EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

scientific article published on September 2012

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CCR.2012.08.001
P932PMC publication ID3601542
P698PubMed publication ID22975375
P5875ResearchGate publication ID230848784

P50authorMaria SibiliaQ41133496
Alberto J SchuhmacherQ42574187
Carmen GuerraQ42574190
P2093author name stringMariano Barbacid
Carolina Navas
Isabel Hernández-Porras
P2860cites workCore signaling pathways in human pancreatic cancers revealed by global genomic analysesQ24606006
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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinomaQ29616287
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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.Q34681112
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Q34786695
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinomaQ35825974
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancerQ36550798
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The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinomaQ38447221
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STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Q39540918
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinomaQ39885220
EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinomaQ40282973
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular contextQ40637553
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasiaQ41816001
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescenceQ42573716
Tumour biology: senescence in premalignant tumoursQ42802962
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinomaQ44255802
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.Q53329413
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Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceQ61776577
Ductal metaplasia of human exocrine pancreas and its association with carcinomaQ70078799
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediatesQ80378426
P433issue3
P921main subjectadenocarcinomaQ356033
P304page(s)318-330
P577publication date2012-09-01
P1433published inCancer CellQ280018
P1476titleEGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma
P478volume22

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