Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

scientific article published on 29 November 2012

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CCR.2012.10.025
P932PMC publication ID3568632
P698PubMed publication ID23201164
P5875ResearchGate publication ID233827472

P50authorGuido von FiguraQ63133710
P2093author name stringHaruhiko Akiyama
Christopher V E Wright
Kristin Jensen
Maike Sander
John P Morris
Matthias Hebrok
Claire L Dubois
Janel L Kopp
Fong Cheng Pan
Erin Mayes
Fen-Fen Liu
P2860cites workIdentification of a cell of origin for human prostate cancerQ24594400
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SOX9 is required for maintenance of the pancreatic progenitor cell poolQ28510325
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formationQ28510770
EGF receptor is required for KRAS-induced pancreatic tumorigenesisQ28584901
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreasQ28584996
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
Cells of origin in cancerQ29619557
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreasQ33591500
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasiaQ33754775
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceQ61776577
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesisQ73614651
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse modelQ33818230
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic KrasQ34082522
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancerQ34241383
Genetics and biology of pancreatic ductal adenocarcinoma.Q34567515
Context-dependent transformation of adult pancreatic cells by oncogenic K-RasQ34620985
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.Q35097448
Hedgehog/Ras interactions regulate early stages of pancreatic cancerQ35127709
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasiaQ35663506
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.Q35921887
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasiaQ35928158
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiationQ36058628
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasiaQ36478584
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinomaQ36696146
Molecular genetics of pancreatic intraepithelial neoplasiaQ36829524
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasiaQ36980230
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult miceQ36999854
Stabilization of beta-catenin induces pancreas tumor formationQ37034716
Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasiaQ37249748
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasiaQ37501557
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine networkQ38626764
Pancreatic Intraepithelial NeoplasiaQ38720267
Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.Q39337159
Notch1 signaling regulates chondrogenic lineage determination through Sox9 activationQ39484183
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinomaQ39885220
SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathwayQ40149526
Hedgehog signaling is required for effective regeneration of exocrine pancreasQ41761890
Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regenerationQ41791253
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasiaQ41816001
Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signalingQ41858645
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.Q41979160
Notch signaling controls liver development by regulating biliary differentiationQ42080795
Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitorsQ42473171
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.Q42876632
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birthQ43199149
Recapitulation of elements of embryonic development in adult mouse pancreatic regenerationQ46376132
Pten constrains centroacinar cell expansion and malignant transformation in the pancreasQ46708964
The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascadeQ47867912
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.Q51056982
Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.Q52172849
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.Q53329413
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.Q53379869
P433issue6
P921main subjectadenocarcinomaQ356033
P304page(s)737-750
P577publication date2012-11-29
P1433published inCancer CellQ280018
P1476titleIdentification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
P478volume22

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