SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

scientific article published on 10 March 2008

SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.02019-07
P932PMC publication ID2423153
P698PubMed publication ID18332116
P5875ResearchGate publication ID5520372

P2093author name stringC Peter Verrijzer
Marcin M Gorski
Sima Kheradmand Kia
Stavros Giannakopoulos
P2860cites workTranslating the Histone CodeQ22065840
The Polycomb group protein EZH2 directly controls DNA methylationQ24299020
Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancersQ24534231
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsQ24680814
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2Q28181639
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancerQ28277002
Polycomb silencing mechanisms and the management of genomic programmesQ28279277
The epigenomics of cancerQ28289975
Genome regulation by polycomb and trithorax proteinsQ28289984
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumorsQ28294240
Epigenetics: a landscape takes shapeQ29616623
The epigenetic progenitor origin of human cancerQ29617486
Polycomb silencers control cell fate, development and cancerQ29619697
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locusQ29619815
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancerQ29622925
Stabilization of chromatin structure by PRC1, a Polycomb complexQ33868583
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.Q34202062
SWI/SNF chromatin remodeling and cancerQ34493162
On the use of the word 'epigenetic'.Q34615615
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitinationQ34673352
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.Q35565308
The SWI/SNF complex--chromatin and cancer.Q35667471
ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemiaQ35670201
Polycomb response elements and targeting of Polycomb group proteins in Drosophila.Q36567949
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Q36572080
Polycomb/Trithorax response elements and epigenetic memory of cell identityQ36690774
Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.Q38310616
Functional differentiation of SWI/SNF remodelers in transcription and cell cycle controlQ40208956
Oncogenic activity of Cdc6 through repression of the INK4/ARF locusQ40298342
Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.Q40446274
Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymesQ40584373
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cellsQ40618783
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteinsQ41912236
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectorsQ43867083
CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.Q43948180
Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.Q44083876
Polycomb complexes and the propagation of the methylation mark at the Drosophila ubx gene.Q52010804
Senescence comes of ageQ57580244
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)3457-3464
P577publication date2008-03-10
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleSWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
P478volume28

