| P50 | author | Benjamin Cravatt | Q4888433 |
| P2093 | author name string | Kay Ahn | |
| | Douglas S Johnson | |
| P2860 | cites work | Development of highly sensitive fluorescent assays for fatty acid amide hydrolase | Q23913685 |
| | Molecular characterization of human and mouse fatty acid amide hydrolases | Q24317261 |
| | Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase | Q24555807 |
| | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | Q24569799 |
| | The endocannabinoid system as an emerging target of pharmacotherapy | Q24648473 |
| | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling | Q24658561 |
| | Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes | Q24680869 |
| | Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling | Q27640068 |
| | Structure-guided inhibitor design for human FAAH by interspecies active site conversion | Q27651822 |
| | Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain | Q27655121 |
| | Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism | Q28138523 |
| | Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage | Q28142608 |
| | Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity | Q28253977 |
| | Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist | Q28262546 |
| | Identification of a high-affinity binding site involved in the transport of endocannabinoids | Q28284073 |
| | Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies | Q28285285 |
| | The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome | Q28291178 |
| | Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides | Q28295481 |
| | The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice | Q28296777 |
| | Chemical characterization of a family of brain lipids that induce sleep | Q28302534 |
| | Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase | Q28305612 |
| | Enzymatic pathways that regulate endocannabinoid signaling in the nervous system | Q28390932 |
| | Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase | Q28570492 |
| | Isolation and structure of a brain constituent that binds to the cannabinoid receptor | Q29547476 |
| | The molecular logic of endocannabinoid signalling | Q29615356 |
| | Modulation of anxiety through blockade of anandamide hydrolysis | Q29615902 |
| | Discovering potent and selective reversible inhibitors of enzymes in complex proteomes | Q31141832 |
| | A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase | Q33262682 |
| | Genetic loss of Faah compromises male fertility in mice | Q33583700 |
| | A missense mutation in human fatty acid amide hydrolase associated with problem drug use. | Q34032872 |
| | The palmitoylethanolamide family: a new class of anti-inflammatory agents? | Q34123191 |
| | Properties of rat liver N-acylethanolamine amidohydrolase | Q34200418 |
| | Profiling serine hydrolase activities in complex proteomes | Q43573967 |
| | Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer | Q43871400 |
| | Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test | Q43950838 |
| | Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes | Q43979860 |
| | Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia | Q44902561 |
| | Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity | Q44903331 |
| | Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice | Q44922643 |
| | Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality | Q44926848 |
| | Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. | Q44963304 |
| | Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. | Q45173372 |
| | Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity | Q45266871 |
| | Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase | Q46190650 |
| | Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors | Q46204009 |
| | Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). | Q46421589 |
| | Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase | Q46436130 |
| | Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors | Q46584481 |
| | Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH). | Q46741641 |
| | Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling | Q46842278 |
| | Bidirectional cannabinoid modulation of social behavior in adolescent rats. | Q46867213 |
| | Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization | Q46897087 |
| | The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. | Q46907848 |
| | Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol | Q46943485 |
| | Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress | Q48163197 |
| | Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling | Q50113929 |
| | Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. | Q50890840 |
| | The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. | Q51907085 |
| | The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites | Q57730973 |
| | Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain | Q60679661 |
| | Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’ | Q60690647 |
| | The cannabinoid CB1receptor and the endocannabinoid anandamide: possible antidepressant targets | Q60710780 |
| | Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in Rats | Q61896991 |
| | A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain | Q64212085 |
| | Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide | Q71743278 |
| | Study of the amidase signature group | Q71938746 |
| | Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain | Q71988975 |
| | Inhibitors of arachidonoyl ethanolamide hydrolysis | Q72181445 |
| | Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization | Q72631582 |
| | Novel inhibitors of fatty acid amide hydrolase | Q80218012 |
| | Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists | Q81620167 |
| | Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. | Q34200866 |
| | Marihuana Chemistry | Q34222495 |
| | Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis | Q34234907 |
| | Functional disassociation of the central and peripheral fatty acid amide signaling systems | Q34332678 |
| | Biochemical mechanisms of drug action: what does it take for success? | Q34344862 |
| | An endocannabinoid mechanism for stress-induced analgesia. | Q34428429 |
| | Anandamide transport: a critical review. | Q34429012 |
| | The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications | Q34439965 |
| | Cannabinoid receptors as therapeutic targets. | Q34482964 |
| | Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand | Q34522513 |
| | The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases | Q34550883 |
| | A second fatty acid amide hydrolase with variable distribution among placental mammals | Q34570802 |
| | Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase | Q34573261 |
| | Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. | Q34872158 |
| | Fatty acid amide hydrolase deficiency limits early pregnancy events | Q34872765 |
| | A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation | Q35035844 |
| | Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors | Q35202878 |
| | Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system | Q35206939 |
| | Cellular accumulation of anandamide: consensus and controversy | Q35217244 |
| | Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models | Q35545219 |
| | Chemical strategies for activity-based proteomics | Q35616321 |
| | The development and application of methods for activity-based protein profiling | Q35703156 |
| | Critical enzymes involved in endocannabinoid metabolism | Q35924804 |
| | Recent advances in the medicinal chemistry of alpha-aminoboronic acids, amine-carboxyboranes and their derivatives | Q35950465 |
| | Structure and function of fatty acid amide hydrolase | Q36161171 |
| | Evaluation of fatty acid amides in the carrageenan-induced paw edema model | Q36384547 |
| | The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition | Q36404693 |
| | Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats | Q36426811 |
| | Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). | Q36533477 |
| | The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide | Q36655240 |
| | Activity-based protein profiling: the serine hydrolases | Q36773877 |
| | Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms | Q36798777 |
| | Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics | Q36803312 |
| | Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors | Q36819080 |
| | Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase | Q36865744 |
| | Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase | Q36865750 |
| | Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology | Q36893211 |
| | Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase | Q36914902 |
| | Biosynthetic pathways of the endocannabinoid anandamide | Q36916133 |
| | Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide | Q36961011 |
| | Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. | Q37098652 |
| | Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats | Q37146387 |
| | Targeting the endocannabinoid system: to enhance or reduce? | Q37150745 |
| | Biosynthesis, degradation and pharmacological importance of the fatty acid amides | Q37155833 |
| | Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus | Q37162125 |
| | Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception | Q37162136 |
| | An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. | Q37221702 |
| | Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates | Q37239653 |
| | Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. | Q37286808 |
| | Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors | Q37316916 |
| | Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. | Q37325801 |
| | The endogenous cannabinoid system protects against colonic inflammation | Q37370275 |
| | Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension | Q37373710 |
| | Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms | Q38757749 |
| | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse | Q39318635 |
| | Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets | Q40184192 |
| | Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1). | Q40922328 |
| | Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. | Q41214023 |
| | Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition | Q41607181 |
| | Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties | Q41683404 |
| | Clarifying the catalytic roles of conserved residues in the amidase signature family | Q41730130 |
| | Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors | Q41832173 |
| | Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models | Q42508054 |
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | fatty acid | Q61476 |
| | niacinamide | Q192423 |
| | drug discovery | Q1418791 |
| P304 | page(s) | 763-784 | |
| P577 | publication date | 2009-07-01 | |
| P1433 | published in | Expert Opinion on Drug Discovery | Q5421204 |
| P1476 | title | Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders | |
| P478 | volume | 4 | |