522883The cannabinoid CB₂ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis
Q48318429The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels.
Q38669685The cannabinoid system and pain
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Q38220568The endocannabinoid system and appetite: relevance for food reward
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Q30471032The endocannabinoid system in anxiety, fear memory and habituation
Q48089129The endocannabinoid system in rat gliosomes and its role in the modulation of glutamate release.
Q35070299The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys
Q33525520The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas
Q89881678The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake
Q34949720The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica
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Q38606080The potential role of cannabinoids in epilepsy treatment
Q37913717The role of the endocannabinoid system in the neuroendocrine regulation of energy balance.
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Q26859198The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
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Q37381132Trajectory of adolescent cannabis use on addiction vulnerability
Q50933412Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study.
Q42948746Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism
Q34571086Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells
Q28585288Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
Q34582789Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus
Q47566341Using molecular imaging to understand early schizophrenia-related psychosis neurochemistry: a review of human studies.
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