The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

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The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCB2916
P932PMC publication ID4684081
P698PubMed publication ID24561622
P5875ResearchGate publication ID260374527

P50authorGuido von FiguraQ63133710
Akihisa FukudaQ96232982
P2093author name stringDavid W Dawson
Jorge Ferrer
Matthias Hebrok
Klemens J Hertel
William F Mueller
Matthew A Firpo
Sean J Mulvihill
Holger A Russ
Anke Busch
Grace E Kim
Nilotpal Roy
Muluye E Liku
John P Morris Iv
P2860cites workKras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreasQ24299520
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitorsQ24304941
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaQ24337664
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genesQ24595981
Core signaling pathways in human pancreatic cancers revealed by global genomic analysesQ24606006
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinomaQ24609544
ARID1A mutations in endometriosis-associated ovarian carcinomasQ24610484
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancerQ24633517
TopHat: discovering splice junctions with RNA-SeqQ24655505
The human genome browser at UCSCQ24672361
The Sequence Alignment/Map format and SAMtoolsQ27860966
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancerQ28277002
Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancerQ28277781
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in miceQ28586163
Cells of origin in cancerQ29619557
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Epigenetics and cancer without genomic instability.Q33346513
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse modelQ33818230
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreasQ34100230
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouseQ34596182
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Q34786695
Suppression of lung adenocarcinoma progression by Nkx2-1Q34939788
Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst developmentQ35178284
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancersQ35501591
BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI.Q35545332
Cystic precursors to invasive pancreatic cancerQ35609914
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.Q35619635
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathwaysQ35641254
Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreasQ36221363
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.Q36426956
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restorationQ36570146
SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cellsQ36573136
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locusQ36710858
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult miceQ36999854
Roles of HMGA proteins in cancerQ37001370
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrestQ37165210
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypesQ37249683
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacityQ37262178
Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cystsQ37483711
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladderQ37730596
SWI/SNF nucleosome remodellers and cancer.Q37886668
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiationQ39156056
Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreasQ39469747
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Q39540918
Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunitQ40066403
Role for BRG1 in cell cycle control and tumor suppressionQ40376914
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birthQ43199149
Stabilization of beta-catenin impacts pancreas growth.Q46218922
Evaluation of SOX9 expression in pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasmQ46307212
Targeted knockout of BRG1 potentiates lung cancer developmentQ46593349
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.Q53329413
Expression of METH-1 and METH-2 in pancreatic cancer.Q54501923
Expression of p270(ARID1A), a component of human SWI/SNF complexes, in human tumorsQ58199286
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5Q78570048
HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinomaQ83323078
Intraductal papillary mucinous neoplasmQ84582374
P433issue3
P921main subjectIntraductal papillary mucinous neoplasmQ17149811
adenocarcinomaQ356033
invasive ductal carcinomaQ1671685
mucinous tumorQ6931145
pancreatic ductal carcinomaQ8263002
pancreatic ductal adenocarcinomaQ18555956
P304page(s)255-267
P577publication date2014-02-23
P1433published inNature Cell BiologyQ1574111
P1476titleThe chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
P478volume16

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