The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

scientific article

The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A026930
P932PMC publication ID4968166
P698PubMed publication ID27413115

P50authorCourtney HodgesQ42291159
P2093author name stringGerald R Crabtree
Jacob G Kirkland
P2860cites workThe Spectrum of SWI/SNF Mutations, Ubiquitous in Human CancersQ21090801
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexesQ21134718
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signalingQ22008515
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunitsQ22009033
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomesQ24290517
Selectivity of chromatin-remodelling cofactors for ligand-activated transcriptionQ24292110
The human SWI/SNF subunit Brm is a regulator of alternative splicingQ24298527
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repairQ24302261
Dendrite development regulated by CREST, a calcium-regulated transcriptional activatorQ24304307
Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcomaQ24307456
Identification of a polymorphic, neuron-specific chromatin remodeling complexQ24309294
Purification and biochemical heterogeneity of the mammalian SWI-SNF complexQ24316969
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcriptionQ24319163
A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63Q41312602
Structure of a RSC-nucleosome complex and insights into chromatin remodelingQ41847578
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genomeQ41870312
Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.Q42102894
Mutants of yeast defective in sucrose utilization.Q42117992
Synovial sarcoma is a stem cell malignancy.Q42814246
Genetic and cytological analysis of Drosophila chromatin-remodeling factorsQ46066442
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesisQ46172999
Structural studies of the human PBAF chromatin-remodeling complexQ46323039
The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexesQ46979397
Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wingQ47071483
Large-scale discovery of novel genetic causes of developmental disordersQ47073693
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomasQ48137036
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell functionQ50782942
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversityQ50967175
Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in CancerQ52423960
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.Q52713961
Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factorsQ53276828
Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expressionQ53941920
Recurrent inactivating mutations of ARID2 in non-small cell lung carcinomaQ54288575
Structural analysis of the yeast SWI/SNF chromatin remodeling complex.Q55036306
Activation of the yeast HO gene by release from multiple negative controlsQ68934076
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutationQ24320038
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexesQ24321741
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrestQ24321861
Diversity and specialization of mammalian SWI/SNF complexesQ24322918
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcomaQ24337483
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaQ24337664
Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiaeQ24531149
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding foldQ24556499
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genesQ24595981
SF1 and SF2 helicases: family mattersQ24596016
Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexesQ24602965
A landscape of driver mutations in melanomaQ24603357
Widespread plasticity in CTCF occupancy linked to DNA methylationQ24608987
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinomaQ24609544
ARID1A mutations in endometriosis-associated ovarian carcinomasQ24610484
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastomaQ24630017
Comprehensive molecular characterization of human colon and rectal cancerQ24630415
CHD7 cooperates with PBAF to control multipotent neural crest formationQ24630725
Comprehensive molecular portraits of human breast tumoursQ24630844
MicroRNA-mediated switching of chromatin-remodelling complexes in neural developmentQ24632228
Mediator and cohesin connect gene expression and chromatin architectureQ24632695
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cellsQ24657264
Chromatin topology is coupled to Polycomb group protein subnuclear organizationQ27335771
BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.Q27342280
TreeDyn: towards dynamic graphics and annotations for analyses of treesQ27496507
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBPQ27670717
Structure of an actin-related subcomplex of the SWI/SNF chromatin remodelerQ27676339
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.Q27852975
A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivityQ27929952
A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Q27930598
The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesionQ27930793
Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF.Q27930891
The nuclear actin-related proteins Arp7 and Arp9: a dimeric module that cooperates with architectural proteins for chromatin remodelingQ27930895
A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodelingQ27931157
Architecture of the SWI/SNF-nucleosome complexQ27931306
Involvement of actin-related proteins in ATP-dependent chromatin remodeling.Q27932041
The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activationQ27932341
Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repairQ27932672
DNA polymerase epsilon, acetylases and remodellers cooperate to form a specialized chromatin structure at a tRNA insulator.Q27932706
Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancementQ27933086
Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repairQ27933564
RSC, an essential, abundant chromatin-remodeling complexQ27933821
Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcriptionQ27934409
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaksQ27934796
SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiaeQ27934848
Five SWI genes are required for expression of the HO gene in yeastQ27934975
Subunits of the Yeast SWI/SNF Complex Are Members of the Actin-related Protein (ARP) FamilyQ27935324
The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregationQ27936620
A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeastQ27939865
Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomainsQ27939983
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell linesQ28138156
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneQ28145754
brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2Q28181639
SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stabilityQ28239263
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54Q28243168
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
Comprehensive molecular profiling of lung adenocarcinomaQ28244995
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomesQ28249527
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancerQ28251814
Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndromeQ28262110
Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndromeQ28262120
Topological domains in mammalian genomes identified by analysis of chromatin interactionsQ28264221
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2Q28269618
Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF ComplexesQ28271584
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell linesQ28275084
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencingQ28275103
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancerQ28277002
Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancerQ28277781
Promoter Hypermethylation of ARID1A Gene Is Responsible for Its Low mRNA Expression in Many Invasive Breast CancersQ28284179
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Integrated genomic characterization of endometrial carcinomaQ28289962
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinomaQ28292742
Discovery and saturation analysis of cancer genes across 21 tumour typesQ28305204
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