Reverse relations

cites work (P2860)
Q36394208A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro
Q38692678ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers
Q57167864ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response?
Q26849467ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy
Q34627244ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
Q79790429An INKlination for epigenetic control of senescence
Q57306913An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Q50981168Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.
Q36893203Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies
Q34298075BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression
Q36759676BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss
Q36788045BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene.
Q99594988COMPASS and SWI/SNF complexes in development and disease
Q24629853Cellular senescence and tumor suppressor gene p16
Q38261746Chromatin remodeler mutations in human cancers: epigenetic implications
Q37810688Chromatin: a molecular interface between cancer and aging
Q92702721Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes
Q28067573Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression
Q95407636Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
Q42109237DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation
Q42558928DPY30 regulates pathways in cellular senescence through ID protein expression
Q92254227Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Q51116901Deciphering Subunit-Specific Functions within SWI/SNF Complexes.
Q48186642Disruption of mammalian SWI/SNF and Polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities.
Q48262529Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Q96137365Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo
Q50733282Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a.
Q38639828Driver mutations of cancer epigenomes.
Q36835530Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Q41902469Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states
Q34541488EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer
Q59795355EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
Q39433602EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence.
Q55106988Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties.
Q34213023Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
Q34460981Epigenetic control of aging
Q21245250Epigenetic regulation of caloric restriction in aging
Q24604190Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health
Q33604848Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.
Q37841191Epigenetic silencing of tumor suppressor genes in pancreatic cancer
Q90569909Epigenetic synthetic lethality approaches in cancer therapy
Q38709544Epigenomic regulation of oncogenesis by chromatin remodeling
Q34549944Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression
Q36707535Establishment and characterization of MRT cell lines from genetically engineered mouse models and the influence of genetic background on their development.
Q36956610Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.
Q27027021Extracranial rhabdoid tumours: what we have learned so far and future directions
Q38217345Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?
Q30528506Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
Q90243494G-tract RNA removes Polycomb repressive complex 2 from genes
Q36870334Gene silencing and Polycomb group proteins: an overview of their structure, mechanisms and phylogenetics
Q37835825Gene silencing by the Polycomb group proteins and associations with cancer
Q26765438Genetics and biology of pancreatic ductal adenocarcinoma
Q37392280Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.
Q38906678H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer
Q24657459Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
Q35510392Histone methylases as novel drug targets: developing inhibitors of EZH2.
Q100739232Immune responses in genomically simple SWI/SNF-deficient cancers
Q34998257Inactivation of intergenic enhancers by EBNA3A initiates and maintains polycomb signatures across a chromatin domain encoding CXCL10 and CXCL9
Q31111648Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines
Q91259756Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer
Q50284000Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.
Q24632383Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
Q39949572Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.
Q41811052MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells
Q38961785Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Q39229171Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities
Q38747872Marked for death: targeting epigenetic changes in cancer
Q39312199Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Q93039110Modeling medulloblastoma in vivo and with human cerebellar organoids
Q37962015Modulation of gene expression in ovarian cancer by active and repressive histone marks
Q26770685Molecular mechanisms of long noncoding RNAs on gastric cancer
Q42416688Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.
Q92962287NPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors
Q37785984Nucleosome dynamics and epigenetic stability.
Q37122320Nucleosome remodeling and epigenetics.
Q38122565PBRM1 and BAP1 as novel targets for renal cell carcinoma
Q38844565PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311.
Q90261560Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
Q43126163Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Q37629613Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer
Q38283093Polycomb group proteins--epigenetic repressors with emerging roles in melanocytes and melanoma
Q92877957Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function
Q34342958Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.
Q37309123Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
Q42917409Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals
Q33699134Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism
Q37545071Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development
Q38028793Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
Q24337483Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
Q33844721Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets
Q38083797Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer
Q37187733Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
Q38906194Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
Q37924588Roles of the Polycomb group proteins in stem cells and cancer
Q47748373SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters
Q35125250SNF5 reexpression in malignant rhabdoid tumors regulates transcription of target genes by recruitment of SWI/SNF complexes and RNAPII to the transcription start site of their promoters
Q38953852SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.
Q35176127SWI/SNF complexes are required for full activation of the DNA-damage response
Q37886668SWI/SNF nucleosome remodellers and cancer.
Q36163245SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer
Q28269618SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
Q35592205SWItching on the transcriptional circuitry in melanoma
Q38081391Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics
Q35545894Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression
Q24317899Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus
Q33805966Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML.
Q37725658Soft skills turned into hard facts: nucleosome remodelling at developmental switches.
Q38567366Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer
Q28087134Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy
Q35369863TCR-dependent transformation of mature memory phenotype T cells in mice
Q36445523Targeting EZH2 and PRC2 dependence as novel anticancer therapy
Q26769027Targeting EZH2 in cancer
Q35006903The Arabidopsis SWI2/SNF2 chromatin Remodeler BRAHMA regulates polycomb function during vegetative development and directly activates the flowering repressor gene SVP.
Q34170839The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner
Q38896059The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Q39454240The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer
Q88964948The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
Q36384268The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
Q34038585The molecular balancing act of p16(INK4a) in cancer and aging
Q34440758The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.
Q37420245The role of SMARCB1/INI1 in development of rhabdoid tumor.
Q38184514The role of long noncoding RNAs in the epigenetic control of gene expression.
Q37600120The stem cell--chromatin connection.
Q37791830Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins
Q33933332Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras
Q37850681Transcriptional regulation of cellular senescence
Q34235226Trithorax group proteins: switching genes on and keeping them active
Q47823236Two BRM promoter polymorphisms predict poor survival in patients with hepatocellular carcinoma.
Q38856913Upregulated expression of polycomb protein Ring1 contributes to poor prognosis and accelerated proliferation in human hepatocellular carcinoma
Q37122890Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters
Q38247363Vulnerabilities of mutant SWI/SNF complexes in cancer.
Q39325305ZRF1 controls oncogene-induced senescence through the INK4-ARF locus
Q35163529esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
Q35051176βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.

Search more.