scholarly article | Q13442814 |
P50 | author | Clara Lubeseder-Martellato | Q28656550 |
Maria Sibilia | Q41133496 | ||
David W. Threadgill | Q42306006 | ||
Pawel K Mazur | Q42408768 | ||
Barbara M Grüner | Q58212259 | ||
Debjani Pal | Q63952964 | ||
P2093 | author name string | Roland M Schmid | |
Elaine W Raines | |||
M Kay Washington | |||
Carole L Wilson | |||
Peter Storz | |||
Bence Sipos | |||
Howard C Crawford | |||
Christopher J Halbrook | |||
Eileen S Carpenter | |||
Jason C Hall | |||
Kenneth K Takeuchi | |||
Nicole R Murray | |||
Alexander Herner | |||
Jens T Siveke | |||
Nicole Teichmann | |||
Marija Trajkovic-Arsic | |||
Geou-Yarh Liou | |||
Christine M Ardito | |||
Kathleen E Delgiorno | |||
Thomas Briel | |||
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P433 | issue | 3 | |
P921 | main subject | Kirsten rat sarcoma viral oncogene homolog | Q21498354 |
Epidermal growth factor receptor | Q21981692 | ||
P304 | page(s) | 304-317 | |
P577 | publication date | 2012-09-01 | |
P1433 | published in | Cancer Cell | Q280018 |
P1476 | title | EGF receptor is required for KRAS-induced pancreatic tumorigenesis | |
P478 | volume | 22 |
Q36140634 | A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells |
Q36437111 | A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma |
Q37744279 | A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer |
Q37488746 | A modular and flexible ESC-based mouse model of pancreatic cancer. |
Q38902585 | A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy. |
Q59339787 | A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases |
Q44709167 | A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies. |
Q38882024 | A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion |
Q53224745 | A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. |
Q37052477 | ADAM Proteases and Gastrointestinal Function |
Q59137239 | ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy |
Q64067287 | ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer |
Q89721924 | ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1) |
Q92783310 | ADAM17: An Emerging Therapeutic Target for Lung Cancer |
Q27324447 | ADAM8 as a drug target in pancreatic cancer. |
Q61799832 | ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma |
Q47661281 | ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. |
Q91711463 | ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis |
Q36710531 | Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer |
Q38922230 | Acinar cell plasticity and development of pancreatic ductal adenocarcinoma |
Q43491732 | Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice. |
Q35136815 | Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies |
Q96136047 | An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development |
Q37628092 | Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas |
Q54118277 | Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. |
Q36017810 | Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics |
Q36169365 | Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration |
Q47098844 | Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma |
Q33933185 | Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. |
Q89520977 | CA19-9 as a therapeutic target in pancreatitis |
Q39140268 | Canonical wnt signaling is required for pancreatic carcinogenesis |
Q90566625 | Carcinogenesis of Pancreatic Ductal Adenocarcinoma |
Q36801167 | Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer |
Q33816883 | Cholecystokinin and pancreatic cancer: the chicken or the egg? |
Q48212640 | Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition. |
Q35095399 | Coexpression of EGFR and CXCR4 predicts poor prognosis in resected pancreatic ductal adenocarcinoma |
Q92379393 | Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status |
Q37123636 | Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma |
Q35677885 | Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer. |
Q37686308 | Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface |
Q90671653 | Concurrent HER or PI3K Inhibition Potentiates the Antitumor Effect of the ERK Inhibitor Ulixertinib in Preclinical Pancreatic Cancer Models |
Q64256027 | Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma |
Q33910221 | Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis |
Q35158112 | Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy. |
Q91595228 | Differential impact of the ERBB receptors EGFR and ERBB2 on the initiation of precursor lesions of pancreatic ductal adenocarcinoma |
Q38911598 | Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design |
Q34246014 | Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma |
Q33416585 | Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotini |
Q36273532 | Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype |
Q58550279 | EGFR is required for FOS-dependent bone tumor development via RSK2/CREB signaling |
Q92669175 | EGFR, but not COX-2, protein in resected pancreatic ductal adenocarcinoma is associated with poor survival |
Q42109581 | EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression |
Q37704531 | EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth |
Q52357887 | ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis. |
Q41291488 | Elasticity mapping of murine abdominal organs in vivo using harmonic motion imaging (HMI). |
Q24627664 | Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma |
Q64119241 | Encircling the regions of the pharmacogenomic landscape that determine drug response |
Q38844551 | Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells |
Q92068202 | Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles |
