Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas

scientific article published on 23 July 2018

Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1242/DMM.033373
P932PMC publication ID6078397
P698PubMed publication ID30037967

P50authorJoseph BurclaffQ59684701
Jason C MillsQ88427777
P2860cites workTransplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' EggsQ24519327
An immunocytochemical and morphometric study of the rat pancreatic isletsQ24531579
The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the MistQ24630749
Mature chief cells are cryptic progenitors for metaplasia in the stomachQ24631089
The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identityQ24653476
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.Q24658509
Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tractQ26801731
Dedifferentiation and reprogramming: origins of cancer stem cellsQ26826876
YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 SignalingQ40989829
Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric GlandsQ41458995
Tritiated thymidine autoradiographic study on cellular migration in the gastric gland of the golden hamsterQ41517837
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and diseaseQ41737306
Hedgehog signaling is required for effective regeneration of exocrine pancreasQ41761890
Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer.Q41861115
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cellsQ42026806
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activationQ42091306
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Q42269245
The Gastric Epithelium: Slow Starter in the Stem Cell/Lineage Specification Stakes?Q42389501
Reversible drug-induced oxyntic atrophy in ratsQ42488660
Early requirement of Rac1 in a mouse model of pancreatic cancer.Q42490195
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescenceQ42573716
Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cellsQ42729081
K-ras mutations in pancreatic ductal proliferative lesionsQ42753837
c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasisQ42775601
TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreasQ43826975
Intestinal stem cell replacement follows a pattern of neutral driftQ44951523
Recapitulation of elements of embryonic development in adult mouse pancreatic regenerationQ46376132
Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression.Q47111525
Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomachQ47302381
Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cellQ47566401
Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequenceQ47786705
Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in StomachQ48017785
A chief source of cancer and repair in stomachs.Q48192570
Cell plasticity in epithelial homeostasis and tumorigenesis.Q48296335
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.Q48328395
Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief CellsQ49722529
Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancerQ49788912
Mature gastric chief cells are not required for the development of metaplasia.Q49967633
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.Q50219168
Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.Q50422422
Cellular reprogramming in skin cancerQ27027468
A genetic model for colorectal tumorigenesisQ27860582
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Targeting RAS signalling pathways in cancer therapyQ28201363
Quantification of crypt and stem cell evolution in the normal and neoplastic human colonQ28246034
In vivo reprogramming of adult pancreatic exocrine cells to beta-cellsQ28292190
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumQ28300176
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.Q28307731
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genesQ28307762
EGF receptor is required for KRAS-induced pancreatic tumorigenesisQ28584901
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasiaQ28589628
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cellsQ29619410
Cells of origin in cancerQ29619557
Heart regeneration in zebrafishQ29619776
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected miceQ33205595
Pathobiology of Helicobacter pylori-Induced Gastric CancerQ33361550
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in miceQ33680759
Metaplasia in the Stomach Arises From Gastric Chief CellsQ33714766
Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric CorpusQ33714773
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signalingQ33929630
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpolesQ33970945
Dedifferentiation, transdifferentiation and reprogramming: three routes to regenerationQ34025442
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic KrasQ34082522
The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.Q34087033
Plasticity and reprogramming of differentiated cells in amphibian regenerationQ34142489
Gastric epithelial stem cellsQ34154012
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of miceQ34222321
Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progressionQ34330645
The multistep nature of cancerQ34366937
TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.Q34380608
Cytodifferentiation of the postnatal mouse stomach in normal and Huntingtin-interacting protein 1-related-deficient miceQ34425956
Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: possible role of TGFalpha/EGFR.Q50450228
A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach.Q50455880
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.Q50517982
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas.Q50539043
Acinar Ductal Metaplasia: Yap Fills a Gap.Q50859291
Lgr5 joins the club of gastric stem cell markers in the corpus.Q50917892
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.Q51056982
Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.Q51061806
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.Q51894736
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic miceQ53379866
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis.Q54394742
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceQ61776577
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breastQ67660860
Development of adenocarcinomas in the stomachQ68954575
Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cellsQ72848879
Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distributionQ73258134
The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevisQ78862450
Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient miceQ81264382
Re-evaluation of histogenesis of gastric carcinomas: a comparative histopathological study between Helicobacter pylori-negative and H. pylori-positive casesQ81795383
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinomaQ82193149
Heart of newt: a recipe for regenerationQ84434706
Oncofetal signaling as a target for cancer therapyQ87543989
Experimental models of pancreatitisQ88110599
Paligenosis: prepare to regenerate!Q88137469
A single transcription factor is sufficient to induce and maintain secretory cell architectureQ37661675
Refining the role for adult stem cells as cancer cells of originQ38252977
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.Q38710117
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic CarcinogenesisQ38786245
Cellular plasticity: 1712 to the present day.Q38916687
Acinar cell plasticity and development of pancreatic ductal adenocarcinomaQ38922230
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiationQ39156056
NF-κB Signaling in Gastric Cancer.Q39204794
Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.Q39337159
A human model of gastric carcinogenesis.Q39644851
Retrodifferentiation and the Fetal Patterns of Gene Expression in CancerQ39805011
The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiationQ39958892
Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells.Q39979747
Distinct prognostic values of YAP1 in gastric cancerQ40256327
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in miceQ40679145
Multipotential stem cells in adult mouse gastric epitheliumQ40710512
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous LesionsQ34517052
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110αQ34590266
PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in miceQ34616196
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesionsQ34943207
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasiaQ35376826
Risk of pancreatic adenocarcinoma in chronic pancreatitisQ35595218
The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.Q35732360
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasiaQ35928158
Identification and analysis of precursors to invasive pancreatic cancer.Q35948700
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinomaQ35954277
Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.Q35994058
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.Q36386294
SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine.Q36452176
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasiaQ36478584
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restorationQ36570146
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in miceQ36677747
Acute pancreatitis: animal models and recent advances in basic researchQ36696668
Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage TransitionsQ36730863
The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturationQ36733456
Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cellsQ36765691
Dynamics of epithelial cells in the corpus of the mouse stomach. V. Behavior of entero-endocrine and caveolated cells: general conclusions on cell kinetics in the oxyntic epitheliumQ36765694
Hippo signaling regulates differentiation and maintenance in the exocrine pancreasQ36881032
The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferationQ36890737
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasiaQ36980230
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult miceQ36999854
Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomachQ37003243
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.Q37071752
Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis.Q37259840
MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.Q37413667
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasiaQ37501557
Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss.Q37572782
Murine Models of Gastric Corpus Preneoplasia.Q37594950
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P921main subjectstomachQ1029907
cell differentiationQ210861
wound healingQ1509074
carcinogenesisQ1637543
P577publication date2018-07-23
P1433published inDisease Models & MechanismsQ1524006
P1476titlePlasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas
P478volume11

Reverse relations

cites work (P2860)
Q90237358Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia
Q58778696Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine
Q90564951Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia
Q98291542Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection
Q57167592The big picture: exploring the metabolic cross-talk in cancer

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