Regulation of dendritic development by neuron-specific chromatin remodeling complexesQ28511067
Clonal architectures and driver mutations in metastatic melanomasQ28544919
An essential switch in subunit composition of a chromatin remodeling complex during neural developmentQ28585238
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in miceQ28586163
Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathwaysQ28593392
Baf60c is essential for function of BAF chromatin remodelling complexes in heart developmentQ28593688
X-Ray Structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase Core and Its Complex with DNAQ29400687
TimeTree: a public knowledge-base of divergence times among organismsQ29547188
Signatures of mutational processes in human cancerQ29547191
A unique chromatin signature uncovers early developmental enhancers in humansQ29614327
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Role of transposable elements in heterochromatin and epigenetic controlQ29616253
ATP-dependent nucleosome remodelingQ29618979
Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connectionQ29620100
The biology of chromatin remodeling complexesQ29620581
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction methodQ30479086
Barrier proteins remodel and modify chromatin to restrict silenced domainsQ31048023
Epigenetics and cancer without genomic instability.Q33346513
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomasQ33581027
The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPasesQ33606751
Dosage-dependent modifiers of polycomb and antennapedia mutations in DrosophilaQ33663555
Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.Q33725449
Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approachesQ33847769
The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogasterQ33868641
Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutationsQ33952793
Evidence for chromatin-remodeling complex PBAP-controlled maintenance of the Drosophila ovarian germline stem cellsQ33961676
Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complexQ34014577
SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogasterQ34065060
Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signalingQ34131499
The Drosophila BRM complex facilitates global transcription by RNA polymerase IIQ34149658
Structural analysis of the RSC chromatin-remodeling complexQ34159709
MicroRNA-mediated conversion of human fibroblasts to neurons.Q34200249
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformationQ34213023
Transcriptional regulation by trithorax-group proteinsQ34248098
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.Q34342958
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitorsQ34460151
Chemical profiling of the genome with anti-cancer drugs defines target specificitiesQ34475915
3D Chromosome Regulatory Landscape of Human Pluripotent Cells.Q34505845
A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere lengthQ34514337
Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexesQ34563280
Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas.Q34619070
Genomic Classification of Cutaneous MelanomaQ34670776
Chromatin remodelling during developmentQ34698385
Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzymeQ34752076
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signallingQ35020913
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancersQ35092542
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4Q35096087
Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.Q35149596
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb functionQ35163529
Genomic analysis of metastatic cutaneous squamous cell carcinomaQ35178368
Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeastQ35235099
TCR-dependent transformation of mature memory phenotype T cells in miceQ35369863
Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expressionQ35762971
Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomasQ35896475
CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line SetQ36103111
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathwayQ36109039
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancersQ36129157
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencingQ36256943
RSC regulates nucleosome positioning at Pol II genes and density at Pol III genesQ36391981
ATP-dependent chromatin remodeling complexes in Drosophila.Q36527443
The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complexQ36540241
RB and hbrm cooperate to repress the activation functions of E2F1Q36591354
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locusQ36710858
A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteinsQ36710890
RNA helicases--one fold for many functionsQ36851634
BAF complexes facilitate decatenation of DNA by topoisomerase IIαQ36890856
Aberrant promoter hypermethylation ofPBRM1,BAP1,SETD2,KDM6Aand other chromatin-modifying genes is absent or rare in clear cell RCCQ37089505
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotencyQ37125184
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.Q37125189
Mechanisms that specify promoter nucleosome location and identityQ37180651
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memoryQ37184180
Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcomaQ37200438
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complexQ37266000
The role of SMARCB1/INI1 in development of rhabdoid tumor.Q37420245
The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiaeQ37493611
The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1.Q37698349
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladderQ37730596
TFIIIC bound DNA elements in nuclear organization and insulation.Q38045703
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymesQ38126255
INO80-C and SWR-C: guardians of the genomeQ38275882
ARID1B is a specific vulnerability in ARID1A-mutant cancers.Q38276153
Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcriptionQ38289206
Regulation of CSF1 promoter by the SWI/SNF-like BAF complexQ38297752
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.Q38307191
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Q38339385
The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesisQ38485541
SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processingQ38510244
BAF180 promotes cohesion and prevents genome instability and aneuploidyQ38786462
The BAH domain of BAF180 is required for PCNA ubiquitinationQ38859464
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domainsQ38876767
Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatinQ38971238
Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sitesQ39109246
Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma.Q39144774
A role for chromatin remodellers in replication of damaged DNA.Q39341270
Direct imaging of human SWI/SNF-remodeled mono- and polynucleosomes by atomic force microscopy employing carbon nanotube tipsQ39529256
Chromatin-Remodeling Components of the BAF Complex Facilitate ReprogrammingQ39692751
Functional analysis of the DNA-stimulated ATPase domain of yeast SWI2/SNF2.Q39717488
BRIT1/MCPH1 links chromatin remodelling to DNA damage response.Q39838062
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.Q39949572
A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wingQ40016277
Identification of genes required for protection from doxorubicin by a genome-wide screen in Saccharomyces cerevisiaeQ40070246
Functional differentiation of SWI/SNF remodelers in transcription and cell cycle controlQ40208956
The Drosophila brahma complex is an essential coactivator for the trithorax group protein zesteQ40443038
Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.Q40529792
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cellsQ40618783
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genomeQ40708319
Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genesQ40911651
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.Q40924281
P433issue8
P577publication date2016-07-13
P13046publication type of scholarly workreview articleQ7318358
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleThe Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
P478volume6

