Pancreatic Cancer Genetics

scientific article

Pancreatic Cancer Genetics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.7150/IJBS.15001
P932PMC publication ID4753160
P698PubMed publication ID26929738

P50authorLaufey T. AmundadottirQ30093106
P2860cites workFunctional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locusQ21134596
Genome-wide association study of pancreatic cancer in Japanese populationQ21136247
Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear familyQ21144736
Finding the missing heritability of complex diseasesQ22122198
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33Q23924183
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequenceQ24311830
C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoAQ24313007
Structural basis for recruitment of BRCA2 by PALB2Q24315745
A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growthQ24318407
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerQ24320153
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studiesQ24531993
Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the youngQ57916579
Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion ofp16 (p16-Leiden)Q57948729
Renal tubular cells cultured from genetically modified animalsQ73177058
Exonic duplication of the hepatocyte nuclear factor-1beta gene (transcription factor 2, hepatic) as a cause of maturity onset diabetes of the young type 5Q80171612
PALB2 mutations in European familial pancreatic cancer familiesQ84094246
ABO blood group and risk of colorectal cancerQ34949621
Chromosome 8q24-Associated Cancers and MYC.Q34972340
Sox9: a master regulator of the pancreatic programQ34972366
Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancerQ35056055
Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locusQ35085806
Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.Q35118758
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.Q35193215
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE studyQ35630278
The functional spectrum of low-frequency coding variationQ35840674
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancerQ35904497
The 8q24 gene desert: an oasis of non-coding transcriptional activity.Q35919877
Systemic cancer and the FAMMM syndromeQ35982685
Genetic and clinical characteristics of maturity-onset diabetes of the youngQ36162489
The CDKN2A (p16) gene and human cancer.Q36437816
The ATM-dependent DNA damage signaling pathwayQ36547714
A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survivalQ36600132
Genetic susceptibility to pancreatic cancerQ36603692
TP63 gene in stress response and carcinogenesis: a broader role than expectedQ36689506
Human pancreatic digestive enzymesQ36700204
Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulationQ36843160
Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1Q24533305
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
A relationship between cancer of stomach and the ABO blood groupsQ24565002
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33Q24597370
ABO blood group and incidence of epithelial ovarian cancerQ24599521
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisQ24609915
Mammalian Krüppel-Like Factors in Health and DiseasesQ24612560
New common variants affecting susceptibility to basal cell carcinomaQ24615109
A map of human genome variation from population-scale sequencingQ24617794
Control of pancreas and liver gene expression by HNF transcription factorsQ24618003
Biological, clinical and population relevance of 95 loci for blood lipidsQ24622541
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancerQ24626464
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypesQ24635080
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association studyQ24644661
Lung cancer susceptibility locus at 5p15.33Q24649980
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaQ24657797
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility geneQ24658271
Implications of telomere-independent activities of telomerase reverse transcriptase in human cancerQ26825812
Global cancer statistics, 2012Q27860501
Cancer statistics, 2015Q27860576
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Human histo-blood group A2 transferase coded by A2 allele, one of the A subtypes, is characterized by a single base deletion in the coding sequence, which results in an additional domain at the carboxyl terminalQ28115513
Creation of human tumour cells with defined genetic elementsQ28141602
A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosisQ28143357
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitisQ28145585
Clinical and genetic characteristics of hereditary pancreatitis in EuropeQ28250117
Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epitheliumQ28279620
p130Cas: a key signalling node in health and diseaseQ28282363
Integrin signalling adaptors: not only figurants in the cancer storyQ28299126
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promotersQ28299313
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study GroupQ28307042
Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer riskQ28385765
TERT gene harbors multiple variants associated with pancreatic cancer susceptibilityQ28386653
Cancer risks in BRCA2 mutation carriersQ34504452
Very high risk of cancer in familial Peutz-Jeghers syndromeQ34512286
Cancer Incidence in BRCA1 mutation carriersQ34527264
Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC).Q34583807
Pancreatic cancer and the FAMMM syndromeQ34584733
Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A.Q34586212
Extra-intestinal manifestations of familial adenomatous polyposisQ34593970
Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literatureQ34603196
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detectionQ34620078
Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillanceQ34646423
European cancer mortality predictions for the year 2014.Q34661464
