Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

scientific article published on 01 June 2018

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CCELL.2018.05.003
P932PMC publication ID6005359
P698PubMed publication ID29894692

P50authorMichael KarinQ1458081
Elisabeth GlitznerQ41133405
Maria SibiliaQ41133496
Hayato NakagawaQ80174875
Ling YangQ87742475
P2093author name stringJan Tuckermann
Ekihiro Seki
Jessica Zucman-Rossi
Mark A Valasek
Laura Antonucci
Sooyeon Lee
Stefano Caruso
Debanjan Dhar
Ju Youn Kim
Shabnam Shalapour
Kerstin Minnich
P2860cites workDNA Damage, Aging, and CancerQ22121931
Alcohol metabolismQ24621827
Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinomaQ27487515
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repairQ37357884
Stem cells and cancer of the stomach and intestineQ37769649
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?Q37851351
Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequencesQ38116295
Tumor-Suppressor Functions of the TP53 PathwayQ38824332
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformationQ39003817
Histone H2AX Phosphorylation: A Marker for DNA DamageQ39286636
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylationQ39750898
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylationQ40767550
Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal AdenocarcinomaQ41856856
Single-cell spatial reconstruction reveals global division of labour in the mammalian liverQ42320342
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1Q42766950
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunityQ46066476
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesisQ46576855
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivoQ46868554
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in miceQ51369659
Expression pattern of Wnt signaling components in the adult intestineQ52042359
CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsetsQ52173790
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.Q53299056
Chemical composition and tissue distribution of the human CDw44 glycoproteinQ54352509
A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver ResectionQ57756525
Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regenerationQ70988072
Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cellsQ73407060
Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survivalQ73444664
Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinomaQ80522943
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signalingQ28117922
CD44: from adhesion molecules to signalling regulatorsQ28201701
Hepatocellular carcinoma: epidemiology and molecular carcinogenesisQ28306363
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathwayQ28505373
Live or let die: the cell's response to p53Q29547663
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionQ29614596
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionQ29615766
Suppression of induced pluripotent stem cell generation by the p53-p21 pathwayQ29619160
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter bindingQ30308636
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exitQ30577210
Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signalingQ33588191
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumorsQ33613105
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesisQ33640296
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activationQ33737707
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinomaQ33863710
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesisQ33944283
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusQ33944754
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.Q34164259
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formationQ34282375
p53 Research: the past thirty years and the next thirty years.Q34313764
The p53 and Mdm2 families in cancer.Q34493139
Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cellsQ34608700
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progressionQ34627193
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expressionQ35568362
Control of apoptosis by p53.Q35603381
CD44 is required for two consecutive steps in HGF/c-Met signaling.Q35805198
Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytesQ35829671
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to CancerQ35985007
The EGF receptor is required for efficient liver regenerationQ36089334
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 ActivityQ36387594
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factorQ36653753
Cancer stem cells in the development of liver cancerQ36793453
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progressionQ37152303
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesisQ37255168
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.Q37264062
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectliver cancerQ623031
P53Q7117920
DNA damage responseQ30231004
P304page(s)1061-1077.e6
P577publication date2018-06-01
P1433published inCancer CellQ280018
P1476titleLiver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
P478volume33

Reverse relations

cites work (P2860)
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Q99630796Dietary Additives and Supplements Revisited: The Fewer, the Safer for Liver and Gut Health
Q91793987Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform
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Q90471308IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner
Q98612825Long Non-Coding RNA LOXL1-AS1 Enhances Colorectal Cancer Proliferation, Migration and Invasion Through miR-708-5p/CD44-EGFR Axis
Q89995774Long non-coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3
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Q89612188Small Nucleolar RNA Host Gene 1 (SNHG1) and Chromosome 2 Open Reading Frame 48 (C2orf48) as Potential Prognostic Signatures for Liver Cancer by Constructing Regulatory Networks
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