Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

scientific article published on 9 January 2012

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI59227
P932PMC publication ID3266788
P698PubMed publication ID22232209

P2093author name stringCraig J Galbán
Marina Pasca di Magliano
Meredith A Collins
Stefanie Galbán
Filip Bednar
Yaqing Zhang
N Volkan Adsay
Jean-Christophe Brisset
Sabita Rakshit
Karen S Flannagan
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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
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Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.Q33304986
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse modelQ33818230
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesionsQ34244725
Genetics and biology of pancreatic ductal adenocarcinoma.Q34567515
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouseQ34596182
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liverQ34607172
Context-dependent transformation of adult pancreatic cells by oncogenic K-RasQ34620985
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
Maximizing mouse cancer modelsQ34661270
Long-term survival after multidisciplinary management of resected pancreatic adenocarcinomaQ34732306
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Q34786695
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreasQ34792019
Modelling Myc inhibition as a cancer therapyQ34811008
Hedgehog/Ras interactions regulate early stages of pancreatic cancerQ35127709
Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alphaQ35606708
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancerQ36096239
Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprintingQ36287900
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.Q36362278
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasiaQ36478584
The use of targeted mouse models for preclinical testing of novel cancer therapeutics.Q36603681
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)639-653
P577publication date2012-01-09
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleOncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
P478volume122

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