Q28084034 | Epidermal growth factor signaling in transformed cells |
Q47121552 | Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice. |
Q38389298 | ErbB-targeted CAR T-cell immunotherapy of cancer |
Q42339289 | FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer |
Q45234060 | GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice |
Q38798496 | GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression |
Q41709484 | Gemcitabine-induced heparanase promotes aggressiveness of pancreatic cancer cells via activating EGFR signaling. |
Q31066570 | Gene expression profile analysis of pancreatic cancer based on microarray data |
Q37343012 | Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. |
Q34657038 | Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine |
Q21129230 | Genetic determinants and potential therapeutic targets for pancreatic adenocarcinoma |
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Q27002973 | Genetically engineered mouse models of pancreatic adenocarcinoma |
Q26765438 | Genetics and biology of pancreatic ductal adenocarcinoma |
Q89520937 | Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy |
Q41966212 | Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. |
Q90814722 | Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation |
Q92917425 | Hiding in plain sight |
Q58726181 | Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance |
Q90465494 | ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer |
Q42056219 | IL27 controls skin tumorigenesis via accumulation of ETAR-positive CD11b cells in the pre-malignant skin |
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Q41856856 | Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma |
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Q55384914 | Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab). |
Q33779491 | Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene |
Q55252335 | In vivo reprogramming drives Kras-induced cancer development. |
Q33727657 | Inflammation to cancer: The molecular biology in the pancreas (Review). |
Q39008845 | Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. |
Q36092073 | Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug. |
Q52723252 | Integrated analysis of tumor differentiation genes in pancreatic adenocarcinoma. |
Q28504893 | Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance |
Q36068611 | K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions |
Q43083283 | KRAS above and beyond - EGFR in pancreatic cancer |
Q33566777 | KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents |
Q37673906 | KRas, ROS and the initiation of pancreatic cancer |
Q34659332 | Kras as a key oncogene and therapeutic target in pancreatic cancer |
Q40291371 | Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells |
Q47754576 | Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells. |
Q36546501 | Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression |
Q34861855 | Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition. |
Q47246517 | Luteolin inhibits pancreatitis‑induced acinar‑ductal metaplasia, proliferation and epithelial‑mesenchymal transition of acinar cells. |
Q33680759 | MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice |
Q51689102 | MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis. |
Q64100823 | MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC) |
Q37071752 | Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs. |
Q34283475 | Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors |
Q36887721 | Mechanisms of resistance to EGFR targeted therapies |
Q26827387 | Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells |
Q99710192 | Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras |
Q41111798 | Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer |
Q37699563 | Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer |
Q37585776 | Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis |
Q26765241 | Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer |
Q33624574 | Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward |
Q38370174 | Molecular Pathogenesis and Targeted Therapy of Pancreatic Cancer |
Q26798453 | Molecular Targeted Intervention for Pancreatic Cancer |
Q46277416 | Molecular genetics and cellular events of K-Ras-driven tumorigenesis. |
Q38211357 | Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: an under-appreciated symbiotic relationship |
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Q26751709 | Molecular therapeutics in pancreas cancer |
Q92134380 | Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis |
Q34943207 | Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions |
Q34517052 | Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions |
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Q37600068 | Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer |
Q38916311 | NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. |
Q36367008 | NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation |
Q42330675 | NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer |
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Q26765238 | Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression |
Q46948614 | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis. |
Q35651453 | New targeted therapies in pancreatic cancer |
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Q34616196 | PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice |
Q38537351 | PLCε signaling in cancer |
Q90371583 | PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response |
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