Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions

scientific article published on 2 August 2016

Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.11013
P932PMC publication ID5342700
P698PubMed publication ID27494892

P50authorAndreia V PinhoQ56482259
Nils ElingQ57496148
Simone CamargoQ63981424
Ilse RoomanQ83181310
Andrew BiankinQ38802580
P2093author name stringAmanda Mawson
Jianmin Wu
Anthony Gill
Marc Giry-Laterriere
Mehreen Arshi
Evelyne Kuster
Max Warmerdam
Triyana Lie
P2860cites workPancreatic cancer genomes reveal aberrations in axon guidance pathway genesQ24595981
Diverse roles of SIRT1 in cancer biology and lipid metabolismQ26997827
Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of HyperglycemiaQ27305957
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinomaQ27852569
Sirtuins in mammals: insights into their biological functionQ29615248
Epigenetic protein families: a new frontier for drug discoveryQ29616621
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
Metabolic reprogramming: a cancer hallmark even warburg did not anticipateQ29617612
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceQ29619786
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse modelQ31120854
SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.Q39276801
PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.Q39474407
SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cellsQ39523760
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in miceQ40679145
c-MYC and SIRT1 locked in a vicious cycleQ42548615
Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancerQ47987813
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.Q53242589
Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer.Q53258776
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in miceQ33604863
How does SIRT1 affect metabolism, senescence and cancer?Q33802917
The complex landscape of pancreatic cancer metabolismQ33827703
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cellsQ33880100
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancerQ33890004
Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signalingQ34104012
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Q34195003
An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's diseaseQ35135962
DBC1 functions as a tumor suppressor by regulating p53 stabilityQ35152261
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial functionQ35223050
SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.Q35749349
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinibQ35774432
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 FunctionQ35958099
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitorsQ35961180
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.Q36078757
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolismQ36319414
Janus-faced role of SIRT1 in tumorigenesisQ36403645
Glucose metabolism as a target of histone deacetylase inhibitors.Q37125470
SIRT1: Regulator of p53 DeacetylationQ37150526
The emerging and diverse roles of sirtuins in cancer: a clinical perspectiveQ37231067
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureQ37412140
SIRT1 and other sirtuins in metabolismQ37619655
The diversity of histone versus nonhistone sirtuin substrates.Q38135829
KRAS: feeding pancreatic cancer proliferationQ38175666
SIRT1 metabolic actions: Integrating recent advances from mouse modelsQ38190964
SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxiaQ38298978
Pancreatic cancer: from state-of-the-art treatments to promising novel therapiesQ38396634
Emerging Drug Target In Pancreatic Cancer: Placing Sirtuin 1 on the Canvas.Q38568551
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulationQ38884503
Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRADQ38966981
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
P4510describes a project that usesImageJQ1659584
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)74768-74778
P577publication date2016-08-02
P1433published inOncotargetQ1573155
P1476titleSirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
P478volume7

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cites work (P2860)
Q60919715Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited
Q92445902Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women
Q90207146KRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer
Q92731070Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1
Q45419184The Glycolytic Switch in Tumors: How Many Players Are Involved?

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