Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases

scientific article published on 25 June 2018

Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/MOLECULES23071526
P932PMC publication ID6099582
P698PubMed publication ID29941830

P50authorMarco BlangettiQ57056714
P2093author name stringCristina Prandi
Hinanit Koltai
Dvora Namdar
P2860cites workChemical basis of hashish activityQ93803717
The endocannabinoid system in normal and pathological brain ageingQ22242668
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effectsQ24606148
Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trialsQ24625489
Cannabinoids in health and diseaseQ24633884
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarinQ24643876
The orphan receptor GPR55 is a novel cannabinoid receptorQ24670137
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effectsQ24681369
Amorfrutins are potent antidiabetic dietary natural productsQ27678567
Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosetsQ28203208
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂Q28298445
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors.Q33845285
Pharmacological characterization of GPR55, a putative cannabinoid receptorQ33869340
Natural and synthetic endocannabinoids and their structure-activity relationshipsQ33973921
Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patientsQ33980833
Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedsideQ34019573
The endocannabinoid system as a target for the treatment of neurodegenerative diseaseQ34098196
Molecular probes for the cannabinoid receptorsQ34098959
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsyQ34146329
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcolQ34235326
Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover studyQ34358022
Pharmacological treatment of Parkinson disease: a reviewQ34416640
Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different ChemotypesQ34511965
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamidesQ34525138
Crystal Structure of the Human Cannabinoid Receptor CB1.Q34543208
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosisQ34561157
Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trialQ34638273
Medicinal chemistry endeavors around the phytocannabinoidsQ34666031
CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applicationsQ34752767
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivoQ34804266
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herbQ35001117
Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypesQ35035816
CB1 cannabinoid receptor signalling in Parkinson's diseaseQ35054346
Endocannabinoid signaling and long-term synaptic plasticity.Q35679432
Cannabinoids and glaucomaQ35748271
Pharmacology of cannabinoidsQ35782063
The good and the bad effects of (-) trans-delta-9-tetrahydrocannabinol (Delta 9-THC) on humansQ35859623
Natural cannabinoids: templates for drug discoveryQ36293580
Plant, synthetic, and endogenous cannabinoids in medicineQ36366922
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.Q36452404
Low-dose vaporized cannabis significantly improves neuropathic painQ36593518
Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesisQ36848624
The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation.Q37052244
A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic painQ37141496
The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activitiesQ37146954
Targeting the endocannabinoid system: to enhance or reduce?Q37150745
Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativaQ37390519
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in DiseaseQ37553341
Prospects for cannabinoid therapies in basal ganglia disordersQ37872326
Phytocannabinoids as novel therapeutic agents in CNS disorders.Q37933589
Endogenous cannabinoids revisited: a biochemistry perspective.Q38087791
Amorfrutins: A promising class of natural products that are beneficial to healthQ38217801
Endocannabinoids and Their Pharmacological ActionsQ38593112
GPR55 - a putative "type 3" cannabinoid receptor in inflammationQ38669741
Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor AgonistsQ38689260
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activityQ38879833
Advances in the Physiology of GPR55 in the Central Nervous SystemQ38917434
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists.Q38935374
Phytocannabinoids: a unified critical inventoryQ38976904
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptorsQ39255628
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.Q39368198
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) StudiesQ39368926
Structure-activity relationships in cannabinoidsQ39504398
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacyQ39975832
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.Q40075003
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease modelsQ42508054
Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in miceQ42731656
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseQ43504648
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.Q43641975
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot studyQ43820144
The structure of cannabitriolQ43974227
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptorQ44303656
Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorumQ44492635
6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonistQ44806888
Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonistsQ44863367
Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic painQ45004592
High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients.Q46456086
Early medical use of cannabisQ47261270
Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's diseaseQ48235219
Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPARγ receptorQ49433973
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.Q50861387
Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.Q51744729
Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties.Q52867069
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.Q53242382
Sequence heterogeneity of cannabidiolic- and tetrahydrocannabinolic acid-synthase in Cannabis sativa L. and its relationship with chemical phenotypeQ56969165
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligandsQ58855665
1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptorQ59033475
Benzimidazole CB2 agonists: Design, synthesis and SARQ60682456
[Cannabinoid system and neuroinflammation:therapeutic perspectives in multiple sclerosis]Q60696495
Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjectsQ69742476
Hashish. IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acidsQ72692479
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?Q81059625
P275copyright licenseCreative Commons AttributionQ6905323
P433issue7
P921main subjectCannabisQ79817
P577publication date2018-06-25
P1433published inMoleculesQ151332
P1476titleStructure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases
P478volume23