ABO blood groups and risk of cancer: a systematic review and meta-analysisQ34662761
Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counselingQ34694716
Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.Q34699663
High trans-ethnic replicability of GWAS results implies common causal variants.Q34778535
Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarianQ34945185
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in AsiaQ28397565
The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 elementQ28588078
Discovery and refinement of loci associated with lipid levelsQ28661470
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populationsQ28943254
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303Q28943270
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemiaQ28943339
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Q28943480
Genome-wide association study of survival in patients with pancreatic adenocarcinomaQ28943489
Genome-wide association study identifies three new melanoma susceptibility lociQ29416994
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityQ29417007
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancerQ29417028
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association studyQ29417074
Genome-wide association study identifies five susceptibility loci for gliomaQ29614921
Sequence variants at the TERT-CLPTM1L locus associate with many cancer typesQ29614935
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetesQ30416868
Structure and function of ETAA16: a novel cell surface antigen in Ewing's tumoursQ33218440
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.Q33480141
CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cellsQ33648848
Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancerQ33783766
Risk of pancreatic cancer in families with Lynch syndromeQ33880380
Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2Q34038331
p63 and p73, the ancestors of p53.Q34080237
Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).Q34080597
Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortiumQ34094983
Nonsense and missense mutations in the human hepatocyte nuclear factor-1 beta gene (TCF2) and their relation to type 2 diabetes in JapaneseQ34142684
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancerQ34241383
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancerQ34314018
LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesisQ34319158
The epidemiology of pancreatitis and pancreatic cancerQ34341477
BRCA1 and BRCA2: 1994 and beyondQ34345297
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposisQ34378109
Dax1 Up-Regulates Oct4 Expression in Mouse Embryonic Stem Cells via LRH-1 and SRAQ34392546
Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortiumQ34422433
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expressionQ36856343
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancerQ36897003
ATM mutations in patients with hereditary pancreatic cancerQ36913473
Genetic risk factors for pancreatic disordersQ36933359
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerQ36956156
Transcription factors in pancreatic development. Animal modelsQ36965587
CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?Q37001375
Risk of pancreatic cancer in breast cancer families from the breast cancer family registryQ37085786
BRCA1 and BRCA2: different roles in a common pathway of genome protectionQ37149848
Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in probandQ37222641
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseasesQ37486142
Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancerQ37557629
High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendationsQ37669153
History, genetics, and strategies for cancer prevention in Lynch syndromeQ37716875
Transcriptional control of acinar development and homeostasisQ37809241
Role of p63 in cancer development.Q37868336
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesisQ38002202
Familial pancreatic cancer--current knowledgeQ38016055
Targeting LKB1 signaling in cancer.Q38071485
ABO blood group: old dogma, new perspectivesQ38104553
Novel mutations and a mutational hotspot in the MODY3 geneQ38345643
Familial Adenomatous Polyposis (FAP)-A Case Study and Review of LiteratureQ38466964
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiationQ39156056
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human diseaseQ39978997
Common variants in HNF-1 alpha and risk of type 2 diabetesQ40280144
IPF1, a homeodomain-containing transactivator of the insulin geneQ40874284
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
Familial and second primary pancreatic cancers: a nationwide epidemiologic study from SwedenQ42690527
Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortiumQ43538243
A population-based description of familial clustering of pancreatic cancerQ44928964
Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogenQ46911281
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)Q48056898
Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutationsQ48746431
Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.Q51061806
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.Q53307573
Increased Risk of Cancer Other Than Melanoma in CDKN2A Founder Mutation (p16-Leiden)-Positive Melanoma FamiliesQ56436681
High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMELQ56437244
Heterogeneity of risk for melanoma and pancreatic and digestive malignanciesQ57250703
Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian PopulationsQ57610440
The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent CellsQ57783827
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
pancreatic neoplasmQ7130412
P304page(s)314-25
P577publication date2016-01-28
P1433published inInternational Journal of Biological SciencesQ6051326
P1476titlePancreatic Cancer Genetics
P478volume12

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