The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis

article by Motoyuki Tsuda et al published 1 August 2018 in Journal of Clinical Investigation

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI94287
P932PMC publication ID6063489
P698PubMed publication ID30010625

P50authorHiroshi SenoQ55510294
Seishi OgawaQ56451261
Kyoichi TakaoriQ58446579
Yukiko HiramatsuQ91010180
Takuto YoshiokaQ91249278
Shinji UemotoQ91614513
Nobuyuki KakiuchiQ91813204
Akihisa FukudaQ96232982
Motoyuki TsudaQ104267866
Takahisa MarunoQ104739110
Tsutomu ChibaQ113754504
Haruhiko AkiyamaQ114389882
Norihiro GotoQ116772099
Kozo IkutaQ116772100
Yuichi YamagaQ116772101
Dieter SaurQ116772102
Yoshihide MatsumotoQ116772113
Yoshito KimuraQ116772114
Yutaka TakadaQ116772115
P2093author name stringSatoshi Ogawa
Matthias Hebrok
Grace E Kim
Nilotpal Roy
Christopher V Wright
Kaja Hoyer
Laura Leonhardt
P2860cites workGeneration of transgenic mice for conditional overexpression of Sox9Q24294188
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitorsQ24304941
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisQ28511736
Frequent pathway mutations of splicing machinery in myelodysplasiaQ29616088
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing dataQ30597080
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis.Q54394742
Pancreatic AdenocarcinomaQ55880513
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceQ61776577
Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic miceQ77494291
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediatesQ80378426
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult miceQ87356152
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantationQ33615619
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasiaQ33754775
Organoid models of human and mouse ductal pancreatic cancerQ34456438
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancerQ34729793
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Q34786695
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formationQ35228755
Cystic precursors to invasive pancreatic cancerQ35609914
Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and FunctionQ35881784
Whole genomes redefine the mutational landscape of pancreatic cancerQ35911034
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasiaQ35928158
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinomaQ35954277
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiationQ36058628
Mutant p53: one name, many proteinsQ36070574
Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cellsQ36295189
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinomaQ36384268
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restorationQ36570146
SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cellsQ36573136
Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in miceQ36842602
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasiaQ36980230
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult miceQ36999854
Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expressionQ37452586
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasiaQ37501557
Mechanism of BRG1 silencing in primary cancersQ37636601
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in miceQ38625919
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic CarcinogenesisQ38786245
Genomic analyses identify molecular subtypes of pancreatic cancerQ38791499
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasQ40424687
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasiaQ41816001
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.Q41979160
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Q42269245
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.Q43071629
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.Q43217858
Sox9-dependent acinar-to-ductal reprogramming is critical for pancreatic intraepithelial neoplasia formationQ46179018
Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.Q50891398
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.Q51894736
A multipotent progenitor domain guides pancreatic organogenesis.Q51981704
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3475-3489
P577publication date2018-08-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleThe BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis
P478volume128

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cites work (P2860)
Q919736245-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma
Q92130280A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
Q90139280Ductal vs. acinar? Recent insights into identifying cell lineage of pancreatic ductal adenocarcinoma
Q56530315HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties
Q60046393Inflammation and de-differentiation in pancreatic carcinogenesis
Q99548635Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation
Q98196633The role of histone methylation in the development of digestive cancers: a potential direction for cancer management
Q103805423USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy
Q64245903microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9
Q97534390κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

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