| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Peter Storz | |
| Nisha Durand | |||
| P2860 | cites work | DNA Damage, Aging, and Cancer | Q22121931 |
| Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway | Q24337864 | ||
| Managing Pancreatic Adenocarcinoma: A Special Focus in MicroRNA Gene Therapy | Q26749037 | ||
| Systemic Chemotherapy in Advanced Pancreatic Cancer | Q26750440 | ||
| Kirsten Ras* oncogene: Significance of its discovery in human cancer research | Q26751212 | ||
| KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment | Q26751520 | ||
| Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results | Q26774897 | ||
| Immunotherapy for pancreatic ductal adenocarcinoma: an overview of clinical trials | Q26781538 | ||
| Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences | Q26786129 | ||
| Cancer statistics, 2015 | Q27860576 | ||
| Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism | Q28203976 | ||
| d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells | Q28240459 | ||
| Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis | Q28242612 | ||
| The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism | Q28392347 | ||
| Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition | Q28477031 | ||
| Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy | Q28483560 | ||
| EGF receptor is required for KRAS-induced pancreatic tumorigenesis | Q28584901 | ||
| Pancreatic cancer | Q29616288 | ||
| Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity | Q29616651 | ||
| Inflammation meets cancer, with NF-κB as the matchmaker | Q29620242 | ||
| Novel signaling axis for ROS generation during K-Ras-induced cellular transformation | Q30009446 | ||
| Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells | Q30490795 | ||
| Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. | Q30498776 | ||
| Regulation of pancreatic cancer growth by superoxide | Q30516010 | ||
| Study on free radicals and pancreatic fibrosis--pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor | Q31804716 | ||
| KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin | Q33408107 | ||
| Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells | Q33527780 | ||
| Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation | Q33580123 | ||
| MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice | Q33680759 | ||
| Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. | Q33750086 | ||
| Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis | Q33910221 | ||
| Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors | Q34042949 | ||
| Oncogenic KRAS signalling in pancreatic cancer | Q34113460 | ||
| Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer | Q34137350 | ||
| {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment | Q34268186 | ||
| Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells | Q34322148 | ||
| Dietary antioxidants and the aetiology of pancreatic cancer: a cohort study using data from food diaries and biomarkers | Q34349240 | ||
| EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction | Q34383795 | ||
| Antioxidants accelerate lung cancer progression in mice | Q34400895 | ||
| Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts | Q34418354 | ||
| KRas, ROS and the initiation of pancreatic cancer | Q37673906 | ||
| Mitochondrial dismissal in mammals, from protein degradation to mitophagy | Q38166079 | ||
| Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task | Q38193605 | ||
| Resveratrol supplementation: Where are we now and where should we go? | Q38334249 | ||
| Pancreatic cancer: from state-of-the-art treatments to promising novel therapies | Q38396634 | ||
| Plant derived and dietary phenolic antioxidants: anticancer properties. | Q38416096 | ||
| Effective screening for early diagnosis of pancreatic cancer | Q38664230 | ||
| Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities. | Q38688079 | ||
| Pancreatic cancer: Current research and future directions. | Q38705681 | ||
| Cellular and molecular aspects of pancreatic cancer | Q38730160 | ||
| Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives | Q38733520 | ||
| Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation | Q38794797 | ||
| Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition | Q38799932 | ||
| Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4. | Q38847891 | ||
| Superoxide anion radical (O2(-)) degrades methylmercury to inorganic mercury in human astrocytoma cell line (CCF-STTG1). | Q38860082 | ||
| Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation. | Q38926773 | ||
| c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells. | Q38949421 | ||
| A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells. | Q38953565 | ||
| p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway | Q38955021 | ||
| Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation | Q38975626 | ||
| MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance | Q39037653 | ||
| Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer. | Q39044826 | ||
| Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells | Q39079470 | ||
| Reactive oxygen species induce cell death via Akt signaling in rat osteoblast-like cell line ROS 17/2.8. | Q39136997 | ||
| Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance | Q39156707 | ||
| Molecular analysis of the inhibitory effect of N-acetyl-L-cysteine on the proliferation and invasiveness of pancreatic cancer cells | Q39178368 | ||
| Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States | Q39190004 | ||
| BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK. | Q39338962 | ||
| Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells | Q39358965 | ||
| TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2. | Q39610123 | ||
| Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. | Q39677752 | ||
| Mitochondrial dysfunction contributes to oncogene-induced senescence. | Q39837656 | ||
| Ras activity levels control the development of pancreatic diseases. | Q39841946 | ||
| EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2. | Q39900101 | ||
| Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells | Q39939949 | ||
| Modulation of reactive oxygen species in pancreatic cancer. | Q40032903 | ||
| NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases | Q40056077 | ||
| NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells | Q40061927 | ||
| Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | Q40122559 | ||
| Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. | Q40144497 | ||
| The role of superoxide anions in the development of distant tumour recurrence | Q40211347 | ||
| Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells | Q40291371 | ||
| Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. | Q40305878 | ||
| Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase | Q40394667 | ||
| Controlling tumor growth by modulating endogenous production of reactive oxygen species. | Q40459632 | ||
| Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma. | Q40494151 | ||
| Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. | Q40538175 | ||
| Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells | Q40576228 | ||
| Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis | Q41460315 | ||
| Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression | Q41522811 | ||
| Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival | Q41576862 | ||
| Desmoplasia in pancreatic cancer. Can we fight it? | Q41597479 | ||
| ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence | Q41821426 | ||
| Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer | Q41841905 | ||
| NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer | Q42330675 | ||
| N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway | Q42544690 | ||
| Resveratrol induces apoptosis in pancreatic cancer cells. | Q42730841 | ||
| The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. | Q42828834 | ||
| DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer | Q43806308 | ||
| Influence of antioxidative vitamins A, C and E on lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters | Q43812000 | ||
| A phase II study evaluating the tolerability and efficacy of CAELYX (liposomal doxorubicin, Doxil) in the treatment of unresectable pancreatic carcinoma | Q43837271 | ||
| Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells | Q44200538 | ||
| Oxidative stress plays a role in high glucose-induced activation of pancreatic stellate cells | Q44430625 | ||
| Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. | Q44958771 | ||
| N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts | Q45064151 | ||
| Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas | Q45406912 | ||
| Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. | Q46575651 | ||
| A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination. | Q50553669 | ||
| DNA adducts in human pancreatic tissues and their potential role in carcinogenesis. | Q50914822 | ||
| SOX9 regulates ERBB signalling in pancreatic cancer development. | Q53229089 | ||
| A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation. | Q54126501 | ||
| Pancreatic Adenocarcinoma | Q55880513 | ||
| The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial | Q58075433 | ||
| Pancreatic tumors show high levels of hypoxia | Q73173983 | ||
| Externally applied pressure activates pancreatic stellate cells through the generation of intracellular reactive oxygen species | Q80970474 | ||
| Antioxidant status and oxidative stress markers in pancreatic cancer and chronic pancreatitis | Q86543225 | ||
| NF-kappaB: a stress-regulated switch for cell survival. | Q36469293 | ||
| Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia | Q36471334 | ||
| Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines | Q36586351 | ||
| Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities | Q36590413 | ||
| A phase I/II multicentric trial of gemcitabine and epirubicin in patients with advanced pancreatic carcinoma | Q36614272 | ||
| BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells | Q36642909 | ||
| Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. | Q36653078 | ||
| Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. | Q36653423 | ||
| Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. | Q36673245 | ||
| EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma | Q36696146 | ||
| Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis | Q36707119 | ||
| Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol. | Q36740739 | ||
| Pancreatic cancer chemoprevention by phytochemicals | Q36763100 | ||
| Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. | Q36850905 | ||
| Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers | Q37109641 | ||
| Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis | Q37258055 | ||
| Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030. | Q37321160 | ||
| Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine | Q37392942 | ||
| Reactive oxygen species in cancer | Q37431048 | ||
| Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. | Q37542055 | ||
| Oncogenic K-Ras requires activation for enhanced activity | Q37582004 | ||
| LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria | Q34453596 | ||
| Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions | Q34517052 | ||
| RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer | Q34541682 | ||
| Reactive oxygen species in cancer cells: live by the sword, die by the sword. | Q34564435 | ||
| Antioxidant superoxide dismutase - a review: its function, regulation in the testis, and role in male fertility | Q34646635 | ||
| Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN. | Q34661643 | ||
| Risk factors for pancreatic cancer: a summary review of meta-analytical studies | Q34667061 | ||
| Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion | Q34695847 | ||
| Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage | Q34720428 | ||
| Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy | Q34993085 | ||
| Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress | Q35008361 | ||
| Superoxide dismutases-a review of the metal-associated mechanistic variations | Q35012941 | ||
| Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification | Q35038985 | ||
| Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines | Q35062478 | ||
| Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism | Q35064866 | ||
| IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation | Q35140072 | ||
| Analysis of glutathione: implication in redox and detoxification | Q35155844 | ||
| Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. | Q35251686 | ||
| Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia | Q35376826 | ||
| Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach | Q35551914 | ||
| K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis | Q35670198 | ||
| Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells | Q35883238 | ||
| Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness | Q35937785 | ||
| A novel small-molecule YLT256 inhibits proliferation and induces apoptosis both in vitro and in vivo in solid tumors | Q36040929 | ||
| Reactive oxygen species in tumor progression | Q36071787 | ||
| 4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells | Q36076527 | ||
| EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells | Q36078600 | ||
| Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling | Q36107307 | ||
| Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase. | Q36121107 | ||
| A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. | Q36182645 | ||
| Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone | Q36316513 | ||
| Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer | Q36330378 | ||
| Precursors to pancreatic cancer | Q36372625 | ||
| A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia | Q36437690 | ||
| P433 | issue | 1 | |
| P921 | main subject | pancreatic cancer | Q212961 |
| reactive oxygen species | Q424361 | ||
| P304 | page(s) | 19-31 | |
| P577 | publication date | 2016-11-14 | |
| P1433 | published in | Expert Review of Anticancer Therapy | Q2999044 |
| P1476 | title | Targeting reactive oxygen species in development and progression of pancreatic cancer | |
| P478 | volume | 17 |
| Q47384570 | A fast-response fluorescent probe for hypochlorous acid detection and its application in exogenous and endogenous HOCl imaging of living cells. |
| Q48253749 | Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma. |
| Q41082509 | Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2. |
| Q61810548 | Inflammation and pancreatic cancer: An updated review |
| Q91795820 | Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies |
| Q37699563 | Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer |
| Q100758247 | Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage |
| Q46279043 | Selenoproteins and Metastasis |
| Q41662731 | Superoxide Dismutases in Pancreatic Cancer |
| Q49182137 | Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies |
Search more.