Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2

scientific article published on 03 September 2013

Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2 is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PNAS..11015389M
P356DOI10.1073/PNAS.1313857110
P932PMC publication ID3780883
P698PubMed publication ID24003140
P5875ResearchGate publication ID256425858

P2093author name stringYosef Yarden
Bilha Schechter
Michael Sela
Ruth Maron
Georg Mahlknecht
Maicol Mancini
P2860cites workPancreatic cancer genomes reveal aberrations in axon guidance pathway genesQ24595981
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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genesQ28307762
Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor functionQ28678683
EGF-ERBB signalling: towards the systems levelQ29619032
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupQ29619344
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activationQ33733313
Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapyQ33837881
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimersQ33888963
Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling.Q34067821
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude miceQ34169387
Herceptin alone or in combination with chemotherapy in the treatment of HER2-positive metastatic breast cancer: pivotal trialsQ34428750
In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruptionQ35836035
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cellsQ36098160
Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR.Q36583011
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinomaQ36696146
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Systems biology of growth factor-induced receptor endocytosisQ37381801
Cancer therapeutic antibodies come of age: targeting minimal residual diseaseQ37453793
A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1-beta binding and co-operates with Herceptin in inhibiting the growth of breast cancer derived cell linesQ39428554
Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy.Q39752760
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor modelsQ39771295
In vivo therapeutic synergism of anti-epidermal growth factor receptor and anti-HER2 monoclonal antibodies against pancreatic carcinomasQ40124759
A comparison of the in vitro and in vivo activities of IgG and F(ab')2 fragments of a mixture of three monoclonal anti-Her-2 antibodiesQ40552147
Targeting multiple Her-2 epitopes with monoclonal antibodies results in improved antigrowth activity of a human breast cancer cell line in vitro and in vivo.Q40725921
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.Q40866492
ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.Q40966152
Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulationQ41710300
Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodiesQ42819445
Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivoQ43683948
Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival.Q54649058
A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptorsQ73359246
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerizationQ84191383
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
pancreatic carcinomaQ18556536
P304page(s)15389-15394
P577publication date2013-09-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2
P478volume110