A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

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A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DEV.078634
P932PMC publication ID3383226
P698PubMed publication ID22675211
P5875ResearchGate publication ID225276344

P50authorPhilip SeymourQ42797362
Anne Grapin-BottonQ59509601
P2093author name stringMaike Sander
Claire L Dubois
Hung Ping Shih
Janel L Kopp
Manbir Sandhu
P2860cites workSomatic inactivation of Pkd2 results in polycystic kidney diseaseQ74502174
Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse developmentQ81236437
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreasQ82204856
The mesenchyme controls the timing of pancreatic beta-cell differentiationQ82676076
Neurogenin3 activates the islet differentiation program while repressing its own expressionQ24298415
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitorsQ24304941
Notch signaling controls multiple steps of pancreatic differentiationQ24569636
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreasQ24647944
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
The Wnt signaling pathway in development and diseaseQ27861019
The Notch-Hes pathway in mammalian neural developmentQ28145844
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loopQ28210742
Oscillations in notch signaling regulate maintenance of neural progenitorsQ28275810
Notch signalling controls pancreatic cell differentiationQ28504686
Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in miceQ28505299
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathyQ28506100
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanismQ28508691
The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouseQ28508767
SOX9 is required for maintenance of the pancreatic progenitor cell poolQ28510325
Cardiac defects and renal failure in mice with targeted mutations in Pkd2Q28510555
A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentQ28510710
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formationQ28510770
Control of endodermal endocrine development by Hes-1Q28513574
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identityQ28584929
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreasQ28587560
An LDL-receptor-related protein mediates Wnt signalling in miceQ28588625
SOX9 induces and maintains neural stem cellsQ28591508
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine developmentQ28592848
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6Q28593218
Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial archQ28594436
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesisQ28594731
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitorsQ29619012
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreasQ33287045
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreasQ33665476
Notch gene expression during pancreatic organogenesisQ33904634
Regulation of the pancreatic pro-endocrine gene neurogenin3.Q33945269
Sox9-haploinsufficiency causes glucose intolerance in miceQ33988732
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytesQ34064669
Gene regulatory factors in pancreatic developmentQ34286940
Notch signaling, gamma-secretase inhibitors, and cancer therapyQ34653560
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibitionQ34867170
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.Q35097448
Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas developmentQ35654133
Sox9 coordinates a transcriptional network in pancreatic progenitor cellsQ35973342
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiationQ36710960
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systemsQ37123634
Notch signaling controls the balance of ciliated and secretory cell fates in developing airwaysQ37311674
Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-cateninQ37477745
A transcriptional network in polycystic kidney diseaseQ40775992
Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.Q41602913
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiationQ41929079
Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreasQ41976049
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.Q41979160
Notch signaling controls liver development by regulating biliary differentiationQ42080795
Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development.Q42483413
Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epitheliumQ42559388
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependentQ42724092
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birthQ43199149
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreasQ47073395
Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell typesQ47379825
A multipotent progenitor domain guides pancreatic organogenesis.Q51981704
Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate.Q51998056
A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells.Q52030248
Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells.Q52040958
Conditional inactivation of Sox9: a mouse model for campomelic dysplasia.Q52123522
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.Q55043460
Conditional ablation of Notch signaling in pancreatic developmentQ57847338
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P1104number of pages12
P304page(s)2488-2499
P577publication date2012-06-06
P1433published inDevelopmentQ3025404
P1476titleA Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
P478volume139

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