Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

scientific article

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1084511345
P356DOI10.1038/CR.2017.51
P8608Fatcat IDrelease_3b2kksxlunazjpkjwselzu2crm
P932PMC publication ID5518983
P698PubMed publication ID28374746

P50authorMichael T LotzeQ89121415
Herbert J. Zeh, IIIQ92244196
David L BartlettQ97424233
Timothy BilliarQ30223707
Haichao WangQ37375045
P2093author name stringDaolin Tang
Rui Kang
Shan Zhu
Jinbao Liu
Wen Hou
Yangchun Xie
Qiuhong Zhang
Dexing Zeng
Qingping Jiang
P2860cites workEndogenous HMGB1 regulates autophagyQ24298865
Chromosomal instability and cancer: a complex relationship with therapeutic potentialQ24608609
Pancreatic ductal cells in development, regeneration, and neoplasiaQ27006729
Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineageQ27312357
Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injuryQ27334890
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNAQ27680115
HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tailQ27682786
Cancer statistics, 2015Q27860576
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenalQ28242907
HMGB1 and RAGE in inflammation and cancerQ28274621
Masquerader: high mobility group box-1 and cancerQ28302492
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistanceQ28504893
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma.Q53371627
Pancreatic AdenocarcinomaQ55880513
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastasesQ59084980
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteinsQ67601392
Long-term stability of circulating nucleosomes in serumQ84510027
SOX9 is required for maintenance of the pancreatic progenitor cell poolQ28510325
High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damageQ28513347
THE COMPLEX STRUCTURE AND DYNAMIC EVOLUTION OF HUMAN SUBTELOMERESQ29393384
DAMPs, PAMPs and alarmins: all we need to know about dangerQ29547535
GammaH2AX and cancerQ29614974
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGEQ29620722
A combination of molecular markers and clinical features improve the classification of pancreatic cystsQ30724746
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progressionQ33787458
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
Pancreatic cancer, inflammation, and microbiomeQ33956107
Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation TherapyQ34118056
Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesionsQ34244725
New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signalQ34334123
The epidemiology of pancreatitis and pancreatic cancerQ34341477
Organoid models of human and mouse ductal pancreatic cancerQ34456438
RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancerQ34541682
HMGB1 in health and diseaseQ34622835
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Q34786695
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreasQ34792019
Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis miceQ34874768
8-Hydroxyguanine: From its discovery in 1983 to the present statusQ35068187
Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional outputQ35073809
Drugging the undruggable RAS: Mission possible?Q35163434
Nuclear DAMP complex-mediated RAGE-dependent macrophage cell deathQ35164703
Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injuryQ35175597
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.Q35183879
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in miceQ35541859
Release and activity of histone in diseasesQ35679542
High-mobility group box 1 is essential for mitochondrial quality controlQ35800479
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasiaQ35935777
HMGB1 is a therapeutic target for sterile inflammation and infectionQ35953553
Sox9 coordinates a transcriptional network in pancreatic progenitor cellsQ35973342
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.Q36193536
TLR9 ligation in pancreatic stellate cells promotes tumorigenesisQ36286020
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinomaQ36384268
RAGE signaling sustains inflammation and promotes tumor developmentQ36502858
Epithelial metaplasia and the development of cancer.Q36873310
The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis.Q36905963
HMGB1 in cancer: good, bad, or both?Q37067481
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergeticsQ37227378
Molecular classification of neoplasms of the pancreasQ37442092
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasiaQ37501557
Molecular and cellular regulation of pancreatic acinar cell functionQ37538446
SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasmsQ37621990
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in miceQ37662678
Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?Q37897800
Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology.Q37923241
What we have learned about pancreatic cancer from mouse models.Q37992454
Predictive in vivo animal models and translation to clinical trialsQ38001718
Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cellsQ38022404
Relevance of animal models of pancreatic cancer and pancreatitis to human diseaseQ38102104
Dragging ras back in the ringQ38197825
Pancreatic cancer: from state-of-the-art treatments to promising novel therapiesQ38396634
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic CarcinogenesisQ38786245
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.Q38916311
HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction.Q39356760
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Q39540918
High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapyQ40099916
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in miceQ40679145
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune responseQ40899986
Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cellsQ41697061
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activitiesQ42828870
Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasiaQ42937848
Nucleosomes in serum as a marker for cell deathQ43719377
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanomaQ46279328
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P921main subjectpancreatic cancerQ212961
P304page(s)916-932
P577publication date2017-04-04
P1433published inCell ResearchQ1524018
P1476titleIntracellular HMGB1 as a novel tumor suppressor of pancreatic cancer
P478volume27

Reverse relations

cites work (P2860)
Q48341352Anticancer and Immunogenic Properties of Cardiac Glycosides
Q64112676Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma
Q64237150Cancer-cell-secreted CXCL11 promoted CD8 T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
Q92540151Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma
Q104459068Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
Q47391467HMGB1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis.
Q57109153HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium
Q55343196HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.
Q92015253Identification of a key candidate gene‑phenotype network mediated by glycyrrhizic acid using pharmacogenomic analysis
Q38695950Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Q90029047Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein
Q47285488JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice
Q92404751Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1
Q89907564Knockdown of HMGB1 Suppresses Hypoxia-Induced Mitochondrial Biogenesis in Pancreatic Cancer Cells
Q87853391MicroRNA-935 inhibits proliferation and invasion of osteosarcoma cells by directly targeting High mobility group box 1
Q57461792Novel dihydroartemisinin derivative DHA-37 induces autophagic cell death through upregulation of HMGB1 in A549 cells
Q92507403Prolactin Promotes Fibrosis and Pancreatic Cancer Progression
Q52584324Proteomic biomarkers in body fluids associated with pancreatic cancer.
Q89484239RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer-a Review
Q55191109RAGE-specific single chain Fv for PET imaging of pancreatic cancer.
Q52609417Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis.
Q52720171Regulation of Tumor Progression by Programmed Necrosis.
Q101121160Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis
Q61631793The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis
Q64261339The dark side of radiotherapy-induced cell death in cancer
Q92669310Tumor suppressor function of miR-129-5p in lung cancer
Q99564729Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer

Search more.