Reverse relations

cites work (P2860)
Q54255809Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A.
Q52321520Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.
Q92616532BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Q64935151BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer.
Q96952258Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity
Q99594988COMPASS and SWI/SNF complexes in development and disease
Q91840186CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes
Q91900409Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme
Q92476077Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies
Q89578475Chemical and Light Inducible Epigenome Editing
Q58104077Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma
Q91854850Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer
Q47133201Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits
Q61965595Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer
Q57030104DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1
Q29147465De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms
Q89823393Degradation of proteins by PROTACs and other strategies
Q48262529Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Q92492912EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex
Q104802880Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers
Q39448979Epigenetic plasticity and the hallmarks of cancer.
Q99418638Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment
Q91869645Fine-tuning of noise in gene expression with nucleosome remodeling
Q96640402Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL
Q101216847Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients
Q93087881Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells
Q38602104Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.
Q61796311Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
Q60104303Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
Q96610153Genomic profiling in renal cell carcinoma
Q92747204Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts
Q49301622High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.
Q50063994Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide.
Q64084325Inhibition of Triple-Negative Breast Cancer Cell Aggressiveness by Cathepsin D Blockage: Role of Annexin A1
Q92585765Insertional oncogenesis by HPV70 revealed by multiple genomic analyses in a clinically HPV-negative cervical cancer
Q92946067Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for PHF10/BAF45a
Q93039110Modeling medulloblastoma in vivo and with human cerebellar organoids
Q91776801Multi-omic molecular comparison of primary versus metastatic pancreatic tumours
Q58801736Mutational Landscapes and Phenotypic Spectrum of SWI/SNF-Related Intellectual Disability Disorders
Q91622156Mutations in SMARCB1 and in other Coffin-Siris syndrome genes lead to various brain midline defects
Q92854022New Insights into the Role of Polybromo-1 in Prostate Cancer
Q58798742Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
Q48124027Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk.
Q52640415Novel putative drivers revealed by targeted exome sequencing of advanced solid tumors.
Q64980608Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome.
Q51800442Nucleosome remodelling, DNA repair and transcriptional regulation build negative feedback loops in cancer and cellular ageing.
Q41931705PBRM1 restricts the basal activity of innate immune system through repressing RIG-I-like receptor signaling and is a potential prognostic biomarker for colon cancer.
Q36361630Prognostic and Clinicopathological Significance of ARID1A in Endometrium-Related Gynecological Cancers: A Meta-Analysis.
Q91208639R Loops and Their Composite Cancer Connections
Q41701373Rapid and reversible epigenome editing by endogenous chromatin regulators
Q92578345SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines
Q92635006SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility
Q42222276Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin
Q99559613Systematic analysis of bypass suppression of essential genes
Q92710810Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
Q42291151TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin
Q52345656The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
Q92025302The SWI/SNF complex in cancer - biology, biomarkers and therapy
Q91933780The Spatial and Genomic Hierarchy of Tumor Ecosystems Revealed by Single-Cell Technologies
Q38708715The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes
Q47369086The diagnostic role of PTEN and ARID1A in serous effusions.
Q92512795The expanding landscape of 'oncohistone' mutations in human cancers
Q91297749The genetic changes of Wilms tumour
Q57753185The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling
Q90255136The roles of mutated SWI/SNF complexes in the initiation and development of hepatocellular carcinoma and its regulatory effect on the immune system: A review
Q53801893Transcription-associated events affecting genomic integrity.
Q90387732Unwinding chromatin at the right places: how BAF is targeted to specific genomic locations during development
Q57112197Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma
Q53672883Vitamin D Switches BAF Complexes to Protect β Cells.

Search more.