| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1084129691 |
| P356 | DOI | 10.1038/NRGASTRO.2017.12 |
| P8608 | Fatcat ID | release_vjbbeabafnfljpaaj3bty6kz2y |
| P932 | PMC publication ID | 6036907 |
| P698 | PubMed publication ID | 28270694 |
| P2093 | author name string | Peter Storz | |
| P2860 | cites work | The epithelial-mesenchymal transition generates cells with properties of stem cells | Q24650786 |
| The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity | Q24653476 | ||
| Control of cell identity in pancreas development and regeneration | Q27021239 | ||
| Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage | Q27312357 | ||
| Sox9b is a key regulator of pancreaticobiliary ductal system development | Q27333515 | ||
| Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis | Q27334054 | ||
| A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas | Q28082890 | ||
| EGF receptor is required for KRAS-induced pancreatic tumorigenesis | Q28584901 | ||
| The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas | Q28589516 | ||
| Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia | Q28589628 | ||
| Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development | Q28592848 | ||
| EMT and dissemination precede pancreatic tumor formation | Q29615854 | ||
| Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors | Q29619012 | ||
| Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas | Q47073395 | ||
| Heterogeneity of mitochondrial redox state in premalignant pancreas in a PTEN null transgenic mouse model | Q47134472 | ||
| Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. | Q50517982 | ||
| Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice. | Q50641030 | ||
| Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis. | Q51061806 | ||
| Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. | Q51851366 | ||
| Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. | Q51894736 | ||
| p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis. | Q53021022 | ||
| SOX9 regulates ERBB signalling in pancreatic cancer development. | Q53229089 | ||
| Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice | Q53379866 | ||
| Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. | Q53582791 | ||
| Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. | Q54394742 | ||
| Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. | Q54526478 | ||
| Hypothetical Progression Model of Pancreatic Cancer With Origin in the Centroacinar-Acinar Compartment | Q57767711 | ||
| Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice | Q61776577 | ||
| Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas | Q67533972 | ||
| Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast | Q67660860 | ||
| Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma | Q77214122 | ||
| Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice | Q77494291 | ||
| Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates | Q80378426 | ||
| Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents | Q82181907 | ||
| Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma | Q82193149 | ||
| Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice. | Q41854156 | ||
| Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma | Q41856856 | ||
| DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer | Q41906889 | ||
| Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. | Q41979160 | ||
| Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms | Q41982039 | ||
| Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation | Q42091306 | ||
| Early requirement of Rac1 in a mouse model of pancreatic cancer. | Q42490195 | ||
| Pancreatic carcinoma with multilineage (acinar, neuroendocrine, and ductal) differentiation. | Q42553726 | ||
| Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence | Q42573716 | ||
| Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells | Q42729081 | ||
| Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia | Q42937848 | ||
| Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer | Q45339155 | ||
| ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours. | Q46563062 | ||
| KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin | Q33408107 | ||
| Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer | Q33552870 | ||
| MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice | Q33680759 | ||
| Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia | Q33754775 | ||
| Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1 | Q33783645 | ||
| Fibroblast heterogeneity in the cancer wound | Q33964324 | ||
| Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells | Q33987709 | ||
| PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia | Q34101017 | ||
| PTEN loss accelerates KrasG12D-induced pancreatic cancer development | Q34134396 | ||
| Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma | Q34246014 | ||
| Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions | Q34517052 | ||
| Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma | Q34533078 | ||
| Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α | Q34590266 | ||
| PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice | Q34616196 | ||
| Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions | Q34943207 | ||
| Pancreatic cancer biology and genetics | Q35013204 | ||
| Pdx1 expression in pancreatic precursor lesions and neoplasms | Q35068809 | ||
| Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells | Q35130100 | ||
| Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression | Q35152549 | ||
| A "catastrophic hypothesis" for pancreas cancer progression | Q35154553 | ||
| Dicer regulates differentiation and viability during mouse pancreatic cancer initiation | Q35161464 | ||
| Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia | Q35376826 | ||
| Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia | Q35432049 | ||
| Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice | Q35578568 | ||
| Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo | Q35670102 | ||
| The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential. | Q35732360 | ||
| Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions | Q35887807 | ||
| The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma | Q35954277 | ||
| PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors | Q36245945 | ||
| Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway | Q36288566 | ||
| BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. | Q36319886 | ||
| NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation | Q36367008 | ||
| Pdx1 regulates pancreas tubulogenesis and E-cadherin expression | Q36497262 | ||
| Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression | Q36546501 | ||
| Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma | Q36582547 | ||
| EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma | Q36696146 | ||
| Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells | Q36879043 | ||
| p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas | Q36904676 | ||
| Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia | Q36980230 | ||
| Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice | Q36999854 | ||
| Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. | Q37016288 | ||
| Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs. | Q37071752 | ||
| TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells | Q37147887 | ||
| The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice | Q37241357 | ||
| Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer. | Q37327260 | ||
| Regulation of pancreas plasticity and malignant transformation by Akt signaling. | Q37337834 | ||
| Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. | Q37420478 | ||
| Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia | Q37501557 | ||
| Oncogenic K-Ras requires activation for enhanced activity | Q37582004 | ||
| SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms | Q37621990 | ||
| Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer | Q37628925 | ||
| Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development? | Q37897800 | ||
| International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas | Q38017783 | ||
| The role of PTF1-P48 in pancreatic acinar gene expression | Q38296859 | ||
| Pancreatic Intraepithelial Neoplasia | Q38720267 | ||
| KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis | Q38786245 | ||
| Pancreatic cancer biology and genetics from an evolutionary perspective | Q38904824 | ||
| NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. | Q38916311 | ||
| The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice | Q38919135 | ||
| Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice | Q38965650 | ||
| Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression | Q39051424 | ||
| Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation | Q39156056 | ||
| Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. | Q39337159 | ||
| Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy | Q39372879 | ||
| STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. | Q39540918 | ||
| Ras activity levels control the development of pancreatic diseases. | Q39841946 | ||
| Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis | Q40003054 | ||
| PTF1alpha/p48 transcription factor couples proliferation and differentiation in the exocrine pancreas [corrected]. | Q40516519 | ||
| YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling | Q40989829 | ||
| Hedgehog signaling is required for effective regeneration of exocrine pancreas | Q41761890 | ||
| Identification and manipulation of biliary metaplasia in pancreatic tumors. | Q41770555 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | adenocarcinoma | Q356033 |
| P304 | page(s) | 296-304 | |
| P577 | publication date | 2017-03-08 | |
| P1433 | published in | Nature Reviews Gastroenterology & Hepatology | Q2108255 |
| P1476 | title | Acinar cell plasticity and development of pancreatic ductal adenocarcinoma | |
| P478 | volume | 14 |
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