| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1008955012 |
| P356 | DOI | 10.1038/NCB2013 |
| P698 | PubMed publication ID | 20081843 |
| P50 | author | Giuseppina De Simone | Q28211491 |
| Emilia Pedone | Q37606098 | ||
| Evelina Miele | Q38326235 | ||
| Elisabetta Ferretti | Q38326251 | ||
| Enrico De Smaele | Q43415796 | ||
| Laura Antonucci | Q57555765 | ||
| Giuseppe Giannini | Q91254992 | ||
| Lucia Di Marcotullio | Q94543164 | ||
| P2093 | author name string | Alberto Gulino | |
| Isabella Screpanti | |||
| Alessandra Giorgi | |||
| Christian Steinkühler | |||
| Paola Gallinari | |||
| Carlo Pedone | |||
| Luigi Vitagliano | |||
| Sonia Coni | |||
| Azzura Greco | |||
| Marianna Pelloni | |||
| Laura Pietrosanti | |||
| M Eugenià Schinin | |||
| Paola Infante | |||
| P2860 | cites work | Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 | Q22009022 |
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response | Q24298620 | ||
| DBC1 is a negative regulator of SIRT1 | Q24309055 | ||
| Negative regulation of the deacetylase SIRT1 by DBC1 | Q24309090 | ||
| Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3 | Q24318805 | ||
| Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex | Q24534137 | ||
| Small molecule modulation of Smoothened activity | Q24540343 | ||
| Negative and positive regulation of gene expression by mouse histone deacetylase 1 | Q24672508 | ||
| Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain | Q27860534 | ||
| Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine | Q28138510 | ||
| Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling | Q28473090 | ||
| Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants | Q28588056 | ||
| Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors | Q28589954 | ||
| Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development | Q28594873 | ||
| Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer | Q29615649 | ||
| The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men | Q29619117 | ||
| Acetylation and deacetylation of non-histone proteins | Q29619636 | ||
| Peptide mass fingerprinting using MALDI-TOF mass spectrometry | Q30760031 | ||
| Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells | Q34816792 | ||
| Hedgehog signaling promotes medulloblastoma survival via Bc/II | Q35570435 | ||
| Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. | Q35740993 | ||
| Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases | Q36141408 | ||
| Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development | Q36509989 | ||
| REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma | Q36987393 | ||
| The coactivator CRTC1 promotes cell proliferation and transformation via AP-1 | Q37083656 | ||
| The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein | Q37187752 | ||
| Hedgehog signaling in development and cancer. | Q37350250 | ||
| Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. | Q37482716 | ||
| Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. | Q39855695 | ||
| The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A | Q40677917 | ||
| Gli1 is important for medulloblastoma formation in Ptc1+/- mice | Q42476399 | ||
| Dual degradation signals control Gli protein stability and tumor formation | Q42489576 | ||
| Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex | Q43521641 | ||
| GLI activates transcription through a herpes simplex viral protein 16-like activation domain. | Q45345890 | ||
| Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice | Q46156118 | ||
| A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. | Q47071852 | ||
| Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling | Q47073240 | ||
| Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. | Q47343275 | ||
| Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination | Q48364639 | ||
| Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma | Q48563190 | ||
| Hedgehog-Gli Signaling in Human Disease | Q60043595 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 132-142 | |
| P577 | publication date | 2010-01-17 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation | |
| P478 | volume | 12 |
| Q90633426 | A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth |
| Q46069441 | A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor |
| Q35921565 | A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity. |
| Q52646455 | A highlight on Sonic hedgehog pathway |
| Q28594488 | A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling |
| Q42643080 | A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma |
| Q91725342 | A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors |
| Q85097604 | A structure–activity relationship study of small‐molecule inhibitors of GLI1‐mediated transcription |
| Q48215997 | A synthetic combinatorial approach to disabling deviant Hedgehog signaling |
| Q82696715 | Acetylation controls Notch3 stability and function in T-cell leukemia |
| Q36547802 | Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. |
| Q37607838 | Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling |
| Q24336527 | Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase |
| Q35579337 | Alberto Gulino MD, PhD (1952-2014) |
| Q34185751 | Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. |
| Q37583341 | An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. |
| Q35950995 | Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway |
| Q60047613 | Application of Small Epigenetic Modulators in Pediatric Medulloblastoma |
| Q37232765 | Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity |
| Q34046454 | C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. |
| Q37641536 | CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc |
| Q42681991 | Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis |
| Q35108046 | Clinical implications of hedgehog signaling pathway inhibitors |
| Q46767544 | Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment |
| Q37677356 | Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals |
| Q27027214 | Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy |
| Q58696815 | Contribution of KCTD12 to esophageal squamous cell carcinoma |
| Q100311434 | Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics |
| Q38059538 | Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection |
| Q26865136 | Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy |
| Q34361233 | Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells |
| Q99365591 | Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemia |
| Q38011541 | Crosstalk between TGF-β and hedgehog signaling in cancer. |
| Q35631852 | Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins |
| Q35596110 | Cullin3-BTB interface: a novel target for stapled peptides |
| Q33875921 | Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo |
| Q28833786 | DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance |
| Q38056842 | Deregulated Chromatin Remodeling in the Pathobiology of Brain Tumors |
| Q58466764 | Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition |
| Q41716968 | Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth |
| Q35149722 | Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development |
| Q89106431 | Embryology |
| Q38058972 | Epigenetic alterations involved in cancer stem cell reprogramming |
| Q47900778 | Epigenetic regulation in medulloblastoma |
| Q37618640 | Epigenetics in cancer stem cells |
| Q27320001 | Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes |
| Q26824651 | Expanding Proteostasis by Membrane Trafficking Networks |
| Q39574696 | Expression, purification, and secondary structure characterization of recombinant KCTD1 |
| Q39252748 | From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases |
| Q47413250 | Functional analysis of Cullin 3 E3 ligases in tumorigenesis. |
| Q92989376 | GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling |
| Q47148860 | Generation and characterization of Kctd15 mutations in zebrafish |
| Q28312135 | Genes regulated by potassium channel tetramerization domain containing 15 (Kctd15) in the developing neural crest |
| Q64245029 | Gli Proteins: Regulation in Development and Cancer |
| Q34981146 | Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. |
| Q34770115 | Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy |
| Q47335978 | HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation. |
| Q36002803 | Hedgehog Secretion and Signal Transduction in Vertebrates |
| Q99591085 | Hedgehog Signaling and Truncated GLI1 in Cancer |
| Q42474956 | Hedgehog controls neural stem cells through p53-independent regulation of Nanog |
| Q36463282 | Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein |
| Q38359705 | Hedgehog signaling in cancer stem cells: a focus on hematological cancers. |
| Q37852292 | Hedgehog signaling in skin cancers |
| Q27021460 | Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma |
| Q35005479 | Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells |
| Q57905193 | Hedgehog signalling pathway inhibitors as cancer suppressing agents |
| Q30499964 | Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer |
| Q33864635 | Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. |
| Q36002979 | Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 |
| Q93080888 | Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors |
| Q36962569 | In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. |
| Q28312142 | Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2 |
| Q38477392 | Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage |
| Q33914111 | KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling |
| Q42728434 | KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma. |
| Q36548661 | KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway |
| Q91105619 | KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2 |
| Q92289370 | KCTD15 is overexpressed in human childhood B-cell acute lymphoid leukemia |
| Q47100880 | KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence |
| Q40577385 | KCTD5 is endowed with large, functionally relevant, interdomain motions |
| Q92738485 | KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
| Q64066854 | Krüppel-like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway |
| Q90021369 | LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription |
| Q61714951 | Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling |
| Q27021965 | Lysine deacetylase (KDAC) regulatory pathways: an alternative approach to selective modulation |
| Q36541232 | MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification |
| Q41335500 | Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway. |
| Q37982341 | Matching mice to malignancy: molecular subgroups and models of medulloblastoma |
| Q37995022 | Medulloblastoma stem cells: where development and cancer cross pathways. |
| Q91826570 | Medulloblastomics revisited: biological and clinical insights from thousands of patients |
| Q64226720 | Meeting the Challenge of Targeting Cancer Stem Cells |
| Q39794708 | Menin directly represses Gli1 expression independent of canonical Hedgehog signaling |
| Q26860745 | Metabolic reprogramming by class I and II histone deacetylases |
| Q93357335 | Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation |
| Q92035269 | Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants |
| Q34315290 | Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis |
| Q34292500 | NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations |
| Q42702677 | New Aspects of Vascular Calcification: Histone Deacetylases and Beyond. |
| Q64912138 | Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy. |
| Q26783611 | Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions |
| Q64992804 | Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened. |
| Q47144270 | Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma |
| Q24298764 | Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal |
| Q46075208 | Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation |
| Q91594913 | Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development |
| Q35832313 | Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy |
| Q39098638 | PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress |
| Q39289781 | Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. |
| Q64244529 | Polyamine Metabolism as a Therapeutic Target inHedgehog-Driven Basal Cell Carcinomaand Medulloblastoma |
| Q90318276 | Postnatal Ethanol Exposure Activates HDAC-Mediated Histone Deacetylation, Impairs Synaptic Plasticity Gene Expression and Behavior in Mice |
| Q38116920 | Primary cilia and graded Sonic Hedgehog signaling |
| Q34196045 | Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons. |
| Q37155839 | Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor. |
| Q90426558 | Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma |
| Q37833362 | Protected from the inside: Endogenous histone deacetylase inhibitors and the road to cancer |
| Q41738818 | Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment. |
| Q36041364 | Regulation of Hedgehog signaling by ubiquitination |
| Q34518987 | Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling |
| Q55384318 | Role and inhibition of GLI1 protein in cancer. |
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| Q35054111 | SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme |
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| Q37690128 | Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. |
| Q48640710 | Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects |
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