Multiple functions of endocannabinoid signaling in the brain.

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Multiple functions of endocannabinoid signaling in the brain. is …
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scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-NEURO-062111-150420
P932PMC publication ID4273654
P698PubMed publication ID22524785

P50authorTamás FreundQ1003857
István KatonaQ38320341
P2860cites workHomer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 ReceptorsQ24295021
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Cannabinoid receptor localization in brainQ24558751
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effectsQ24569799
Activity-dependent regulation of synapses by retrograde messengersQ24614596
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptorsQ24617322
Arachidonic acid and the brainQ24620380
DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptorsQ24644031
TRPV1 channels mediate long-term depression at synapses on hippocampal interneuronsQ24644177
Novel endogenous peptide agonists of cannabinoid receptorsQ24644673
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerolQ24649418
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acidQ24657423
A biosynthetic pathway for anandamideQ24671032
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptorQ24680848
Hemopressin is an inverse agonist of CB1 cannabinoid receptorsQ24683759
Understanding synapses: past, present, and futureQ26269897
Endocannabinoid signaling and long-term synaptic plasticity.Q35679432
Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneuronsQ36018163
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out miceQ36020820
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptorsQ36447081
Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area.Q36452302
Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleusQ36601711
COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticityQ36677473
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brainQ36727266
Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activityQ36734402
Homeostatic signaling: the positive side of negative feedbackQ36798818
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptorsQ36861457
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneuronsQ28144567
Molecular characterization of a phospholipase D generating anandamide and its congenersQ28186509
CB1 cannabinoid receptors and on-demand defense against excitotoxicityQ28207143
Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cellsQ28212245
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptorQ28218654
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
A second endogenous cannabinoid that modulates long-term potentiationQ28248073
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signalingQ28253698
Identification and functional characterization of brainstem cannabinoid CB2 receptorsQ28276972
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampusQ28286042
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amidesQ28295481
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂Q28298445
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in miceQ28469322
Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerolQ28511266
Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanismQ28571959
Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase DQ28581971
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1Q28582069
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellumQ28587112
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid systemQ28590486
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out miceQ28591248
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesisQ28591542
Phospholipase C isozymes selectively couple to specific neurotransmitter receptorsQ28593039
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmissionQ28594648
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Determination and characterization of a cannabinoid receptor in rat brainQ29618888
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formationQ30478061
Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitizationQ30484615
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.Q30492114
Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.Q30492857
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbensQ30500199
Role of CB1 cannabinoid receptors on GABAergic neurons in brain agingQ30502227
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampusQ36917918
Activation of GABAA receptors: views from outside the synaptic cleft.Q37022454
TRPC3 channels are required for synaptic transmission and motor coordinationQ37099115
Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia.Q37216017
Endocannabinoid signaling as a synaptic circuit breaker in neurological diseaseQ37262759
Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stressQ37276946
Transmembrane helical domain of the cannabinoid CB1 receptorQ37282203
Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptorsQ37285069
Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapsesQ37288785
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic painQ37312874
Diglyceride lipase: a pathway for arachidonate release from human plateletsQ37336055
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?Q37337607
Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuseQ37355904
Endocannabinoid-mediated control of synaptic transmissionQ37363621
Spine microdomains for postsynaptic signaling and plasticityQ37425885
Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons.Q37436040
Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission.Q39753711
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampusQ39757955
Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.Q39831177
Multiple pathways involved in the biosynthesis of anandamideQ40106992
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.Q40116679
A molecular basis of analgesic tolerance to cannabinoids.Q40146609
Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and functionQ40224903
Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cellsQ40773784
Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons.Q40818985
Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2.Q41093128
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathwayQ41791622
Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cellsQ41808335
The endocannabinoid system controls key epileptogenic circuits in the hippocampusQ42065383
The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneuronsQ42110966
Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brainQ42479973
Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.Q42528169
Endocannabinoids Potentiate Synaptic Transmission through Stimulation of AstrocytesQ42870301
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid systemQ42882543
Good news for CB1 receptors: endogenous agonists are in the right placeQ42986826
Bimodal control of stimulated food intake by the endocannabinoid system.Q43169799
Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cellsQ43182541
Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapsesQ43191478
Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoidsQ43251476
Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.Q43570628
Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminalsQ43574291
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptorsQ43715218
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.Q30606134
Drug discovery and natural products: end of an era or an endless frontier?Q30866998
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?Q33211909
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortexQ33293523
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid systemQ33323392
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.Q33716248
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticityQ33744346
AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicityQ33784846
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapsesQ33814760
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapsesQ33940688
Distinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampusQ33996513
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.Q34025536
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbensQ34032832
Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytesQ34048105
An endogenous cannabinoid (2-AG) is neuroprotective after brain injuryQ34093755
Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokersQ34199610
Brain cannabinoid CB₂ receptors modulate cocaine's actions in miceQ34203193
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisQ34234907
An endocannabinoid mechanism for stress-induced analgesia.Q34428429
Chemical constituents of marijuana: the complex mixture of natural cannabinoidsQ34455944
Spine Ca2+ signaling in spike-timing-dependent plasticity.Q34576681
Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleusQ34582789
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus.Q34684362
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.Q34691517
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liverQ34794697
Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanismsQ35080503
Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cellsQ35172234
Molecular composition of the endocannabinoid system at glutamatergic synapses.Q35220762
Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranesQ35592076
COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitationQ35593070
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.Q35678770
Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lungQ43812206
Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus.Q43816494
Postsynaptic endocannabinoid release is critical to long-term depression in the striatumQ43971441
2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brainQ44018878
The endogenous cannabinoid system controls extinction of aversive memoriesQ44085607
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitabilityQ44437517
n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in miceQ44524041
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channelsQ44524443
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptorsQ44553567
Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currentsQ44758240
Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampusQ44927481
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in miceQ45087565
The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling.Q45240196
U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance.Q45253911
Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivoQ45299326
Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus.Q46055962
Predominant expression of phospholipase Cbeta1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elementsQ46273270
Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cellsQ46366299
Presynaptic, activity-dependent modulation of cannabinoid type 1 receptor-mediated inhibition of GABA release.Q46366644
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.Q46624652
Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.Q46691853
Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids.Q46764070
Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cellsQ47681459
Lysophosphoinositide-specific phospholipase C in rat brain synaptic plasma membranesQ48146427
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.Q48217036
Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneuronsQ48240092
Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing.Q48279730
Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor.Q48556515
Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalizationQ48918978
Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortexQ48971057
Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signalQ49124925
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus.Q52023779
Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception.Q53577374
Glycine potentiates the NMDA response in cultured mouse brain neuronsQ59050531
Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampusQ59081310
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cellsQ61479730
A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brainQ64212085
The absolute configuration of δ1-tetrahydrocannabinol, the major active constituent of hashishQ72255583
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosisQ83389390
Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in ratsQ83523096
Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrusQ84197041
Chemical basis of hashish activityQ93803717
P921main subjectendocannabinoidsQ10483908
P304page(s)529-558
P577publication date2012-04-17
P1433published inAnnual Review of NeuroscienceQ15753632
P1476titleMultiple functions of endocannabinoid signaling in the brain
P478volume35